International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors

Autoren

Jörg Hamann
Gabriela Aust
Demet Araç
Felix B Engel
Caroline Formstone
Robert Fredriksson
Randy A Hall
Breanne L Harty
Christiane Kirchhoff
Barbara Knapp
Arunkumar Krishnan
Ines Liebscher
Hsi-Hsien Lin
David C Martinelli
Kelly R Monk
Miriam C Peeters
Xianhua Piao
Simone Prömel
Torsten Schöneberg
Thue W Schwartz
Kathleen Singer
Martin Stacey
Yuri A Ushkaryov
Mario Vallon
Uwe Wolfrum
Mathew W Wright
Lei Xu
Tobias Langenhan
Helgi B Schiöth

DOI

10.1124/pr.114.009647

Editoren

Eliot H Ohlstein

eISSN

1521-0081

ISSN

0031-6997

Ausgabe der Veröffentlichung

2

Zeitschrift

Pharmacological Reviews

Sprache

en

Online publication date

2015

Paginierung

338 - 367

Datum der Veröffentlichung

2015

Status

Published

Herausgeber

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Herausgeber URL

http://dx.doi.org/10.1124/pr.114.009647

Datum der Datenerfassung

2023

Titel

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors

Ausgabe der Zeitschrift

67

Data source: Crossref

Abstract

The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

Addresses

Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (J.H.); Department of Surgery, Research Laboratories (G.A), and Institute of Biochemistry (I.L., S.P., T.S.), Medical Faculty, University of Leipzig, Leipzig, Germany; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois (D.A.); Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (F.B.E.); MRC Centre for Developmental Neurobiology, King's College London, London, United Kingdom (C.F.); Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden (R.F., A.K., H.B.S.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.A.H.); Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri (B.L.H., K.R.M.); Department for Andrology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (C.K.); Cell and Matrix Biology, Institute of Zoology, Johannes Gutenberg University Mainz, Mainz, Germany (B.K., U.W.); Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan (H.-H.L.); Department of Molecular and Cellular Physiology (D.C.M.) and Division of Hematology (M.V.), Stanford University School of Medicine, Stanford, California; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (M.C.P.); Department of Neuroscience and Pharmacology and Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark (M.C.P., T.W.S.); Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (X.P., K.S.); Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom (M.S.); Medway School of Pharmacy, University of Kent, Chatham, United Kingdom (Y.A.U.); HUGO Gene Nomen

Autoren

Jörg Hamann
Gabriela Aust
Demet Araç
Felix B Engel
Caroline Formstone
Robert Fredriksson
Randy A Hall
Breanne L Harty
Christiane Kirchhoff
Barbara Knapp
Arunkumar Krishnan
Ines Liebscher
Hsi-Hsien Lin
David C Martinelli
Kelly R Monk
Miriam C Peeters
Xianhua Piao
Simone Prömel
Torsten Schöneberg
Thue W Schwartz
Kathleen Singer
Martin Stacey
Yuri A Ushkaryov
Mario Vallon
Uwe Wolfrum
Mathew W Wright
Lei Xu
Tobias Langenhan
Helgi B Schiöth

DOI

10.1124/pr.114.009647

eISSN

1521-0081

Externe Identifier

PubMed Identifier: 25713288
PubMed Central ID: PMC4394687

Funding acknowledgements

NNF Center for Basic Metabolic Research: Schwartz Group
Novo Nordisk Fonden: NNF12OC1016287
Novo Nordisk Fonden: NNF13OC0005723
Novo Nordisk Fonden: NNF15OC0016184
NIGMS NIH HHS: R01 GM098591
NHGRI NIH HHS: U41 HG003345
Wellcome Trust: 099156/Z/12/Z

Open access

false

ISSN

0031-6997

Ausgabe der Veröffentlichung

2

Zeitschrift

Pharmacological reviews

Schlüsselwörter

Cell Membrane
Animals
Humans
Cell Adhesion Molecules
Receptors, G-Protein-Coupled
Protein Isoforms
Cyclic AMP
Ligands
Pharmacology
Pharmacology, Clinical
Cell Adhesion
Signal Transduction
Cell Movement
Second Messenger Systems
Models, Molecular
International Agencies
Societies, Scientific
Terminology as Topic

Sprache

eng

Medium

Print

Paginierung

338 - 367

Datum der Veröffentlichung

2015

Status

Published

Datum der Datenerfassung

2015

Titel

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

Sub types

other
Research Support, Non-U.S. Gov't
Review
Journal Article

Ausgabe der Zeitschrift

67

Files

http://pharmrev.aspetjournals.org/content/pharmrev/67/2/338.full.pdf https://europepmc.org/articles/PMC4394687?pdf=render

Data source: Europe PubMed Central

Abstract

The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

Autoren

Jörg Hamann
Gabriela Aust
Demet Araç
Felix B Engel
Caroline Formstone
Robert Fredriksson
Randy A Hall
Breanne L Harty
Christiane Kirchhoff
Barbara Knapp
Arunkumar Krishnan
Ines Liebscher
Hsi-Hsien Lin
David C Martinelli
Kelly R Monk
Miriam C Peeters
Xianhua Piao
Simone Prömel
Torsten Schöneberg
Thue W Schwartz
Kathleen Singer
Martin Stacey
Yuri A Ushkaryov
Mario Vallon
Uwe Wolfrum
Mathew W Wright
Lei Xu
Tobias Langenhan
Helgi B Schiöth

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/25713288

DOI

10.1124/pr.114.009647

eISSN

1521-0081

Externe Identifier

PubMed Central ID: PMC4394687

Funding acknowledgements

NIGMS NIH HHS: R01 GM098591
NHGRI NIH HHS: U41 HG003345
Wellcome Trust: 099156/Z/12/Z

Ausgabe der Veröffentlichung

2

Zeitschrift

Pharmacol Rev

Schlüsselwörter

Animals
Cell Adhesion
Cell Adhesion Molecules
Cell Membrane
Cell Movement
Cyclic AMP
Humans
International Agencies
Ligands
Models, Molecular
Pharmacology
Pharmacology, Clinical
Protein Isoforms
Receptors, G-Protein-Coupled
Second Messenger Systems
Signal Transduction
Societies, Scientific
Terminology as Topic

Sprache

eng

Country

United States

Paginierung

338 - 367

PII

67/2/338

Datum der Veröffentlichung

2015

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2015

Titel

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

Sub types

Journal Article
Research Support, Non-U.S. Gov't
Review

Ausgabe der Zeitschrift

67

Data source: PubMed

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors

Files

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