Pharmazeutische/Medizinische Chemie 2

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The following list shows all publications with a direct relation to the organisational unit. To retrieve a list which includes publications of subordinate organisational units, use the search facet "Organizational structure".

• In-Depth Immune-Oncology Studies of the Tumor Microenvironment in a Humanized Melanoma Mouse Model
• Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications
• NanopoReaTA: a user-friendly tool for nanopore-seq real-time transcriptional analysis
• Hydrolysis of tRNA with serum autoantibodies of patients with autoimmune and virus diseases
• Variability of Substrate Specificity of Serum Antibodies Obtained from Patients with Different Autoimmune and Viral Diseases in Reaction of tRNA Hydrolysis.
• Phosphorylation found inside RNA
• Non-Redundant tRNA Reference Sequences for Deep Sequencing Analysis of tRNA Abundance and Epitranscriptomic RNA Modifications
• HITS-CLIP analysis of human ALKBH8 points towards its role in tRNA and noncoding RNA regulation
• Gene Amplification-Associated Overexpression of the Selenoprotein tRNA Enzyme TRIT1 Confers Sensitivity to Arsenic Trioxide in Small-Cell Lung Cancer
• Double methylation of tRNA-U54 to 2′-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7
• High-Throughput Mapping of 2'-O-Me Residues in RNA Using Next-Generation Sequencing (Illumina RiboMethSeq Protocol)
• A Vastly Increased Chemical Variety of RNA Modifications Containing a Thioacetal Structure
• A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA
• Comprehensive DNA methylation analysis of the Aedes aegypti genome
• Sulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast
• High-throughput sequencing for 1-methyladenosine (m1A) mapping in RNA
• Stability of a Split Streptomycin Binding Aptamer
• Urmylation and tRNA thiolation functions of ubiquitin-like Uba4.Urm1 systems are conserved from yeast to man
• Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences
• Related haloarchaeal pleomorphic viruses contain different genome types
• The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu
• Mapping the tRNA Binding Site on the Surface of Human DNMT2 Methyltransferase
• Regulatory RNAs and beyond
• Single-Molecule FRET Reveals a Cooperative Effect of Two Methyl Group Modifications in the Folding of Human Mitochondrial tRNALys
• Measuring Single Small Molecule Binding via Rupture Forces of a Split Aptamer
• Single-Molecule FRET Studies of Counterion Effects on the Free Energy Landscape of Human Mitochondrial Lysine tRNA
• Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET
• In vivo down-regulation of mouse brain capillary P-glycoprotein: A preliminary investigation
• Use of DNAzymes for site-specific analysis of ribonucleotide modifications
• Surveillance of siRNA integrity by FRET imaging
• Molecular dysfunction associated with the human mitochondrial 3302A>G mutation in the MTTL1 (mt-tRNALeu(UUR)) gene
• Optimizing splinted ligation of highly structured small RNAs
• The plant tRNA 3′ processing enzyme has a broad substrate spectrum
• RNase activity of a DNA minor groove binder with a minimalist catalytic motif from RNase A
• Characterization and selectivity of catalytic antibodies from human serum with RNase activity
• FRET Imaging of Cells Transfected with siRNA/Liposome Complexes
• Single-molecule Förster resonance energy transfer studies of RNA structure, dynamics and function
• A Post-Labeling Approach for the Characterization and Quantification of RNA Modifications Based on Site-Directed Cleavage by DNAzymes
• <em>In vitro</em> tRNA Methylation Assay with the <em>Entamoeba histolytica</em> DNA and tRNA Methyltransferase Dnmt2 (Ehmeth) Enzyme
• RNA Intramolecular Dynamics by Single‐Molecule FRET
• Stability of Alkyl Chain-Mediated Lipid Anchoring in Liposomal Membranes
• RNA Modifications Modulate Activation of Innate Toll-Like Receptors
• Identification of an optimized 2′-O-methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8
• Alkyne-Functionalized Coumarin Compound for Analytic and Preparative 4-Thiouridine Labeling
• HITS-CLIP analysis of human ALKBH8 reveals interactions with fully processed substrate tRNAs and with specific noncoding RNAs
• Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B
• Editorial: RNA modifications - what to read first?
