Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Heiko Poschke
- Martina Dees
- Michael Chang
- Sandeep Amberkar
- Lars Kaderali
- Rodney Rothstein
- Brian Luke
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000309817900035&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1371/journal.pgen.1002960
- Externe Identifier
- Clarivate Analytics Document Solution ID: 020NK
- PubMed Identifier: 23028367
- ISSN
- 1553-7404
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- PLOS GENETICS
- Artikelnummer
- ARTN e1002960
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- Rif2 Promotes a Telomere Fold-Back Structure through Rpd3L Recruitment in Budding Yeast
- Sub types
- Article
- Ausgabe der Zeitschrift
- 8
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Heiko Poschke
- Martina Dees
- Michael Chang
- Sandeep Amberkar
- Lars Kaderali
- Rodney Rothstein
- Brian Luke
- DOI
- 10.1371/journal.pgen.1002960
- Editoren
- Jack D Griffith
- eISSN
- 1553-7404
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- PLoS Genetics
- Sprache
- en
- Online publication date
- 2012
- Paginierung
- e1002960 - e1002960
- Status
- Published online
- Herausgeber
- Public Library of Science (PLoS)
- Herausgeber URL
- http://dx.doi.org/10.1371/journal.pgen.1002960
- Datum der Datenerfassung
- 2018
- Titel
- Rif2 Promotes a Telomere Fold-Back Structure through Rpd3L Recruitment in Budding Yeast
- Ausgabe der Zeitschrift
- 8
Data source: Crossref
- Abstract
- Using a genome-wide screening approach, we have established the genetic requirements for proper telomere structure in Saccharomyces cerevisiae. We uncovered 112 genes, many of which have not previously been implicated in telomere function, that are required to form a fold-back structure at chromosome ends. Among other biological processes, lysine deacetylation, through the Rpd3L, Rpd3S, and Hda1 complexes, emerged as being a critical regulator of telomere structure. The telomeric-bound protein, Rif2, was also found to promote a telomere fold-back through the recruitment of Rpd3L to telomeres. In the absence of Rpd3 function, telomeres have an increased susceptibility to nucleolytic degradation, telomere loss, and the initiation of premature senescence, suggesting that an Rpd3-mediated structure may have protective functions. Together these data reveal that multiple genetic pathways may directly or indirectly impinge on telomere structure, thus broadening the potential targets available to manipulate telomere function.
- Addresses
- Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.
- Autoren
- Heiko Poschke
- Martina Dees
- Michael Chang
- Sandeep Amberkar
- Sandeep Amberkar
- Lars Kaderali
- Rodney Rothstein
- Brian Luke
- DOI
- 10.1371/journal.pgen.1002960
- eISSN
- 1553-7404
- Externe Identifier
- PubMed Identifier: 23028367
- PubMed Central ID: PMC3447961
- Funding acknowledgements
- NIGMS NIH HHS: GM50237
- NIGMS NIH HHS: R01 GM050237
- NIGMS NIH HHS: R37 GM050237
- Open access
- true
- ISSN
- 1553-7390
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- PLoS genetics
- Schlüsselwörter
- Chromosomes
- Chromatin
- Telomere
- Saccharomyces cerevisiae
- Histone Deacetylases
- Lysine
- Telomere-Binding Proteins
- Saccharomyces cerevisiae Proteins
- Acetylation
- Mutation
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2012
- Open access status
- Open Access
- Paginierung
- e1002960
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2012
- Titel
- Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Research Support, N.I.H., Extramural
- Ausgabe der Zeitschrift
- 8
Files
https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002960&type=printable https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028367/pdf/?tool=EBI https://europepmc.org/articles/PMC3447961?pdf=render
Data source: Europe PubMed Central
- Abstract
- Using a genome-wide screening approach, we have established the genetic requirements for proper telomere structure in Saccharomyces cerevisiae. We uncovered 112 genes, many of which have not previously been implicated in telomere function, that are required to form a fold-back structure at chromosome ends. Among other biological processes, lysine deacetylation, through the Rpd3L, Rpd3S, and Hda1 complexes, emerged as being a critical regulator of telomere structure. The telomeric-bound protein, Rif2, was also found to promote a telomere fold-back through the recruitment of Rpd3L to telomeres. In the absence of Rpd3 function, telomeres have an increased susceptibility to nucleolytic degradation, telomere loss, and the initiation of premature senescence, suggesting that an Rpd3-mediated structure may have protective functions. Together these data reveal that multiple genetic pathways may directly or indirectly impinge on telomere structure, thus broadening the potential targets available to manipulate telomere function.
- Date of acceptance
- 2012
- Autoren
- Heiko Poschke
- Martina Dees
- Michael Chang
- Sandeep Amberkar
- Lars Kaderali
- Rodney Rothstein
- Brian Luke
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/23028367
- DOI
- 10.1371/journal.pgen.1002960
- eISSN
- 1553-7404
- Externe Identifier
- PubMed Central ID: PMC3447961
- Funding acknowledgements
- NIGMS NIH HHS: R01 GM050237
- NIGMS NIH HHS: R37 GM050237
- NIGMS NIH HHS: GM50237
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- PLoS Genet
- Schlüsselwörter
- Acetylation
- Chromatin
- Chromosomes
- Histone Deacetylases
- Lysine
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Telomere
- Telomere-Binding Proteins
- Sprache
- eng
- Country
- United States
- Paginierung
- e1002960
- PII
- PGENETICS-D-12-01394
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2013
- Titel
- Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast.
- Sub types
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 8
Data source: PubMed
- Abstract
- Using a genome-wide screening approach, we have established the genetic requirements for proper telomere structure in Saccharomyces cerevisiae. We uncovered 112 genes, many of which have not previously been implicated in telomere function, that are required to form a fold-back structure at chromosome ends. Among other biological processes, lysine deacetylation, through the Rpd3L, Rpd3S, and Hda1 complexes, emerged as being a critical regulator of telomere structure. The telomeric-bound protein, Rif2, was also found to promote a telomere fold-back through the recruitment of Rpd3L to telomeres. In the absence of Rpd3 function, telomeres have an increased susceptibility to nucleolytic degradation, telomere loss, and the initiation of premature senescence, suggesting that an Rpd3-mediated structure may have protective functions. Together these data reveal that multiple genetic pathways may directly or indirectly impinge on telomere structure, thus broadening the potential targets available to manipulate telomere function.
- Autoren
- Heiko Poschke
- Martina Dees
- Michael Chang
- Sandeep Amberkar
- Lars Kaderali
- Rodney Rothstein
- Brian Luke
- DOI
- 10.1371/journal.pgen.1002960
- Zeitschrift
- PLoS genetics
- Notes
- keywords: Acetylation;Chromatin/genetics;Chromosomes/genetics;Histone Deacetylases/genetics/metabolism;Lysine/genetics/metabolism;Mutation;Saccharomyces cerevisiae Proteins/genetics/metabolism;Saccharomyces cerevisiae/genetics;Telomere/genetics;Telomere-Binding Proteins/genetics/metabolism
- Artikelnummer
- 9
- Paginierung
- e1002960 - e1002960
- Datum der Veröffentlichung
- 2012
- Datum der Datenerfassung
- 2023
- Titel
- Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast
- Sub types
- article
- Ausgabe der Zeitschrift
- 8
Data source: Manual
- Beziehungen:
- Property of