Centrins in retinal photoreceptor cells:: Regulators in the connecting cilium
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Philipp Trojan
- Norbert Krauss
- Hui-Woog Choe
- Andreas Giessl
- Alexander Pulvermueller
- Uwe Wolfrum
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000256926300001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.preteyeres.2008.01.003
- Externe Identifier
- Clarivate Analytics Document Solution ID: 316CK
- PubMed Identifier: 18329314
- ISSN
- 1350-9462
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- PROGRESS IN RETINAL AND EYE RESEARCH
- Schlüsselwörter
- Ca(2+)-binding proteins
- centrins
- retina
- photoreceptor cells
- transducin
- light-dependent translocation
- Paginierung
- 237 - 259
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Titel
- Centrins in retinal photoreceptor cells:: Regulators in the connecting cilium
- Sub types
- Review
- Ausgabe der Zeitschrift
- 27
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Philipp Trojan
- Norbert Krauss
- Hui-Woog Choe
- Andreas Gießl
- Alexander Pulvermüller
- Uwe Wolfrum
- DOI
- 10.1016/j.preteyeres.2008.01.003
- ISSN
- 1350-9462
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Progress in Retinal and Eye Research
- Sprache
- en
- Paginierung
- 237 - 259
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.preteyeres.2008.01.003
- Datum der Datenerfassung
- 2021
- Titel
- Centrins in retinal photoreceptor cells: Regulators in the connecting cilium
- Ausgabe der Zeitschrift
- 27
Data source: Crossref
- Abstract
- Changes in the intracellular Ca2+ concentration regulate the visual signal transduction cascade directly or more often indirectly through Ca2+-binding proteins. Here we focus on centrins, which are members of a highly conserved subgroup of the EF-hand superfamily of Ca2+-binding proteins in photoreceptor cells of the vertebrate retina. Centrins are commonly associated with centrosome-related structures. In mammalian retinal photoreceptor cells, four centrin isoforms are expressed as prominent components in the connecting cilium linking the light-sensitive outer segment compartment with the metabolically active inner segment compartment. Our data indicate that Ca2+-activated centrin isoforms assemble into protein complexes with the visual heterotrimeric G-protein transducin. This interaction of centrins with transducin is mediated by binding to the betagamma-dimer of the heterotrimeric G-protein. More recent findings show that these interactions of centrins with transducin are reciprocally regulated via site-specific phosphorylations mediated by the protein kinase CK2. The assembly of centrin/G-protein complexes is a novel aspect of translocation regulation of signalling proteins in sensory cells, and represents a potential link between molecular trafficking and signal transduction in general.
- Addresses
- Institut für Zoologie, Johannes Gutenberg-Universität Mainz, 55099 Mainz, Germany.
- Autoren
- Philipp Trojan
- Norbert Krauss
- Hui-Woog Choe
- Andreas Giessl
- Alexander Pulvermüller
- Uwe Wolfrum
- DOI
- 10.1016/j.preteyeres.2008.01.003
- eISSN
- 1873-1635
- Externe Identifier
- PubMed Identifier: 18329314
- Open access
- false
- ISSN
- 1350-9462
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Progress in retinal and eye research
- Schlüsselwörter
- Cilia
- Animals
- Humans
- Calcium
- Calcium-Binding Proteins
- Contractile Proteins
- Eye Proteins
- Chromosomal Proteins, Non-Histone
- Vision, Ocular
- Photoreceptor Cells, Vertebrate
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2008
- Paginierung
- 237 - 259
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Datum der Datenerfassung
- 2008
- Titel
- Centrins in retinal photoreceptor cells: regulators in the connecting cilium.
- Sub types
- Research Support, Non-U.S. Gov't
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 27
Data source: Europe PubMed Central
- Abstract
- Changes in the intracellular Ca2+ concentration regulate the visual signal transduction cascade directly or more often indirectly through Ca2+-binding proteins. Here we focus on centrins, which are members of a highly conserved subgroup of the EF-hand superfamily of Ca2+-binding proteins in photoreceptor cells of the vertebrate retina. Centrins are commonly associated with centrosome-related structures. In mammalian retinal photoreceptor cells, four centrin isoforms are expressed as prominent components in the connecting cilium linking the light-sensitive outer segment compartment with the metabolically active inner segment compartment. Our data indicate that Ca2+-activated centrin isoforms assemble into protein complexes with the visual heterotrimeric G-protein transducin. This interaction of centrins with transducin is mediated by binding to the betagamma-dimer of the heterotrimeric G-protein. More recent findings show that these interactions of centrins with transducin are reciprocally regulated via site-specific phosphorylations mediated by the protein kinase CK2. The assembly of centrin/G-protein complexes is a novel aspect of translocation regulation of signalling proteins in sensory cells, and represents a potential link between molecular trafficking and signal transduction in general.
- Autoren
- Philipp Trojan
- Norbert Krauss
- Hui-Woog Choe
- Andreas Giessl
- Alexander Pulvermüller
- Uwe Wolfrum
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/18329314
- DOI
- 10.1016/j.preteyeres.2008.01.003
- ISSN
- 1350-9462
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Prog Retin Eye Res
- Schlüsselwörter
- Animals
- Calcium
- Calcium-Binding Proteins
- Chromosomal Proteins, Non-Histone
- Cilia
- Contractile Proteins
- Eye Proteins
- Humans
- Photoreceptor Cells, Vertebrate
- Vision, Ocular
- Sprache
- eng
- Country
- England
- Paginierung
- 237 - 259
- PII
- S1350-9462(08)00011-6
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2008
- Titel
- Centrins in retinal photoreceptor cells: regulators in the connecting cilium.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
- Ausgabe der Zeitschrift
- 27
Data source: PubMed
- Beziehungen:
- Property of