Different Roles for KIF17 and Kinesin II in Photoreceptor Development and Maintenance

Publication type:
Journal article
Metadata:
Autoren
  • Christine Insinna
  • Monica Humby
  • Tina Sedmak
  • Uwe Wolfrum
  • Joseph C Besharse
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000269686400009&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/dvdy.21956
eISSN
1097-0177
Externe Identifier
  • Clarivate Analytics Document Solution ID: 492UT
  • PubMed Identifier: 19384852
ISSN
1058-8388
Ausgabe der Veröffentlichung
9
Zeitschrift
DEVELOPMENTAL DYNAMICS
Schlüsselwörter
  • KIF17
  • kinesin II
  • photoreceptors
  • ciliogenesis
  • IFT
Paginierung
2211 - 2222
Datum der Veröffentlichung
2009
Status
Published
Titel
Different Roles for KIF17 and Kinesin II in Photoreceptor Development and Maintenance
Sub types
  • Article
Ausgabe der Zeitschrift
238

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:title>Abstract</jats:title><jats:p>Kinesin 2 family members are involved in transport along ciliary microtubules. In <jats:italic>Caenorhabditis elegans</jats:italic> channel cilia, kinesin II and OSM‐3 cooperate along microtubule doublets of the axoneme middle segment, whereas OSM‐3 alone works on microtubule singlets to elongate the distal segment. Among sensory cilia, vertebrate photoreceptors share a similar axonemal structure with <jats:italic>C. elegans</jats:italic> channel cilia, and deficiency in either kinesin II or KIF17, the homologue of OSM‐3, results in disruption of photoreceptor organization. However, direct comparison of the two effects is confounded by the use of different species and knockdown strategies in prior studies. Here, we directly compare the effects of dominant‐negative kinesin II and KIF17 expression in zebrafish cone photoreceptors. Our data indicate that dominant‐negative kinesin II disrupts function at the level of the inner segment and synaptic terminal and results in cell death. In contrast, dominant‐negative KIF17 has no obvious effect on inner segment or synaptic organization but has an immediate impact on outer segment assembly. Developmental Dynamics 238:2211–2222, 2009. © 2009 Wiley‐Liss, Inc.</jats:p>
Autoren
  • Christine Insinna
  • Monica Humby
  • Tina Sedmak
  • Uwe Wolfrum
  • Joseph C Besharse
DOI
10.1002/dvdy.21956
eISSN
1097-0177
ISSN
1058-8388
Ausgabe der Veröffentlichung
9
Zeitschrift
Developmental Dynamics
Sprache
en
Online publication date
2009
Paginierung
2211 - 2222
Datum der Veröffentlichung
2009
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/dvdy.21956
Datum der Datenerfassung
2023
Titel
Different roles for KIF17 and kinesin II in photoreceptor development and maintenance
Ausgabe der Zeitschrift
238

Data source: Crossref

Abstract
Kinesin 2 family members are involved in transport along ciliary microtubules. In Caenorhabditis elegans channel cilia, kinesin II and OSM-3 cooperate along microtubule doublets of the axoneme middle segment, whereas OSM-3 alone works on microtubule singlets to elongate the distal segment. Among sensory cilia, vertebrate photoreceptors share a similar axonemal structure with C. elegans channel cilia, and deficiency in either kinesin II or KIF17, the homologue of OSM-3, results in disruption of photoreceptor organization. However, direct comparison of the two effects is confounded by the use of different species and knockdown strategies in prior studies. Here, we directly compare the effects of dominant-negative kinesin II and KIF17 expression in zebrafish cone photoreceptors. Our data indicate that dominant-negative kinesin II disrupts function at the level of the inner segment and synaptic terminal and results in cell death. In contrast, dominant-negative KIF17 has no obvious effect on inner segment or synaptic organization but has an immediate impact on outer segment assembly.
Addresses
  • Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Autoren
  • Christine Insinna
  • Monica Humby
  • Tina Sedmak
  • Uwe Wolfrum
  • Joseph C Besharse
DOI
10.1002/dvdy.21956
eISSN
1097-0177
Externe Identifier
  • PubMed Identifier: 19384852
  • PubMed Central ID: PMC2733920
Funding acknowledgements
  • NEI NIH HHS: P30 EY001931-30
  • NEI NIH HHS: R01 EY002414
  • NEI NIH HHS: R01 EY002414-33
  • NEI NIH HHS: T32 EY014537-05
  • NEI NIH HHS: R01 EY003222-27
  • NEI NIH HHS: R01 EY003222-28A2
  • NEI NIH HHS: P30 EY001931
  • NEI NIH HHS: R01 EY002414-33S1
  • NEI NIH HHS: T32 EY014537
  • NEI NIH HHS: R01 EY003222
  • NCRR NIH HHS: S10 RR015679-01
  • NEI NIH HHS: T32-EY014537
  • NEI NIH HHS: EY03222
  • NEI NIH HHS: P30 EY001931-31
  • NEI NIH HHS: T32 EY014537-06A1
Open access
false
ISSN
1058-8388
Ausgabe der Veröffentlichung
9
Zeitschrift
Developmental dynamics : an official publication of the American Association of Anatomists
Schlüsselwörter
  • Embryo, Nonmammalian
  • Animals
  • Zebrafish
  • Mice
  • Zebrafish Proteins
  • Microscopy, Electron, Transmission
  • Microscopy, Immunoelectron
  • Blotting, Western
  • Immunohistochemistry
  • Immunoprecipitation
  • Retinal Cone Photoreceptor Cells
  • Kinesins
Sprache
eng
Medium
Print
Paginierung
2211 - 2222
Datum der Veröffentlichung
2009
Status
Published
Datum der Datenerfassung
2009
Titel
Different roles for KIF17 and kinesin II in photoreceptor development and maintenance.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
  • Research Support, N.I.H., Extramural
Ausgabe der Zeitschrift
238

