Mechanisms of Herb-Induced Nephrotoxicity

Autoren

T Allard
T Wenner
H Greten
T Efferth

DOI

10.2174/0929867311320220006

ISSN

0929-8673

Ausgabe der Veröffentlichung

22

Zeitschrift

Current Medicinal Chemistry

Sprache

en

Paginierung

2812 - 2819

Datum der Veröffentlichung

2013

Status

Published

Herausgeber

Bentham Science Publishers Ltd.

Herausgeber URL

http://dx.doi.org/10.2174/0929867311320220006

Datum der Datenerfassung

2015

Titel

Mechanisms of Herb-Induced Nephrotoxicity

Ausgabe der Zeitschrift

20

Data source: Crossref

Abstract

Herbal therapies gained much popularity among the general public, but compared to therapies approved by official authorities, toxicological studies are frequently not available for them. Hence, there may be inherent risks and the kidneys may be especially vulnerable to toxic effects. Herbs may induce nephrotoxicity by induction of apoptosis. High oxalate contents in Star fruit (Averrhoa carambola L.) may induce acute nephropathy. Triptolide from Thunder God Vine (Triperygium wilfordii Hook) is a diterpenoid epoxide with induces reactive oxygen species and nephrotubular apoptosis. Cranberry juice is discussed as promoter of kidney stone formation (nephrolithiasis). Abuse of guaifenesin from Roughbark (Guaicum officinale L.) increases stone formation. Aristolochia acids from Aristolochia fangchi Y.C.Wu ex L.D. Chow & S.M. Hwang causes the well-known aristolochic acid nephropathy and carcinogenesis by DNA adduct formation. Carboxyatractyloside from Impila (Callilepsis laureola DC.) inhibits mitochondrial ATP synthesis. Acute allergic interstitial nephritis was diagnosed after intake of Peruvian Cat's claw (Uncaria tomentosa Willd. DC.). Whether or not Willow Bark (Salix alba L.) induces analgesic nephropathwy is a matter of discussion. Other herbal therapies are considered to affect the rennin-angiotensisn-aldosterone (RAA) system Ephedra sinica Stapf with its ingredient ephedrine. Devil's Claw (Harpagophytum procumbens DC. Ex Meisn.) and licorice (Glycyrrhiza glabra L.) may inhibit major renal transport processes needed for filtration, secretion, and absorption. Strategies to minimize nephrotoxicity include (1) quality control and standardization of herbal products, (2) research on the molecular modes of action to better understand pathophysiological mechanisms of herbal products as well as (3) clinical trials to demonstrate efficacy and safety.

Addresses

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.

Autoren

T Allard
T Wenner
HJ Greten
T Efferth
T Efferth

DOI

10.2174/0929867311320220006

eISSN

1875-533X

Externe Identifier

PubMed Identifier: 23597204

Open access

false

ISSN

0929-8673

Ausgabe der Veröffentlichung

22

Zeitschrift

Current medicinal chemistry

Schlüsselwörter

Animals
Humans
Plants, Medicinal
Kidney Diseases
Arachidonic Acid
DNA Adducts
Adenosine Triphosphate
Apoptosis
Blood Pressure

Sprache

eng

Medium

Print

Paginierung

2812 - 2819

Datum der Veröffentlichung

2013

Status

Published

Datum der Datenerfassung

2013

Titel

Mechanisms of herb-induced nephrotoxicity.

Sub types

Review
Journal Article

Ausgabe der Zeitschrift

20

Data source: Europe PubMed Central

Abstract

Herbal therapies gained much popularity among the general public, but compared to therapies approved by official authorities, toxicological studies are frequently not available for them. Hence, there may be inherent risks and the kidneys may be especially vulnerable to toxic effects. Herbs may induce nephrotoxicity by induction of apoptosis. High oxalate contents in Star fruit (Averrhoa carambola L.) may induce acute nephropathy. Triptolide from Thunder God Vine (Triperygium wilfordii Hook) is a diterpenoid epoxide with induces reactive oxygen species and nephrotubular apoptosis. Cranberry juice is discussed as promoter of kidney stone formation (nephrolithiasis). Abuse of guaifenesin from Roughbark (Guaicum officinale L.) increases stone formation. Aristolochia acids from Aristolochia fangchi Y.C.Wu ex L.D. Chow & S.M. Hwang causes the well-known aristolochic acid nephropathy and carcinogenesis by DNA adduct formation. Carboxyatractyloside from Impila (Callilepsis laureola DC.) inhibits mitochondrial ATP synthesis. Acute allergic interstitial nephritis was diagnosed after intake of Peruvian Cat's claw (Uncaria tomentosa Willd. DC.). Whether or not Willow Bark (Salix alba L.) induces analgesic nephropathwy is a matter of discussion. Other herbal therapies are considered to affect the rennin-angiotensisn-aldosterone (RAA) system Ephedra sinica Stapf with its ingredient ephedrine. Devil's Claw (Harpagophytum procumbens DC. Ex Meisn.) and licorice (Glycyrrhiza glabra L.) may inhibit major renal transport processes needed for filtration, secretion, and absorption. Strategies to minimize nephrotoxicity include (1) quality control and standardization of herbal products, (2) research on the molecular modes of action to better understand pathophysiological mechanisms of herbal products as well as (3) clinical trials to demonstrate efficacy and safety.

Date of acceptance

2013

Autoren

T Allard
T Wenner
HJ Greten
T Efferth

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/23597204

DOI

10.2174/0929867311320220006

eISSN

1875-533X

Ausgabe der Veröffentlichung

22

Zeitschrift

Curr Med Chem

Schlüsselwörter

Adenosine Triphosphate
Animals
Apoptosis
Arachidonic Acid
Blood Pressure
DNA Adducts
Humans
Kidney Diseases
Plants, Medicinal

Sprache

eng

Country

United Arab Emirates

Paginierung

2812 - 2819

PII

CMC-EPUB-20130412-4

Datum der Veröffentlichung

2013

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2014

Titel

Mechanisms of herb-induced nephrotoxicity.

Sub types

Journal Article
Review

Ausgabe der Zeitschrift

20

Data source: PubMed

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