Active zone proteins are dynamically associated with synaptic ribbons in rat pinealocytes

Publication type:
Journal article
Metadata:
Autoren
  • Isabella Spiwoks-Becker
  • Christian Maus
  • Susanne tom Dieck
  • Anna Fejtova
  • Lydia Engel
  • Tanja Wolloscheck
  • Uwe Wolfrum
  • Lutz Vollrath
  • Rainer Spessert
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000257918200002&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1007/s00441-008-0627-3
eISSN
1432-0878
Externe Identifier
  • Clarivate Analytics Document Solution ID: 330CX
  • PubMed Identifier: 18523806
ISSN
0302-766X
Ausgabe der Veröffentlichung
2
Zeitschrift
CELL AND TISSUE RESEARCH
Schlüsselwörter
  • cytomatrix at the active zone
  • RIBEYE
  • ribbon synapse
  • circadian system
  • rat (Sprague Dawley)
Paginierung
185 - 195
Datum der Veröffentlichung
2008
Status
Published
Titel
Active zone proteins are dynamically associated with synaptic ribbons in rat pinealocytes
Sub types
  • Article
Ausgabe der Zeitschrift
333

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Isabella Spiwoks-Becker
  • Christian Maus
  • Susanne tom Dieck
  • Anna Fejtová
  • Lydia Engel
  • Tanja Wolloscheck
  • Uwe Wolfrum
  • Lutz Vollrath
  • Rainer Spessert
DOI
10.1007/s00441-008-0627-3
eISSN
1432-0878
ISSN
0302-766X
Ausgabe der Veröffentlichung
2
Zeitschrift
Cell and Tissue Research
Sprache
en
Artikelnummer
185
Online publication date
2008
Datum der Veröffentlichung
2008
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/s00441-008-0627-3
Datum der Datenerfassung
2021
Titel
Active zone proteins are dynamically associated with synaptic ribbons in rat pinealocytes
Ausgabe der Zeitschrift
333

Data source: Crossref

Abstract
Synaptic ribbons (SRs) are prominent organelles that are abundant in the ribbon synapses of sensory neurons where they represent a specialization of the cytomatrix at the active zone (CAZ). SRs occur not only in neurons, but also in neuroendocrine pinealocytes where their function is still obscure. In this study, we report that pinealocyte SRs are associated with CAZ proteins such as Bassoon, Piccolo, CtBP1, Munc13-1, and the motorprotein KIF3A and, therefore, consist of a protein complex that resembles the ribbon complex of retinal and other sensory ribbon synapses. The pinealocyte ribbon complex is biochemically dynamic. Its protein composition changes in favor of Bassoon, Piccolo, and Munc13-1 at night and in favor of KIF3A during the day, whereas CtBP1 is equally present during the night and day. The diurnal dynamics of the ribbon complex persist under constant darkness and decrease after stimulus deprivation of the pineal gland by constant light. Our findings indicate that neuroendocrine pinealocytes possess a protein complex that resembles the CAZ of ribbon synapses in sensory organs and whose dynamics are under circadian regulation.
Addresses
  • Department of Anatomy and Cell Biology, Johannes Gutenberg University, Becherweg 13, Mainz, Germany. spiwoks@uni-mainz.de
Autoren
  • Isabella Spiwoks-Becker
  • Christian Maus
  • Susanne tom Dieck
  • Anna Fejtová
  • Lydia Engel
  • Tanja Wolloscheck
  • Uwe Wolfrum
  • Lutz Vollrath
  • Rainer Spessert
DOI
10.1007/s00441-008-0627-3
eISSN
1432-0878
Externe Identifier
  • PubMed Identifier: 18523806
  • PubMed Central ID: PMC2757586
Open access
true
ISSN
0302-766X
Ausgabe der Veröffentlichung
2
Zeitschrift
Cell and tissue research
Schlüsselwörter
  • Pineal Gland
  • Synapses
  • Synaptic Membranes
  • Animals
  • Rats
  • Rats, Sprague-Dawley
  • Neuropeptides
  • Cytoskeletal Proteins
  • Eye Proteins
  • Nerve Tissue Proteins
  • Synaptic Transmission
  • Circadian Rhythm
  • Light
  • Darkness
  • Female
  • Male
  • Photoreceptor Cells, Vertebrate
  • Kinesins
Sprache
eng
Medium
Print-Electronic
Online publication date
2008
Open access status
Open Access
Paginierung
185 - 195
Datum der Veröffentlichung
2008
Status
Published
Publisher licence
CC BY-NC
Datum der Datenerfassung
2008
Titel
Active zone proteins are dynamically associated with synaptic ribbons in rat pinealocytes.
Sub types
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
333

Files

https://link.springer.com/content/pdf/10.1007/s00441-008-0627-3.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18523806/pdf/?tool=EBI https://europepmc.org/articles/PMC2757586?pdf=render

Data source: Europe PubMed Central

Abstract
Synaptic ribbons (SRs) are prominent organelles that are abundant in the ribbon synapses of sensory neurons where they represent a specialization of the cytomatrix at the active zone (CAZ). SRs occur not only in neurons, but also in neuroendocrine pinealocytes where their function is still obscure. In this study, we report that pinealocyte SRs are associated with CAZ proteins such as Bassoon, Piccolo, CtBP1, Munc13-1, and the motorprotein KIF3A and, therefore, consist of a protein complex that resembles the ribbon complex of retinal and other sensory ribbon synapses. The pinealocyte ribbon complex is biochemically dynamic. Its protein composition changes in favor of Bassoon, Piccolo, and Munc13-1 at night and in favor of KIF3A during the day, whereas CtBP1 is equally present during the night and day. The diurnal dynamics of the ribbon complex persist under constant darkness and decrease after stimulus deprivation of the pineal gland by constant light. Our findings indicate that neuroendocrine pinealocytes possess a protein complex that resembles the CAZ of ribbon synapses in sensory organs and whose dynamics are under circadian regulation.
Date of acceptance
2008
Autoren
  • Isabella Spiwoks-Becker
  • Christian Maus
  • Susanne tom Dieck
  • Anna Fejtová
  • Lydia Engel
  • Tanja Wolloscheck
  • Uwe Wolfrum
  • Lutz Vollrath
  • Rainer Spessert
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/18523806
DOI
10.1007/s00441-008-0627-3
Externe Identifier
  • PubMed Central ID: PMC2757586
ISSN
0302-766X
Ausgabe der Veröffentlichung
2
Zeitschrift
Cell Tissue Res
Schlüsselwörter
  • Animals
  • Circadian Rhythm
  • Cytoskeletal Proteins
  • Darkness
  • Eye Proteins
  • Female
  • Kinesins
  • Light
  • Male
  • Nerve Tissue Proteins
  • Neuropeptides
  • Photoreceptor Cells, Vertebrate
  • Pineal Gland
  • Rats
  • Rats, Sprague-Dawley
  • Synapses
  • Synaptic Membranes
  • Synaptic Transmission
Sprache
eng
Country
Germany
Paginierung
185 - 195
Datum der Veröffentlichung
2008
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2008
Titel
Active zone proteins are dynamically associated with synaptic ribbons in rat pinealocytes.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
333

Data source: PubMed

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