Files

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.21956 https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19384852/pdf/?tool=EBI https://europepmc.org/articles/PMC2733920?pdf=render

Data source: Europe PubMed Central

Abstract
Kinesin 2 family members are involved in transport along ciliary microtubules. In Caenorhabditis elegans channel cilia, kinesin II and OSM-3 cooperate along microtubule doublets of the axoneme middle segment, whereas OSM-3 alone works on microtubule singlets to elongate the distal segment. Among sensory cilia, vertebrate photoreceptors share a similar axonemal structure with C. elegans channel cilia, and deficiency in either kinesin II or KIF17, the homologue of OSM-3, results in disruption of photoreceptor organization. However, direct comparison of the two effects is confounded by the use of different species and knockdown strategies in prior studies. Here, we directly compare the effects of dominant-negative kinesin II and KIF17 expression in zebrafish cone photoreceptors. Our data indicate that dominant-negative kinesin II disrupts function at the level of the inner segment and synaptic terminal and results in cell death. In contrast, dominant-negative KIF17 has no obvious effect on inner segment or synaptic organization but has an immediate impact on outer segment assembly.
Autoren
  • Christine Insinna
  • Monica Humby
  • Tina Sedmak
  • Uwe Wolfrum
  • Joseph C Besharse
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/19384852
DOI
10.1002/dvdy.21956
eISSN
1097-0177
Externe Identifier
  • NIH Manuscript Submission ID: NIHMS121992
  • PubMed Central ID: PMC2733920
Funding acknowledgements
  • NEI NIH HHS: T32 EY014537-06A1
  • NEI NIH HHS: T32 EY014537-05
  • NEI NIH HHS: R01 EY003222-28A2
  • NEI NIH HHS: P30 EY001931-31
  • NEI NIH HHS: R01 EY002414-33
  • NEI NIH HHS: R01 EY003222-27
  • NEI NIH HHS: R01 EY002414-33S1
  • NEI NIH HHS: EY03222
  • NEI NIH HHS: P30 EY001931
  • NEI NIH HHS: R01 EY003222
  • NEI NIH HHS: T32-EY014537
  • NCRR NIH HHS: S10 RR015679-01
  • NEI NIH HHS: P30 EY001931-30
  • NEI NIH HHS: T32 EY014537
  • NEI NIH HHS: R01 EY002414
Ausgabe der Veröffentlichung
9
Zeitschrift
Dev Dyn
Schlüsselwörter
  • Animals
  • Blotting, Western
  • Embryo, Nonmammalian
  • Immunohistochemistry
  • Immunoprecipitation
  • Kinesins
  • Mice
  • Microscopy, Electron, Transmission
  • Microscopy, Immunoelectron
  • Retinal Cone Photoreceptor Cells
  • Zebrafish
  • Zebrafish Proteins
Sprache
eng
Country
United States
Paginierung
2211 - 2222
Datum der Veröffentlichung
2009
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2009
Titel
Different roles for KIF17 and kinesin II in photoreceptor development and maintenance.
Sub types
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
238

Data source: PubMed

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