Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature

Autoren

Paramasivan Poornima
Jothi Dinesh Kumar
Qiaoli Zhao
Martina Blunder
Thomas Efferth

DOI

10.1016/j.phrs.2016.06.018

ISSN

1043-6618

Zeitschrift

Pharmacological Research

Sprache

en

Paginierung

290 - 302

Datum der Veröffentlichung

2016

Status

Published

Herausgeber

Elsevier BV

Herausgeber URL

http://dx.doi.org/10.1016/j.phrs.2016.06.018

Datum der Datenerfassung

2023

Titel

Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature

Ausgabe der Zeitschrift

111

Data source: Crossref

Abstract

Despite massive investments in drug research and development, the significant decline in the number of new drugs approved or translated to clinical use raises the question, whether single targeted drug discovery is the right approach. To combat complex systemic diseases that harbour robust biological networks such as cancer, single target intervention is proved to be ineffective. In such cases, network pharmacology approaches are highly useful, because they differ from conventional drug discovery by addressing the ability of drugs to target numerous proteins or networks involved in a disease. Pleiotropic natural products are one of the promising strategies due to their multi-targeting and due to lower side effects. In this review, we discuss the application of network pharmacology for cancer drug discovery. We provide an overview of the current state of knowledge on network pharmacology, focus on different technical approaches and implications for cancer therapy (e.g. polypharmacology and synthetic lethality), and illustrate the therapeutic potential with selected examples green tea polyphenolics, Eleutherococcus senticosus, Rhodiola rosea, and Schisandra chinensis). Finally, we present future perspectives on their plausible applications for diagnosis and therapy of cancer.

Addresses

School of Chemistry, Bangor University, Bangor, Gwynedd LL57 2DG, United Kingdom.

Autoren

Paramasivan Poornima
Jothi Dinesh Kumar
Qiaoli Zhao
Martina Blunder
Thomas Efferth
Thomas Efferth

DOI

10.1016/j.phrs.2016.06.018

eISSN

1096-1186

Externe Identifier

PubMed Identifier: 27329331

Open access

false

ISSN

1043-6618

Zeitschrift

Pharmacological research

Schlüsselwörter

Animals
Humans
Plants, Medicinal
Neoplasms
Antineoplastic Agents, Phytogenic
Phytotherapy
Gene Expression Profiling
Proteomics
Systems Biology
Signal Transduction
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Metabolomics
Drug Discovery
Epigenomics
Molecular Targeted Therapy
Protein Interaction Maps
Biomarkers, Tumor

Sprache

eng

Medium

Print-Electronic

Online publication date

2016

Paginierung

290 - 302

Datum der Veröffentlichung

2016

Status

Published

Datum der Datenerfassung

2016

Titel

Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature.

Sub types

Review
Journal Article

Ausgabe der Zeitschrift

111

Data source: Europe PubMed Central

Abstract

Despite massive investments in drug research and development, the significant decline in the number of new drugs approved or translated to clinical use raises the question, whether single targeted drug discovery is the right approach. To combat complex systemic diseases that harbour robust biological networks such as cancer, single target intervention is proved to be ineffective. In such cases, network pharmacology approaches are highly useful, because they differ from conventional drug discovery by addressing the ability of drugs to target numerous proteins or networks involved in a disease. Pleiotropic natural products are one of the promising strategies due to their multi-targeting and due to lower side effects. In this review, we discuss the application of network pharmacology for cancer drug discovery. We provide an overview of the current state of knowledge on network pharmacology, focus on different technical approaches and implications for cancer therapy (e.g. polypharmacology and synthetic lethality), and illustrate the therapeutic potential with selected examples green tea polyphenolics, Eleutherococcus senticosus, Rhodiola rosea, and Schisandra chinensis). Finally, we present future perspectives on their plausible applications for diagnosis and therapy of cancer.

Date of acceptance

2016

Autoren

Paramasivan Poornima
Jothi Dinesh Kumar
Qiaoli Zhao
Martina Blunder
Thomas Efferth

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/27329331

DOI

10.1016/j.phrs.2016.06.018

eISSN

1096-1186

Zeitschrift

Pharmacol Res

Schlüsselwörter

Eleutherococcus senticosus
Genomics
Green tea polyphenolics
Lithospermum erythrorhizon
Metabolomics
Polypharmacology
Proteomics
Rhodiola rosea
Schisandra chinensis
Synthetic lethality
Systems biology
Transcriptomics
Animals
Antineoplastic Agents, Phytogenic
Biomarkers, Tumor
Drug Discovery
Epigenomics
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Humans
Metabolomics
Molecular Targeted Therapy
Neoplasms
Phytotherapy
Plants, Medicinal
Protein Interaction Maps
Proteomics
Signal Transduction
Systems Biology

Sprache

eng

Country

Netherlands

Paginierung

290 - 302

PII

S1043-6618(15)30187-0

Datum der Veröffentlichung

2016

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2018

Titel

Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature.

Sub types

Journal Article
Review

Ausgabe der Zeitschrift

111

Data source: PubMed

Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature

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