Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Celine Jaillard
- Aurelie Mouret
- Marie-Laure Niepon
- Emmanuelle Clerin
- Ying Yang
- Irene Lee-Rivera
- Najate Ait-Ali
- Geraldine Millet-Puel
- Therese Cronin
- Tina Sedmak
- Wolfgang Raffelsberger
- Bernd Kinzel
- Alain Trembleau
- Olivier Poch
- Jean Bennett
- Uwe Wolfrum
- Pierre-Marie Lledo
- Jose-Alain Sahel
- Thierry Leveillard
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000303333700014&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1093/hmg/dds050
- eISSN
- 1460-2083
- Externe Identifier
- Clarivate Analytics Document Solution ID: 933BH
- PubMed Identifier: 22343139
- ISSN
- 0964-6906
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- HUMAN MOLECULAR GENETICS
- Paginierung
- 2298 - 2311
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- <i>Nxnl2</i> splicing results in dual functions in neuronal cell survival and maintenance of cell integrity
- Sub types
- Article
- Ausgabe der Zeitschrift
- 21
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Céline Jaillard
- Aurélie Mouret
- Marie-Laure Niepon
- Emmanuelle Clérin
- Ying Yang
- Irene Lee-Rivera
- Najate Aït-Ali
- Géraldine Millet-Puel
- Thérèse Cronin
- Tina Sedmak
- Wolfgang Raffelsberger
- Bernd Kinzel
- Alain Trembleau
- Olivier Poch
- Jean Bennett
- Uwe Wolfrum
- Pierre-Marie Lledo
- José-Alain Sahel
- Thierry Léveillard
- DOI
- 10.1093/hmg/dds050
- eISSN
- 1460-2083
- ISSN
- 0964-6906
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Human Molecular Genetics
- Sprache
- en
- Online publication date
- 2012
- Paginierung
- 2298 - 2311
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Herausgeber
- Oxford University Press (OUP)
- Herausgeber URL
- http://dx.doi.org/10.1093/hmg/dds050
- Datum der Datenerfassung
- 2019
- Titel
- Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity
- Ausgabe der Zeitschrift
- 21
Data source: Crossref
- Abstract
- The rod-derived cone viability factors, RdCVF and RdCVF2, have potential therapeutical interests for the treatment of inherited photoreceptor degenerations. In the mouse lacking Nxnl2, the gene encoding RdCVF2, the progressive decline of the visual performance of the cones in parallel with their degeneration, arises due to the loss of trophic support from RdCVF2. In contrary, the progressive loss of rod visual function of the Nxnl2-/- mouse results from a decrease in outer segment length, mediated by a cell autonomous mechanism involving the putative thioredoxin protein RdCVF2L, the second spliced product of the Nxnl2 gene. This novel signaling mechanism extends to olfaction as shown by the progressive impairment of olfaction in aged Nxnl2-/- mice and the protection of olfactory neurons by RdCVF2. This study shows that Nxnl2 is a bi-functional gene involved in the maintenance of both the function and the viability of sensory neurons.
- Addresses
- Institut de la vision, INSERM, U968, Paris F-75012, France.
- Autoren
- Céline Jaillard
- Aurélie Mouret
- Marie-Laure Niepon
- Emmanuelle Clérin
- Ying Yang
- Irene Lee-Rivera
- Najate Aït-Ali
- Géraldine Millet-Puel
- Thérèse Cronin
- Tina Sedmak
- Wolfgang Raffelsberger
- Bernd Kinzel
- Alain Trembleau
- Olivier Poch
- Jean Bennett
- Uwe Wolfrum
- Pierre-Marie Lledo
- José-Alain Sahel
- Thierry Léveillard
- DOI
- 10.1093/hmg/dds050
- eISSN
- 1460-2083
- Externe Identifier
- PubMed Identifier: 22343139
- PubMed Central ID: PMC3664437
- Open access
- false
- ISSN
- 0964-6906
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Human molecular genetics
- Schlüsselwörter
- Cells, Cultured
- Animals
- Mice
- Eye Proteins
- Cell Survival
- RNA Splicing
- Thioredoxins
- Sensory Receptor Cells
- Retinal Rod Photoreceptor Cells
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2012
- Paginierung
- 2298 - 2311
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum der Datenerfassung
- 2012
- Titel
- Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 21
Data source: Europe PubMed Central
- Abstract
- The rod-derived cone viability factors, RdCVF and RdCVF2, have potential therapeutical interests for the treatment of inherited photoreceptor degenerations. In the mouse lacking Nxnl2, the gene encoding RdCVF2, the progressive decline of the visual performance of the cones in parallel with their degeneration, arises due to the loss of trophic support from RdCVF2. In contrary, the progressive loss of rod visual function of the Nxnl2-/- mouse results from a decrease in outer segment length, mediated by a cell autonomous mechanism involving the putative thioredoxin protein RdCVF2L, the second spliced product of the Nxnl2 gene. This novel signaling mechanism extends to olfaction as shown by the progressive impairment of olfaction in aged Nxnl2-/- mice and the protection of olfactory neurons by RdCVF2. This study shows that Nxnl2 is a bi-functional gene involved in the maintenance of both the function and the viability of sensory neurons.
- Autoren
- Céline Jaillard
- Aurélie Mouret
- Marie-Laure Niepon
- Emmanuelle Clérin
- Ying Yang
- Irene Lee-Rivera
- Najate Aït-Ali
- Géraldine Millet-Puel
- Thérèse Cronin
- Tina Sedmak
- Wolfgang Raffelsberger
- Bernd Kinzel
- Alain Trembleau
- Olivier Poch
- Jean Bennett
- Uwe Wolfrum
- Pierre-Marie Lledo
- José-Alain Sahel
- Thierry Léveillard
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/22343139
- DOI
- 10.1093/hmg/dds050
- eISSN
- 1460-2083
- Externe Identifier
- NIH Manuscript Submission ID: HALMS675213
- PubMed Central ID: PMC3664437
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Hum Mol Genet
- Schlüsselwörter
- Animals
- Cell Survival
- Cells, Cultured
- Eye Proteins
- Mice
- RNA Splicing
- Retinal Rod Photoreceptor Cells
- Sensory Receptor Cells
- Thioredoxins
- Sprache
- eng
- Country
- England
- Paginierung
- 2298 - 2311
- PII
- dds050
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 21
Data source: PubMed
- Beziehungen:
- Property of