From traditional Chinese medicine to rational cancer therapy
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Thomas Efferth
- Paul CH Li
- Venkata S Badireenath Konkimalla
- Bernd Kaina
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000248999300005&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.molmed.2007.07.001
- eISSN
- 1471-499X
- Externe Identifier
- Clarivate Analytics Document Solution ID: 203UK
- PubMed Identifier: 17644431
- ISSN
- 1471-4914
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- TRENDS IN MOLECULAR MEDICINE
- Paginierung
- 353 - 361
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Titel
- From traditional Chinese medicine to rational cancer therapy
- Sub types
- Review
- Ausgabe der Zeitschrift
- 13
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Thomas Efferth
- Paul CH Li
- Venkata S Badireenath Konkimalla
- Bernd Kaina
- DOI
- 10.1016/j.molmed.2007.07.001
- ISSN
- 1471-4914
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Trends in Molecular Medicine
- Sprache
- en
- Paginierung
- 353 - 361
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.molmed.2007.07.001
- Datum der Datenerfassung
- 2020
- Titel
- From traditional Chinese medicine to rational cancer therapy
- Ausgabe der Zeitschrift
- 13
Datenquelle: Crossref
- Abstract
- Many natural products and derivatives thereof belong to the standard repertoire of cancer chemotherapy. Examples are Vinca alkaloids, taxanes and camptothecins. In recent years, the potential of natural products from plants, notably from medicinal plants used in traditional Chinese medicine (TCM), has been recognized by the scientific community in the Western world. To provide an example of the most recent developments in this field, we have selected several compounds, namely artesunate, homoharringtonine, arsenic trioxide and cantharidin, that are found in natural TCM products and that have the potential for use in cancer therapy. Controlled clinical studies have shown that homoharringtonine and arsenic trioxide can exert profound activity against leukaemia. Increased knowledge of the molecular mechanisms of TCM-derived drugs and recent developments in their applications demonstrate that the combination of TCM with modern cutting-edge technologies provides an attractive strategy for the development of novel and improved cancer therapeutics.
- Addresses
- German Cancer Research Center, Pharmaceutical Biology (C015), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
- Autoren
- Thomas Efferth
- Thomas Efferth
- Paul CH Li
- Venkata S Badireenath Konkimalla
- Bernd Kaina
- DOI
- 10.1016/j.molmed.2007.07.001
- eISSN
- 1471-499X
- Externe Identifier
- PubMed Identifier: 17644431
- Open access
- false
- ISSN
- 1471-4914
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Trends in molecular medicine
- Schlüsselwörter
- Animals
- Humans
- Neoplasms
- Antineoplastic Agents, Phytogenic
- Medicine, Chinese Traditional
- Pharmacognosy
- Western World
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2007
- Paginierung
- 353 - 361
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Datum der Datenerfassung
- 2007
- Titel
- From traditional Chinese medicine to rational cancer therapy.
- Sub types
- Research Support, Non-U.S. Gov't
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 13
Datenquelle: Europe PubMed Central
- Abstract
- Many natural products and derivatives thereof belong to the standard repertoire of cancer chemotherapy. Examples are Vinca alkaloids, taxanes and camptothecins. In recent years, the potential of natural products from plants, notably from medicinal plants used in traditional Chinese medicine (TCM), has been recognized by the scientific community in the Western world. To provide an example of the most recent developments in this field, we have selected several compounds, namely artesunate, homoharringtonine, arsenic trioxide and cantharidin, that are found in natural TCM products and that have the potential for use in cancer therapy. Controlled clinical studies have shown that homoharringtonine and arsenic trioxide can exert profound activity against leukaemia. Increased knowledge of the molecular mechanisms of TCM-derived drugs and recent developments in their applications demonstrate that the combination of TCM with modern cutting-edge technologies provides an attractive strategy for the development of novel and improved cancer therapeutics.
- Date of acceptance
- 2007
- Autoren
- Thomas Efferth
- Paul CH Li
- Venkata S Badireenath Konkimalla
- Bernd Kaina
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/17644431
- DOI
- 10.1016/j.molmed.2007.07.001
- ISSN
- 1471-4914
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Trends Mol Med
- Schlüsselwörter
- Animals
- Antineoplastic Agents, Phytogenic
- Humans
- Medicine, Chinese Traditional
- Neoplasms
- Pharmacognosy
- Western World
- Sprache
- eng
- Country
- England
- Paginierung
- 353 - 361
- PII
- S1471-4914(07)00128-1
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2007
- Titel
- From traditional Chinese medicine to rational cancer therapy.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
- Ausgabe der Zeitschrift
- 13
Datenquelle: PubMed
- Beziehungen:
- Eigentum von