Glutamine Codon Usage and polyQ Evolution in Primates Depend on the Q Stretch Length

Autoren

Pablo Mier
Miguel A Andrade-Navarro

DOI

10.1093/gbe/evy046

eISSN

1759-6653

Ausgabe der Veröffentlichung

3

Zeitschrift

Genome Biology and Evolution

Sprache

en

Online publication date

2018

Paginierung

816 - 825

Datum der Veröffentlichung

2018

Status

Published

Herausgeber

Oxford University Press (OUP)

Herausgeber URL

http://dx.doi.org/10.1093/gbe/evy046

Datum der Datenerfassung

2023

Titel

Glutamine Codon Usage and polyQ Evolution in Primates Depend on the Q Stretch Length

Ausgabe der Zeitschrift

10

Data source: Crossref

Abstract

Amino acid usage in a proteome depends mostly on its taxonomy, as it does the codon usage in transcriptomes. Here, we explore the level of variation in the codon usage of a specific amino acid, glutamine, in relation to the number of consecutive glutamine residues. We show that CAG triplets are consistently more abundant in short glutamine homorepeats (polyQ, four to eight residues) than in shorter glutamine stretches (one to three residues), leading to the evolutionary growth of the repeat region in a CAG-dependent manner. The length of orthologous polyQ regions is mostly stable in primates, particularly the short ones. Interestingly, given a short polyQ the CAG usage is higher in unstable-in-length orthologous polyQ regions. This indicates that CAG triplets produce the necessary instability for a glutamine stretch to grow. Proteins related to polyQ-associated diseases behave in a more extreme way, with longer glutamine stretches in human and evolutionarily closer nonhuman primates, and an overall higher CAG usage. In the light of our results, we suggest an evolutionary model to explain the glutamine codon usage in polyQ regions.

Addresses

Faculty of Biology, Johannes Gutenberg University Mainz, Germany.

Autoren

Pablo Mier
Miguel A Andrade-Navarro

DOI

10.1093/gbe/evy046

eISSN

1759-6653

Externe Identifier

PubMed Identifier: 29608721
PubMed Central ID: PMC5841385

Open access

true

ISSN

1759-6653

Ausgabe der Veröffentlichung

3

Zeitschrift

Genome biology and evolution

Schlüsselwörter

Animals
Primates
Humans
Glutamine
Peptides
Proteome
Codon
Evolution, Molecular

Sprache

eng

Medium

Print

Open access status

Open Access

Paginierung

816 - 825

Datum der Veröffentlichung

2018

Status

Published

Publisher licence

CC BY

Datum der Datenerfassung

2018

Titel

Glutamine Codon Usage and polyQ Evolution in Primates Depend on the Q Stretch Length.

Sub types

Research Support, Non-U.S. Gov't
research-article
Journal Article

Ausgabe der Zeitschrift

10

Files

https://academic.oup.com/gbe/article-pdf/10/3/816/24265272/evy046.pdf https://europepmc.org/articles/PMC5841385?pdf=render

Data source: Europe PubMed Central

Abstract

Amino acid usage in a proteome depends mostly on its taxonomy, as it does the codon usage in transcriptomes. Here, we explore the level of variation in the codon usage of a specific amino acid, glutamine, in relation to the number of consecutive glutamine residues. We show that CAG triplets are consistently more abundant in short glutamine homorepeats (polyQ, four to eight residues) than in shorter glutamine stretches (one to three residues), leading to the evolutionary growth of the repeat region in a CAG-dependent manner. The length of orthologous polyQ regions is mostly stable in primates, particularly the short ones. Interestingly, given a short polyQ the CAG usage is higher in unstable-in-length orthologous polyQ regions. This indicates that CAG triplets produce the necessary instability for a glutamine stretch to grow. Proteins related to polyQ-associated diseases behave in a more extreme way, with longer glutamine stretches in human and evolutionarily closer nonhuman primates, and an overall higher CAG usage. In the light of our results, we suggest an evolutionary model to explain the glutamine codon usage in polyQ regions.

Date of acceptance

2018

Autoren

Pablo Mier
Miguel A Andrade-Navarro

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/29608721

DOI

10.1093/gbe/evy046

eISSN

1759-6653

Externe Identifier

PubMed Central ID: PMC5841385

Ausgabe der Veröffentlichung

3

Zeitschrift

Genome Biol Evol

Schlüsselwörter

Animals
Codon
Evolution, Molecular
Glutamine
Humans
Peptides
Primates
Proteome

Sprache

eng

Country

England

Paginierung

816 - 825

PII

4916091

Datum der Veröffentlichung

2018

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2018

Titel

Glutamine Codon Usage and polyQ Evolution in Primates Depend on the Q Stretch Length.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

10

Data source: PubMed

Author's licence

CC-BY

Autoren

Pablo Mier
Miguel Andrade

Hosting institution

Universitätsbibliothek Mainz

Sammlungen

JGU-Publikationen

Resource version

Published version

DOI

10.1093/gbe/evy046

Funding acknowledgements

DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin

File(s) embargoed

false

Open access

true

ISSN

1759-6653

Ausgabe der Veröffentlichung

3

Zeitschrift

Genome biology and evolution

Schlüsselwörter

570 Biowissenschaften
570 Life sciences

Sprache

eng

Notes

Andrade, Miguel veröffentlicht unter: Andrade-Navarro, Miguel A.

Open access status

Open Access

Paginierung

816 - 825

Datum der Veröffentlichung

2018

Public URL

https://openscience.ub.uni-mainz.de/handle/20.500.12030/380

Herausgeber

Oxford Univ. Press

Herausgeber URL

http://dx.doi.org/10.1093/gbe/evy046

Datum der Datenerfassung

2018

Datum, an dem der Datensatz öffentlich gemacht wurde

2018

Zugang

Public

Titel

Glutamine codon usage and polyQ evolution in primates depend on the Q stretch length

Ausgabe der Zeitschrift

10

Files

58168.pdf

Data source: OPENSCIENCE.UB

Glutamine Codon Usage and polyQ Evolution in Primates Depend on the Q Stretch Length

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