BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

Publication type:
Journal article
Metadata:
Autoren
  • Martin Gamerdinger
  • A Murat Kaya
  • Uwe Wolfrum
  • Albrecht M Clement
  • Christian Behl
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000286825900014&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1038/embor.2010.203
eISSN
1469-3178
Externe Identifier
  • Clarivate Analytics Document Solution ID: 714RE
  • PubMed Identifier: 21252941
ISSN
1469-221X
Ausgabe der Veröffentlichung
2
Zeitschrift
EMBO REPORTS
Schlüsselwörter
  • ALS
  • BAG3
  • dynein
  • p62
  • ubiquitin
Paginierung
149 - 156
Datum der Veröffentlichung
2011
Status
Published
Titel
BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins
Sub types
  • Article
Ausgabe der Zeitschrift
12

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:p>Increasing evidence indicates the existence of selective autophagy pathways, but the manner in which substrates are recognized and targeted to the autophagy system is poorly understood. One strategy is transport of a particular substrate to the aggresome, a perinuclear compartment with high autophagic activity. In this paper, we identify a new cellular pathway that uses the specificity of heat‐shock protein 70 (Hsp70) to misfolded proteins as the basis for aggresome‐targeting and autophagic degradation. This pathway is regulated by the stress‐induced co‐chaperone Bcl‐2‐associated athanogene 3 (BAG3), which interacts with the microtubule‐motor dynein and selectively directs Hsp70 substrates to the motor and thereby to the aggresome. Notably, aggresome‐targeting by BAG3 is distinct from previously described mechanisms, as it does not depend on substrate ubiquitination.</jats:p>
Autoren
  • Martin Gamerdinger
  • A Murat Kaya
  • Uwe Wolfrum
  • Albrecht M Clement
  • Christian Behl
DOI
10.1038/embor.2010.203
eISSN
1469-3178
ISSN
1469-221X
Ausgabe der Veröffentlichung
2
Zeitschrift
EMBO reports
Sprache
en
Online publication date
2011
Paginierung
149 - 156
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1038/embor.2010.203
Datum der Datenerfassung
2023
Titel
BAG3 mediates chaperone‐based aggresome‐targeting and selective autophagy of misfolded proteins
Ausgabe der Zeitschrift
12

Data source: Crossref

Abstract
Increasing evidence indicates the existence of selective autophagy pathways, but the manner in which substrates are recognized and targeted to the autophagy system is poorly understood. One strategy is transport of a particular substrate to the aggresome, a perinuclear compartment with high autophagic activity. In this paper, we identify a new cellular pathway that uses the specificity of heat-shock protein 70 (Hsp70) to misfolded proteins as the basis for aggresome-targeting and autophagic degradation. This pathway is regulated by the stress-induced co-chaperone Bcl-2-associated athanogene 3 (BAG3), which interacts with the microtubule-motor dynein and selectively directs Hsp70 substrates to the motor and thereby to the aggresome. Notably, aggresome-targeting by BAG3 is distinct from previously described mechanisms, as it does not depend on substrate ubiquitination.
Addresses
  • Institute of Pathobiochemistry, University Medical Center, Johannes Gutenberg University, Duesbergweg 6, Mainz 55099, Germany.
Autoren
  • Martin Gamerdinger
  • A Murat Kaya
  • Uwe Wolfrum
  • Albrecht M Clement
  • Christian Behl
DOI
10.1038/embor.2010.203
eISSN
1469-3178
Externe Identifier
  • PubMed Identifier: 21252941
  • PubMed Central ID: PMC3049430
Open access
false
ISSN
1469-221X
Ausgabe der Veröffentlichung
2
Zeitschrift
EMBO reports
Schlüsselwörter
  • Spinal Cord
  • Motor Neurons
  • COS Cells
  • Inclusion Bodies
  • Animals
  • Mice, Transgenic
  • Humans
  • Mice
  • Superoxide Dismutase
  • Adaptor Proteins, Signal Transducing
  • Green Fluorescent Proteins
  • Recombinant Fusion Proteins
  • Sequence Deletion
  • Protein Folding
  • Protein Transport
  • Point Mutation
  • Autophagy
  • HSP70 Heat-Shock Proteins
  • Apoptosis Regulatory Proteins
  • Dyneins
  • HEK293 Cells
  • Proteasome Inhibitors
  • Chlorocebus aethiops
Sprache
eng
Medium
Print-Electronic
Online publication date
2011
Paginierung
149 - 156
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2011
Titel
BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins.
Sub types
  • Research Support, Non-U.S. Gov't
  • report
  • Journal Article
Ausgabe der Zeitschrift
12

Files

http://embor.embopress.org/content/embor/12/2/149.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21252941/pdf/?tool=EBI https://europepmc.org/articles/PMC3049430?pdf=render

Data source: Europe PubMed Central

Abstract
Increasing evidence indicates the existence of selective autophagy pathways, but the manner in which substrates are recognized and targeted to the autophagy system is poorly understood. One strategy is transport of a particular substrate to the aggresome, a perinuclear compartment with high autophagic activity. In this paper, we identify a new cellular pathway that uses the specificity of heat-shock protein 70 (Hsp70) to misfolded proteins as the basis for aggresome-targeting and autophagic degradation. This pathway is regulated by the stress-induced co-chaperone Bcl-2-associated athanogene 3 (BAG3), which interacts with the microtubule-motor dynein and selectively directs Hsp70 substrates to the motor and thereby to the aggresome. Notably, aggresome-targeting by BAG3 is distinct from previously described mechanisms, as it does not depend on substrate ubiquitination.
Date of acceptance
2010
Autoren
  • Martin Gamerdinger
  • A Murat Kaya
  • Uwe Wolfrum
  • Albrecht M Clement
  • Christian Behl
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21252941
DOI
10.1038/embor.2010.203
eISSN
1469-3178
Externe Identifier
  • PubMed Central ID: PMC3049430
Ausgabe der Veröffentlichung
2
Zeitschrift
EMBO Rep
Schlüsselwörter
  • Adaptor Proteins, Signal Transducing
  • Animals
  • Apoptosis Regulatory Proteins
  • Autophagy
  • COS Cells
  • Chlorocebus aethiops
  • Dyneins
  • Green Fluorescent Proteins
  • HEK293 Cells
  • HSP70 Heat-Shock Proteins
  • Humans
  • Inclusion Bodies
  • Mice
  • Mice, Transgenic
  • Motor Neurons
  • Point Mutation
  • Proteasome Inhibitors
  • Protein Folding
  • Protein Transport
  • Recombinant Fusion Proteins
  • Sequence Deletion
  • Spinal Cord
  • Superoxide Dismutase
Sprache
eng
Country
England
Paginierung
149 - 156
PII
embor2010203
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
12

Data source: PubMed

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