Mechanisms of Herb-Induced Nephrotoxicity
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- T Allard
- T Wenner
- HJ Greten
- T Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000320158700006&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.2174/0929867311320220006
- eISSN
- 1875-533X
- Externe Identifier
- Clarivate Analytics Document Solution ID: 160ZH
- PubMed Identifier: 23597204
- ISSN
- 0929-8673
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- CURRENT MEDICINAL CHEMISTRY
- Schlüsselwörter
- Analgesic nephropathy
- apoptosis
- blood pressure
- DNA adducts
- mitochondrial ATP synthesis
- nephrolithiasis
- phytotherapy
- pharmacognosy
- Paginierung
- 2812 - 2819
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Titel
- Mechanisms of Herb-Induced Nephrotoxicity
- Sub types
- Article
- Ausgabe der Zeitschrift
- 20
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- T Allard
- T Wenner
- H Greten
- T Efferth
- DOI
- 10.2174/0929867311320220006
- ISSN
- 0929-8673
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- Current Medicinal Chemistry
- Sprache
- en
- Paginierung
- 2812 - 2819
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Herausgeber
- Bentham Science Publishers Ltd.
- Herausgeber URL
- http://dx.doi.org/10.2174/0929867311320220006
- Datum der Datenerfassung
- 2015
- Titel
- Mechanisms of Herb-Induced Nephrotoxicity
- Ausgabe der Zeitschrift
- 20
Datenquelle: Crossref
- Abstract
- Herbal therapies gained much popularity among the general public, but compared to therapies approved by official authorities, toxicological studies are frequently not available for them. Hence, there may be inherent risks and the kidneys may be especially vulnerable to toxic effects. Herbs may induce nephrotoxicity by induction of apoptosis. High oxalate contents in Star fruit (Averrhoa carambola L.) may induce acute nephropathy. Triptolide from Thunder God Vine (Triperygium wilfordii Hook) is a diterpenoid epoxide with induces reactive oxygen species and nephrotubular apoptosis. Cranberry juice is discussed as promoter of kidney stone formation (nephrolithiasis). Abuse of guaifenesin from Roughbark (Guaicum officinale L.) increases stone formation. Aristolochia acids from Aristolochia fangchi Y.C.Wu ex L.D. Chow & S.M. Hwang causes the well-known aristolochic acid nephropathy and carcinogenesis by DNA adduct formation. Carboxyatractyloside from Impila (Callilepsis laureola DC.) inhibits mitochondrial ATP synthesis. Acute allergic interstitial nephritis was diagnosed after intake of Peruvian Cat's claw (Uncaria tomentosa Willd. DC.). Whether or not Willow Bark (Salix alba L.) induces analgesic nephropathwy is a matter of discussion. Other herbal therapies are considered to affect the rennin-angiotensisn-aldosterone (RAA) system Ephedra sinica Stapf with its ingredient ephedrine. Devil's Claw (Harpagophytum procumbens DC. Ex Meisn.) and licorice (Glycyrrhiza glabra L.) may inhibit major renal transport processes needed for filtration, secretion, and absorption. Strategies to minimize nephrotoxicity include (1) quality control and standardization of herbal products, (2) research on the molecular modes of action to better understand pathophysiological mechanisms of herbal products as well as (3) clinical trials to demonstrate efficacy and safety.
- Addresses
- Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
- Autoren
- T Allard
- T Wenner
- HJ Greten
- T Efferth
- T Efferth
- DOI
- 10.2174/0929867311320220006
- eISSN
- 1875-533X
- Externe Identifier
- PubMed Identifier: 23597204
- Open access
- false
- ISSN
- 0929-8673
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- Current medicinal chemistry
- Schlüsselwörter
- Animals
- Humans
- Plants, Medicinal
- Kidney Diseases
- Arachidonic Acid
- DNA Adducts
- Adenosine Triphosphate
- Apoptosis
- Blood Pressure
- Sprache
- eng
- Medium
- Paginierung
- 2812 - 2819
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Datum der Datenerfassung
- 2013
- Titel
- Mechanisms of herb-induced nephrotoxicity.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 20
Datenquelle: Europe PubMed Central
- Abstract
- Herbal therapies gained much popularity among the general public, but compared to therapies approved by official authorities, toxicological studies are frequently not available for them. Hence, there may be inherent risks and the kidneys may be especially vulnerable to toxic effects. Herbs may induce nephrotoxicity by induction of apoptosis. High oxalate contents in Star fruit (Averrhoa carambola L.) may induce acute nephropathy. Triptolide from Thunder God Vine (Triperygium wilfordii Hook) is a diterpenoid epoxide with induces reactive oxygen species and nephrotubular apoptosis. Cranberry juice is discussed as promoter of kidney stone formation (nephrolithiasis). Abuse of guaifenesin from Roughbark (Guaicum officinale L.) increases stone formation. Aristolochia acids from Aristolochia fangchi Y.C.Wu ex L.D. Chow & S.M. Hwang causes the well-known aristolochic acid nephropathy and carcinogenesis by DNA adduct formation. Carboxyatractyloside from Impila (Callilepsis laureola DC.) inhibits mitochondrial ATP synthesis. Acute allergic interstitial nephritis was diagnosed after intake of Peruvian Cat's claw (Uncaria tomentosa Willd. DC.). Whether or not Willow Bark (Salix alba L.) induces analgesic nephropathwy is a matter of discussion. Other herbal therapies are considered to affect the rennin-angiotensisn-aldosterone (RAA) system Ephedra sinica Stapf with its ingredient ephedrine. Devil's Claw (Harpagophytum procumbens DC. Ex Meisn.) and licorice (Glycyrrhiza glabra L.) may inhibit major renal transport processes needed for filtration, secretion, and absorption. Strategies to minimize nephrotoxicity include (1) quality control and standardization of herbal products, (2) research on the molecular modes of action to better understand pathophysiological mechanisms of herbal products as well as (3) clinical trials to demonstrate efficacy and safety.
- Date of acceptance
- 2013
- Autoren
- T Allard
- T Wenner
- HJ Greten
- T Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/23597204
- DOI
- 10.2174/0929867311320220006
- eISSN
- 1875-533X
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- Curr Med Chem
- Schlüsselwörter
- Adenosine Triphosphate
- Animals
- Apoptosis
- Arachidonic Acid
- Blood Pressure
- DNA Adducts
- Humans
- Kidney Diseases
- Plants, Medicinal
- Sprache
- eng
- Country
- United Arab Emirates
- Paginierung
- 2812 - 2819
- PII
- CMC-EPUB-20130412-4
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2014
- Titel
- Mechanisms of herb-induced nephrotoxicity.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 20
Datenquelle: PubMed
- Beziehungen:
- Eigentum von