How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- M Schmidt
- A Giessl
- T Laufs
- T Hankeln
- U Wolfrum
- T Burmester
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000180462200076&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1074/jbc.M209909200
- eISSN
- 1083-351X
- Externe Identifier
- Clarivate Analytics Document Solution ID: 636NK
- PubMed Identifier: 12409290
- ISSN
- 0021-9258
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- JOURNAL OF BIOLOGICAL CHEMISTRY
- Paginierung
- 1932 - 1935
- Datum der Veröffentlichung
- 2003
- Status
- Published
- Titel
- How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina
- Sub types
- Article
- Ausgabe der Zeitschrift
- 278
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Marc Schmidt
- Andreas Giessl
- Tilmann Laufs
- Thomas Hankeln
- Uwe Wolfrum
- Thorsten Burmester
- DOI
- 10.1074/jbc.m209909200
- ISSN
- 0021-9258
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Journal of Biological Chemistry
- Sprache
- en
- Paginierung
- 1932 - 1935
- Datum der Veröffentlichung
- 2003
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1074/jbc.m209909200
- Datum der Datenerfassung
- 2021
- Titel
- How Does the Eye Breathe?
- Ausgabe der Zeitschrift
- 278
Data source: Crossref
- Abstract
- Visual performance of the vertebrate eye requires large amounts of oxygen, and thus the retina is one of the highest oxygen-consuming tissues of the body. Here we show that neuroglobin, a neuron-specific respiratory protein distantly related to hemoglobin and myoglobin, is present at high amounts in the mouse retina (approximately 100 microm). The estimated concentration of neuroglobin in the retina is thus about 100-fold higher than in the brain and is in the same range as that of myoglobin in the muscle. Neuroglobin is expressed in all neurons of the retina but not in the retinal pigment epithelium. Neuroglobin mRNA was detected in the perikarya of the nuclear and ganglion layers of the neuronal retina, whereas the protein was present mainly in the plexiform layers and in the ellipsoid region of photoreceptor inner segment. The distribution of neuroglobin correlates with the subcellular localization of mitochondria and with the relative oxygen demands, as the plexiform layers and the inner segment consume most of the retinal oxygen. These findings suggest that neuroglobin supplies oxygen to the retina, similar to myoglobin in the myocardium and the skeletal muscle.
- Addresses
- Department of Molecular Animal Physiology , Institute of Zoology, Johannes Gutenberg University of Mainz, D-55099 Mainz, Germany.
- Autoren
- Marc Schmidt
- Andreas Giessl
- Tilmann Laufs
- Thomas Hankeln
- Uwe Wolfrum
- Thorsten Burmester
- DOI
- 10.1074/jbc.m209909200
- eISSN
- 1083-351X
- Externe Identifier
- PubMed Identifier: 12409290
- Open access
- false
- ISSN
- 0021-9258
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- The Journal of biological chemistry
- Schlüsselwörter
- Retina
- Animals
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice
- Oxygen
- Globins
- Nerve Tissue Proteins
- Photoreceptor Cells, Vertebrate
- Neuroglobin
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2002
- Paginierung
- 1932 - 1935
- Datum der Veröffentlichung
- 2003
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2002
- Titel
- How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 278
Data source: Europe PubMed Central
- Abstract
- Visual performance of the vertebrate eye requires large amounts of oxygen, and thus the retina is one of the highest oxygen-consuming tissues of the body. Here we show that neuroglobin, a neuron-specific respiratory protein distantly related to hemoglobin and myoglobin, is present at high amounts in the mouse retina (approximately 100 microm). The estimated concentration of neuroglobin in the retina is thus about 100-fold higher than in the brain and is in the same range as that of myoglobin in the muscle. Neuroglobin is expressed in all neurons of the retina but not in the retinal pigment epithelium. Neuroglobin mRNA was detected in the perikarya of the nuclear and ganglion layers of the neuronal retina, whereas the protein was present mainly in the plexiform layers and in the ellipsoid region of photoreceptor inner segment. The distribution of neuroglobin correlates with the subcellular localization of mitochondria and with the relative oxygen demands, as the plexiform layers and the inner segment consume most of the retinal oxygen. These findings suggest that neuroglobin supplies oxygen to the retina, similar to myoglobin in the myocardium and the skeletal muscle.
- Autoren
- Marc Schmidt
- Andreas Giessl
- Tilmann Laufs
- Thomas Hankeln
- Uwe Wolfrum
- Thorsten Burmester
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/12409290
- DOI
- 10.1074/jbc.M209909200
- ISSN
- 0021-9258
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- J Biol Chem
- Schlüsselwörter
- Animals
- Globins
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Nerve Tissue Proteins
- Neuroglobin
- Oxygen
- Photoreceptor Cells, Vertebrate
- Retina
- Sprache
- eng
- Country
- United States
- Paginierung
- 1932 - 1935
- PII
- S0021-9258(19)31121-4
- Datum der Veröffentlichung
- 2003
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2003
- Titel
- How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 278
Data source: PubMed
- Beziehungen:
- Property of