From traditional Chinese medicine to rational cancer therapy

Publication type:
Journal article
Metadata:
Autoren
  • Thomas Efferth
  • Paul CH Li
  • Venkata S Badireenath Konkimalla
  • Bernd Kaina
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000248999300005&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.molmed.2007.07.001
eISSN
1471-499X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 203UK
  • PubMed Identifier: 17644431
ISSN
1471-4914
Ausgabe der Veröffentlichung
8
Zeitschrift
TRENDS IN MOLECULAR MEDICINE
Paginierung
353 - 361
Datum der Veröffentlichung
2007
Status
Published
Titel
From traditional Chinese medicine to rational cancer therapy
Sub types
  • Review
Ausgabe der Zeitschrift
13

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Thomas Efferth
  • Paul CH Li
  • Venkata S Badireenath Konkimalla
  • Bernd Kaina
DOI
10.1016/j.molmed.2007.07.001
ISSN
1471-4914
Ausgabe der Veröffentlichung
8
Zeitschrift
Trends in Molecular Medicine
Sprache
en
Paginierung
353 - 361
Datum der Veröffentlichung
2007
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.molmed.2007.07.001
Datum der Datenerfassung
2020
Titel
From traditional Chinese medicine to rational cancer therapy
Ausgabe der Zeitschrift
13

Data source: Crossref

Abstract
Many natural products and derivatives thereof belong to the standard repertoire of cancer chemotherapy. Examples are Vinca alkaloids, taxanes and camptothecins. In recent years, the potential of natural products from plants, notably from medicinal plants used in traditional Chinese medicine (TCM), has been recognized by the scientific community in the Western world. To provide an example of the most recent developments in this field, we have selected several compounds, namely artesunate, homoharringtonine, arsenic trioxide and cantharidin, that are found in natural TCM products and that have the potential for use in cancer therapy. Controlled clinical studies have shown that homoharringtonine and arsenic trioxide can exert profound activity against leukaemia. Increased knowledge of the molecular mechanisms of TCM-derived drugs and recent developments in their applications demonstrate that the combination of TCM with modern cutting-edge technologies provides an attractive strategy for the development of novel and improved cancer therapeutics.
Addresses
  • German Cancer Research Center, Pharmaceutical Biology (C015), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Autoren
  • Thomas Efferth
  • Thomas Efferth
  • Paul CH Li
  • Venkata S Badireenath Konkimalla
  • Bernd Kaina
DOI
10.1016/j.molmed.2007.07.001
eISSN
1471-499X
Externe Identifier
  • PubMed Identifier: 17644431
Open access
false
ISSN
1471-4914
Ausgabe der Veröffentlichung
8
Zeitschrift
Trends in molecular medicine
Schlüsselwörter
  • Animals
  • Humans
  • Neoplasms
  • Antineoplastic Agents, Phytogenic
  • Medicine, Chinese Traditional
  • Pharmacognosy
  • Western World
Sprache
eng
Medium
Print-Electronic
Online publication date
2007
Paginierung
353 - 361
Datum der Veröffentlichung
2007
Status
Published
Datum der Datenerfassung
2007
Titel
From traditional Chinese medicine to rational cancer therapy.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
13

Data source: Europe PubMed Central

Abstract
Many natural products and derivatives thereof belong to the standard repertoire of cancer chemotherapy. Examples are Vinca alkaloids, taxanes and camptothecins. In recent years, the potential of natural products from plants, notably from medicinal plants used in traditional Chinese medicine (TCM), has been recognized by the scientific community in the Western world. To provide an example of the most recent developments in this field, we have selected several compounds, namely artesunate, homoharringtonine, arsenic trioxide and cantharidin, that are found in natural TCM products and that have the potential for use in cancer therapy. Controlled clinical studies have shown that homoharringtonine and arsenic trioxide can exert profound activity against leukaemia. Increased knowledge of the molecular mechanisms of TCM-derived drugs and recent developments in their applications demonstrate that the combination of TCM with modern cutting-edge technologies provides an attractive strategy for the development of novel and improved cancer therapeutics.
Date of acceptance
2007
Autoren
  • Thomas Efferth
  • Paul CH Li
  • Venkata S Badireenath Konkimalla
  • Bernd Kaina
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/17644431
DOI
10.1016/j.molmed.2007.07.001
ISSN
1471-4914
Ausgabe der Veröffentlichung
8
Zeitschrift
Trends Mol Med
Schlüsselwörter
  • Animals
  • Antineoplastic Agents, Phytogenic
  • Humans
  • Medicine, Chinese Traditional
  • Neoplasms
  • Pharmacognosy
  • Western World
Sprache
eng
Country
England
Paginierung
353 - 361
PII
S1471-4914(07)00128-1
Datum der Veröffentlichung
2007
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2007
Titel
From traditional Chinese medicine to rational cancer therapy.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
13

Data source: PubMed

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