Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Paramasivan Poornima
- Jothi Dinesh Kumar
- Qiaoli Zhao
- Martina Blunder
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000384784000029&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.phrs.2016.06.018
- Externe Identifier
- Clarivate Analytics Document Solution ID: DY0JV
- PubMed Identifier: 27329331
- ISSN
- 1043-6618
- Zeitschrift
- PHARMACOLOGICAL RESEARCH
- Schlüsselwörter
- Eleutherococcus senticosus
- Genomics
- Green tea polyphenolics
- Lithospermum erythrorhizon
- Metabolomics
- Polypharmacology
- Proteomics
- Rhodiola rosea
- Schisandra chinensis
- Synthetic lethality
- Systems biology
- Transcriptomics
- Paginierung
- 290 - 302
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature
- Sub types
- Review
- Ausgabe der Zeitschrift
- 111
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Paramasivan Poornima
- Jothi Dinesh Kumar
- Qiaoli Zhao
- Martina Blunder
- Thomas Efferth
- DOI
- 10.1016/j.phrs.2016.06.018
- ISSN
- 1043-6618
- Zeitschrift
- Pharmacological Research
- Sprache
- en
- Paginierung
- 290 - 302
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.phrs.2016.06.018
- Datum der Datenerfassung
- 2023
- Titel
- Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature
- Ausgabe der Zeitschrift
- 111
Datenquelle: Crossref
- Abstract
- Despite massive investments in drug research and development, the significant decline in the number of new drugs approved or translated to clinical use raises the question, whether single targeted drug discovery is the right approach. To combat complex systemic diseases that harbour robust biological networks such as cancer, single target intervention is proved to be ineffective. In such cases, network pharmacology approaches are highly useful, because they differ from conventional drug discovery by addressing the ability of drugs to target numerous proteins or networks involved in a disease. Pleiotropic natural products are one of the promising strategies due to their multi-targeting and due to lower side effects. In this review, we discuss the application of network pharmacology for cancer drug discovery. We provide an overview of the current state of knowledge on network pharmacology, focus on different technical approaches and implications for cancer therapy (e.g. polypharmacology and synthetic lethality), and illustrate the therapeutic potential with selected examples green tea polyphenolics, Eleutherococcus senticosus, Rhodiola rosea, and Schisandra chinensis). Finally, we present future perspectives on their plausible applications for diagnosis and therapy of cancer.
- Addresses
- School of Chemistry, Bangor University, Bangor, Gwynedd LL57 2DG, United Kingdom.
- Autoren
- Paramasivan Poornima
- Jothi Dinesh Kumar
- Qiaoli Zhao
- Martina Blunder
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1016/j.phrs.2016.06.018
- eISSN
- 1096-1186
- Externe Identifier
- PubMed Identifier: 27329331
- Open access
- false
- ISSN
- 1043-6618
- Zeitschrift
- Pharmacological research
- Schlüsselwörter
- Animals
- Humans
- Plants, Medicinal
- Neoplasms
- Antineoplastic Agents, Phytogenic
- Phytotherapy
- Gene Expression Profiling
- Proteomics
- Systems Biology
- Signal Transduction
- Gene Expression Regulation, Neoplastic
- Gene Regulatory Networks
- Metabolomics
- Drug Discovery
- Epigenomics
- Molecular Targeted Therapy
- Protein Interaction Maps
- Biomarkers, Tumor
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2016
- Paginierung
- 290 - 302
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum der Datenerfassung
- 2016
- Titel
- Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 111
Datenquelle: Europe PubMed Central
- Abstract
- Despite massive investments in drug research and development, the significant decline in the number of new drugs approved or translated to clinical use raises the question, whether single targeted drug discovery is the right approach. To combat complex systemic diseases that harbour robust biological networks such as cancer, single target intervention is proved to be ineffective. In such cases, network pharmacology approaches are highly useful, because they differ from conventional drug discovery by addressing the ability of drugs to target numerous proteins or networks involved in a disease. Pleiotropic natural products are one of the promising strategies due to their multi-targeting and due to lower side effects. In this review, we discuss the application of network pharmacology for cancer drug discovery. We provide an overview of the current state of knowledge on network pharmacology, focus on different technical approaches and implications for cancer therapy (e.g. polypharmacology and synthetic lethality), and illustrate the therapeutic potential with selected examples green tea polyphenolics, Eleutherococcus senticosus, Rhodiola rosea, and Schisandra chinensis). Finally, we present future perspectives on their plausible applications for diagnosis and therapy of cancer.
- Date of acceptance
- 2016
- Autoren
- Paramasivan Poornima
- Jothi Dinesh Kumar
- Qiaoli Zhao
- Martina Blunder
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/27329331
- DOI
- 10.1016/j.phrs.2016.06.018
- eISSN
- 1096-1186
- Zeitschrift
- Pharmacol Res
- Schlüsselwörter
- Eleutherococcus senticosus
- Genomics
- Green tea polyphenolics
- Lithospermum erythrorhizon
- Metabolomics
- Polypharmacology
- Proteomics
- Rhodiola rosea
- Schisandra chinensis
- Synthetic lethality
- Systems biology
- Transcriptomics
- Animals
- Antineoplastic Agents, Phytogenic
- Biomarkers, Tumor
- Drug Discovery
- Epigenomics
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Gene Regulatory Networks
- Humans
- Metabolomics
- Molecular Targeted Therapy
- Neoplasms
- Phytotherapy
- Plants, Medicinal
- Protein Interaction Maps
- Proteomics
- Signal Transduction
- Systems Biology
- Sprache
- eng
- Country
- Netherlands
- Paginierung
- 290 - 302
- PII
- S1043-6618(15)30187-0
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2018
- Titel
- Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 111
Datenquelle: PubMed
- Beziehungen:
- Eigentum von