• Diastereoselectivity of 5-Methyluridine Osmylation Is Inverted inside an RNA Chain
• The marbled crayfish as a paradigm for saltational speciation by autopolyploidy and parthenogenesis in animals
• Variable presence of 5-methylcytosine in commercial RNA and DNA
• Live cell imaging of duplex siRNA intracellular trafficking
• Recognition of Specified RNA Modifications by the Innate Immune System
• Structure-function relationship of substituted bromomethylcoumarins in nucleoside specificity of RNA alkylation
• Dye selection for live cell imaging of intact siRNA
• Functionalization of Liposomes with Hydrophilic Polymers Results in Macrophage Uptake Independent of the Protein Corona
• 2′-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells
• Effect of a quaternary pentamine on RNA stabilization and enzymatic methylation
• Mg2+-dependent folding of a Diels-Alderase ribozyme probed by single-molecule FRET analysis
• Post-transcriptional nucleotide modification and alternative folding of RNA
• Allosterically activated Diels-Alder catalysis by a ribozyme
• A new mechanism for mtDNA pathogenesis:: impairment of post-transcriptional maturation leads to severe depletion of mitochondrial tRNASer(UCN) caused by T7512C and G7497A point mutations
• A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity
• Nuclear control of cloverleaf structure of human mitochondrial tRNALys
• RNA sex
• Search for characteristic structural features of mammalian mitochondrial tRNAs
• More mistakes by T7 RNA polymerase at the 5′ ends of in vitro-transcribed RNAs
• Search for differences in post-transcriptional modification patterns of mitochondrial DNA-encoded wild-type and mutant human tRNALys and tRNALeu(UUR)
• Sequences outside recognition sets are not neutral for tRNA aminoacylation -: Evidence for nonpermissive combinations of nucleotides in the acceptor stem of yeast tRNAPhe
• A New Nuclear Function of the Entamoeba histolytica Glycolytic Enzyme Enolase: The Metabolic Regulation of Cytosine-5 Methyltransferase 2 (Dnmt2) Activity
• Human DNMT2 methylates tRNAAsp molecules using a DNA methyltransferase-like catalytic mechanism
• A Watson-Crick base-pair-disrupting methyl group (m1A9) is sufficient for cloverleaf folding of human mitochondrial tRNALys
• A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge
• Determination of enrichment factors for modified RNA in MeRIP experiments
• A tRNA half modulates translation as stress response in Trypanosoma brucei
• LC-MS Analysis of Methylated RNA
• Modulation of Mitochondriotropic Properties of Cyanine Dyes by in Organello Copper-Free Click Reaction
• A modified dinucleotide motif specifies tRNA recognition by TLR7
• Preparation of small amounts of sterile siRNA-liposomes with high entrapping efficiency by dual asymmetric centrifugation (DAC)
• Aminoacylation properties of pathology-related human mitochondrial tRNALys variants
• Data Analysis Pipeline for Detection and Quantification of Pseudouridine (ψ) in RNA by HydraPsiSeq
• Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function
• m6A RNA methylation of major satellite repeat transcripts facilitates chromatin association and RNA:DNA hybrid formation in mouse heterochromatin
• Bacterial tRNA 2′-O-methylation is dynamically regulated under stress conditions and modulates innate immune response
• Queuosine-tRNA promotes sex-dependent learning and memory formation by maintaining codon-biased translation elongation speed
• Functional integration of a semi-synthetic azido-queuosine derivative into translation and a tRNA modification circuit
• Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression
• dLimited antibody specificity compromises epitranscriptomic analyses
• Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome
• Methods for RNA Modification Mapping Using Deep Sequencing: Established and New Emerging Technologies
• Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy
• Engineering of a DNA Polymerase for Direct m6A Sequencing
• RNA modifications in physiology and disease: towards clinical applications
• Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines
• Synthesis of point-modified mRNA
• Dihydrouridine in the Transcriptome: New Life for This Ancient RNA Chemical Modification
• An epigenetic 'extreme makeover': the methylation of flaviviral RNA (and beyond)
• Detecting RNA modifications in the epitranscriptome: predict and validate
• The Effect of tRNA[Ser]Sec Isopentenylation on Selenoprotein Expression
• FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA
• Next-Generation Sequencing-Based RiboMethSeq Protocol for Analysis of tRNA 2-O-Methylation
• Analysis of RNA modifications by liquid chromatography-tandem mass spectrometry
• Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine
• New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes
• Pseudouridine: Still mysterious, but never a fake (uridine)!
• Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders
• Posttranscriptional RNA Modifications: Playing Metabolic Games in a Cell's Chemical Legoland
• RNA mediated Toll-like receptor stimulation in health and disease
• Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity
• Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator
• AlkAniline-Seq: Profiling of m7G and m3C RNA Modifications at Single Nucleotide Resolution
• MODOMICS: a database of RNA modification pathways. 2017 update
• Illumina-based RiboMethSeq approach for mapping of 2'-O-Me residues in RNA
• Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation
• The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA
• 5-methylcytosine in RNA: detection, enzymatic formation and biological functions
• A methyl group controls conformational equilibrium in human mitochondrial tRNALys
• Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d
• Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120
• Partial Methylation at Am100 in 18S rRNA of Baker's Yeast Reveals Ribosome Heterogeneity on the Level of Eukaryotic rRNA Modification
• RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
• Cationic Nanohydrogel Particles as Potential siRNA Carriers for Cellular Delivery
• RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
• Expanding the chemical scope of RNA : methyltransferases to site-specific alkynylation of RNA for click labeling
• Detection of RNA modifications
• Hakai is required for stabilization of core components of the m6A mRNA methylation machinery
• MODOMICS: a database of RNA modification pathways-2013 update
• Functional redundancy in tRNA dihydrouridylation
• Positioning Europe for the EPITRANSCRIPTOMICS challenge
• Fluoropyrimidines trigger decay of hypomodified tRNA in yeast
• The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent
• An Optimized Microscale Thermophoresis Method for High- Throughput Screening of DNA Methyltransferase 2 Ligands
• CoverageAnalyzer (CAn): A Tool for Inspection of Modification Signatures in RNA Sequencing Profiles
• N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer’s disease
• General Principles and Limitations for Detection of RNA Modifications by Sequencing
• RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics
• HydraPsiSeq: a method for systematic and quantitative mapping of pseudouridines in RNA
• Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs
• Absolute Quantification of Noncoding RNA by Microscale Thermophoresis
• 2′-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms
• Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs
• Orthogonal Click Conjugation to the Liposomal Surface Reveals the Stability of the Lipid Anchorage as Crucial for Targeting
• m6A modulates neuronal functions and sex determination in Drosophila
• DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position
• Loss of Anticodon Wobble Uridine Modifications Affects tRNALys Function and Protein Levels in Saccharomyces cerevisiae
• Phosphorylation of Elp1 by Hrr25 Is Required for Elongator-Dependent tRNA Modification in Yeast
• The Guanidinium Group as a Key Part of Water-Soluble Polymer Carriers for siRNA Complexation and Protection against Degradation
• RNA nucleotide methylation
• tRNA Stabilization by Modified Nucleotides
• Sculpting an RNA conformational energy landscape by a methyl group modification - A single-molecule FRET study
• Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts.: Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene
• Use of Specific Chemical Reagents for Detection of Modified Nucleotides in RNA
• RNA nucleotide methylation: 2021 update
• General Principles for the Detection of Modified Nucleotides in RNA by Specific Reagents
• Intermolecular ‘cross-torque’ : the N4-cytosine propargyl residue is rotated to the ‘CH’-edge as a result of Watson–Crick interaction
• GADD45a physically and functionally interacts with TET1
• Absolute and relative quantification of RNA modifications via biosynthetic isotopomers

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• Institut für Pharmazeutische und Biomedizinische Wissenschaften