Dihydrouridine in the Transcriptome: New Life for This Ancient RNA Chemical Modification

Publication type:
Journal article
Metadata:
Autoren
  • Damien Bregeon
  • Ludovic Pecqueur
  • Sabrine Toubdji
  • Claudia Sudol
  • Murielle Lombard
  • Marc Fontecave
  • Valerie de Crecy-Lagard
  • Yuri Motorin
  • Mark Helm
  • Djemel Hamdane
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000818691000001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1021/acschembio.2c00307
eISSN
1554-8937
Externe Identifier
  • Clarivate Analytics Document Solution ID: 2N9KX
  • PubMed Identifier: 35737906
ISSN
1554-8929
Zeitschrift
ACS CHEMICAL BIOLOGY
Datum der Veröffentlichung
2022
Status
Published
Titel
Dihydrouridine in the Transcriptome: New Life for This Ancient RNA Chemical Modification
Sub types
  • Article
  • Early Access

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Damien Brégeon
  • Ludovic Pecqueur
  • Sabrine Toubdji
  • Claudia Sudol
  • Murielle Lombard
  • Marc Fontecave
  • Valérie de Crécy-Lagard
  • Yuri Motorin
  • Mark Helm
  • Djemel Hamdane
DOI
10.1021/acschembio.2c00307
eISSN
1554-8937
ISSN
1554-8929
Ausgabe der Veröffentlichung
7
Zeitschrift
ACS Chemical Biology
Sprache
en
Online publication date
2022
Paginierung
1638 - 1657
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
American Chemical Society (ACS)
Herausgeber URL
http://dx.doi.org/10.1021/acschembio.2c00307
Datum der Datenerfassung
2023
Titel
Dihydrouridine in the Transcriptome: New Life for This Ancient RNA Chemical Modification
Ausgabe der Zeitschrift
17

Data source: Crossref

Abstract
Until recently, post-transcriptional modifications of RNA were largely restricted to noncoding RNA species. However, this belief seems to have quickly dissipated with the growing number of new modifications found in mRNA that were originally thought to be primarily tRNA-specific, such as dihydrouridine. Recently, transcriptomic profiling, metabolic labeling, and proteomics have identified unexpected dihydrouridylation of mRNAs, greatly expanding the catalog of novel mRNA modifications. These data also implicated dihydrouridylation in meiotic chromosome segregation, protein translation rates, and cell proliferation. Dihydrouridylation of tRNAs and mRNAs are introduced by flavin-dependent dihydrouridine synthases. In this review, we will briefly outline the current knowledge on the distribution of dihydrouridines in the transcriptome, their chemical labeling, and highlight structural and mechanistic aspects regarding the dihydrouridine synthases enzyme family. A special emphasis on important research directions to be addressed will also be discussed. This new entry of dihydrouridine into mRNA modifications has definitely added a new layer of information that controls protein synthesis.
Addresses
  • IBPS, Biology of Aging and Adaptation, Sorbonne Université, Paris 75252, France.
Autoren
  • Damien Brégeon
  • Ludovic Pecqueur
  • Sabrine Toubdji
  • Claudia Sudol
  • Murielle Lombard
  • Marc Fontecave
  • Valérie de Crécy-Lagard
  • Yuri Motorin
  • Mark Helm
  • Djemel Hamdane
DOI
10.1021/acschembio.2c00307
eISSN
1554-8937
Externe Identifier
  • PubMed Identifier: 35737906
Funding acknowledgements
  • Agence Nationale de la Recherche: 20-CE92-0030
  • National Institute of General Medical Sciences: GM132254
  • Deutsche Forschungsgemeinschaft: HE 3397/13-2
  • Deutsche Forschungsgemeinschaft: HE 3397/21-1
  • Agence Nationale de la Recherche: ANR-11-LABX-0011
  • Deutsche Forschungsgemeinschaft: TRR-319TP A05
  • Deutsche Forschungsgemeinschaft: SPP1784
  • NIGMS NIH HHS: R01 GM132254
Open access
false
ISSN
1554-8929
Ausgabe der Veröffentlichung
7
Zeitschrift
ACS chemical biology
Schlüsselwörter
  • RNA
  • RNA, Messenger
  • RNA, Transfer
  • Protein Biosynthesis
  • RNA Processing, Post-Transcriptional
  • Transcriptome
Sprache
eng
Medium
Print-Electronic
Online publication date
2022
Paginierung
1638 - 1657
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2022
Titel
Dihydrouridine in the Transcriptome: New Life for This Ancient RNA Chemical Modification.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
17

Data source: Europe PubMed Central

Abstract
Until recently, post-transcriptional modifications of RNA were largely restricted to noncoding RNA species. However, this belief seems to have quickly dissipated with the growing number of new modifications found in mRNA that were originally thought to be primarily tRNA-specific, such as dihydrouridine. Recently, transcriptomic profiling, metabolic labeling, and proteomics have identified unexpected dihydrouridylation of mRNAs, greatly expanding the catalog of novel mRNA modifications. These data also implicated dihydrouridylation in meiotic chromosome segregation, protein translation rates, and cell proliferation. Dihydrouridylation of tRNAs and mRNAs are introduced by flavin-dependent dihydrouridine synthases. In this review, we will briefly outline the current knowledge on the distribution of dihydrouridines in the transcriptome, their chemical labeling, and highlight structural and mechanistic aspects regarding the dihydrouridine synthases enzyme family. A special emphasis on important research directions to be addressed will also be discussed. This new entry of dihydrouridine into mRNA modifications has definitely added a new layer of information that controls protein synthesis.
Autoren
  • Damien Brégeon
  • Ludovic Pecqueur
  • Sabrine Toubdji
  • Claudia Sudol
  • Murielle Lombard
  • Marc Fontecave
  • Valérie de Crécy-Lagard
  • Yuri Motorin
  • Mark Helm
  • Djemel Hamdane
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/35737906
DOI
10.1021/acschembio.2c00307
eISSN
1554-8937
Funding acknowledgements
  • NIGMS NIH HHS: R01 GM132254
Ausgabe der Veröffentlichung
7
Zeitschrift
ACS Chem Biol
Schlüsselwörter
  • Protein Biosynthesis
  • RNA
  • RNA Processing, Post-Transcriptional
  • RNA, Messenger
  • RNA, Transfer
  • Transcriptome
Sprache
eng
Country
United States
Paginierung
1638 - 1657
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Dihydrouridine in the Transcriptome: New Life for This Ancient RNA Chemical Modification.
Sub types
  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
17

Data source: PubMed

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