Getting in (and out of) the loop: regulating higher order telomere structures

Abstract

The DNA at the ends of linear chromosomes (the telomere) folds back onto itself and forms an intramolecular lariat-like structure. Although the telomere loop has been implicated in the protection of chromosome ends from nuclease-mediated resection and unscheduled DNA repair activities, it potentially poses an obstacle to the DNA replication machinery during S-phase. Therefore, the coordinated regulation of telomere loop formation, maintenance, and resolution is required in order to establish a balance between protecting the chromosome ends and promoting their duplication prior to cell division. Until recently, the only factor known to influence telomere looping in human cells was TRF2, a component of the shelterin complex. Recent work in yeast and mouse cells has uncovered additional regulatory factors that affect the loop structure at telomeres. In the following "perspective" we outline what is known about telomere looping and highlight the latest results regarding the regulation of this chromosome end structure. We speculate about how the manipulation of the telomere loop may have therapeutic implications in terms of diseases associated with telomere dysfunction and uncontrolled proliferation.

Addresses

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz Heidelberg, Germany.

Autoren

Sarah Luke-Glaser
Heiko Poschke
Brian Luke

DOI

10.3389/fonc.2012.00180

eISSN

2234-943X

Externe Identifier

PubMed Identifier: 23226680
PubMed Central ID: PMC3510458

Open access

true

ISSN

2234-943X

Zeitschrift

Frontiers in oncology

Sprache

eng

Medium

Electronic-eCollection

Online publication date

2012

Open access status

Open Access

Paginierung

180

Datum der Veröffentlichung

2012

Status

Published

Publisher licence

CC BY

Datum der Datenerfassung

2012

Titel

Getting in (and out of) the loop: regulating higher order telomere structures.

Sub types

research-article
Journal Article

Ausgabe der Zeitschrift

2

Files

https://www.frontiersin.org/articles/10.3389/fonc.2012.00180/pdf https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23226680/pdf/?tool=EBI https://europepmc.org/articles/PMC3510458?pdf=render

Data source: Europe PubMed Central

Abstract

The DNA at the ends of linear chromosomes (the telomere) folds back onto itself and forms an intramolecular lariat-like structure. Although the telomere loop has been implicated in the protection of chromosome ends from nuclease-mediated resection and unscheduled DNA repair activities, it potentially poses an obstacle to the DNA replication machinery during S-phase. Therefore, the coordinated regulation of telomere loop formation, maintenance, and resolution is required in order to establish a balance between protecting the chromosome ends and promoting their duplication prior to cell division. Until recently, the only factor known to influence telomere looping in human cells was TRF2, a component of the shelterin complex. Recent work in yeast and mouse cells has uncovered additional regulatory factors that affect the loop structure at telomeres. In the following "perspective" we outline what is known about telomere looping and highlight the latest results regarding the regulation of this chromosome end structure. We speculate about how the manipulation of the telomere loop may have therapeutic implications in terms of diseases associated with telomere dysfunction and uncontrolled proliferation.

Date of acceptance

2012

Autoren

Sarah Luke-Glaser
Heiko Poschke
Brian Luke

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/23226680

DOI

10.3389/fonc.2012.00180

eISSN

2234-943X

Externe Identifier

PubMed Central ID: PMC3510458

Zeitschrift

Front Oncol

Schlüsselwörter

Mph1
RTEL1
cancer
end protection
t-loop
telomere

Sprache

eng

Country

Switzerland

Paginierung

180

Datum der Veröffentlichung

2012

Status

Published online

Datum, an dem der Datensatz öffentlich gemacht wurde

2012

Titel

Getting in (and out of) the loop: regulating higher order telomere structures.

Sub types

Journal Article

Ausgabe der Zeitschrift

2

Data source: PubMed

Abstract

The DNA at the ends of linear chromosomes (the telomere) folds back onto itself and forms an intramolecular lariat-like structure. Although the telomere loop has been implicated in the protection of chromosome ends from nuclease-mediated resection and unscheduled DNA repair activities, it potentially poses an obstacle to the DNA replication machinery during S-phase. Therefore, the coordinated regulation of telomere loop formation, maintenance, and resolution is required in order to establish a balance between protecting the chromosome ends and promoting their duplication prior to cell division. Until recently, the only factor known to influence telomere looping in human cells was TRF2, a component of the shelterin complex. Recent work in yeast and mouse cells has uncovered additional regulatory factors that affect the loop structure at telomeres. In the following \textquotedblperspective\textquotedbl we outline what is known about telomere looping and highlight the latest results regarding the regulation of this chromosome end structure. We speculate about how the manipulation of the telomere loop may have therapeutic implications in terms of diseases associated with telomere dysfunction and uncontrolled proliferation.

Autoren

Sarah Luke-Glaser
Heiko Poschke
Brian Luke

DOI

10.3389/fonc.2012.00180

Zeitschrift

Frontiers in oncology

Paginierung

180 - 180

Datum der Veröffentlichung

2012

Datum der Datenerfassung

2023

Titel

Getting in (and out of) the loop: regulating higher order telomere structures

Sub types

article

Ausgabe der Zeitschrift

2

Data source: Manual

Getting in (and out of) the loop: regulating higher order telomere structures

Files

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