Antiproliferative and Erythroid Differentiation of Piperazine and Triphenyl Derivatives Against K-562 Human Chronic Myelogenous Leukemia
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Antoine Michael Saab
- Michael Dobmeier
- Burkhard Koenig
- Enrica Fabri
- Alessia Finotti
- Monica Borgatti
- Maria Lampronti
- Francesco Bernardi
- Thomas Efferth
- Roberto Gambari
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000322559300007&DestLinkType=FullRecord&DestApp=WOS_CPL
- eISSN
- 1791-7530
- Externe Identifier
- Clarivate Analytics Document Solution ID: 193KS
- PubMed Identifier: 23898056
- ISSN
- 0250-7005
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- ANTICANCER RESEARCH
- Schlüsselwörter
- Antiproliferative activity
- piperazine derivatives
- triphenyl derivatives
- erythroid differentiation
- anticancer agents
- Paginierung
- 3027 - 3032
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Titel
- Antiproliferative and Erythroid Differentiation of Piperazine and Triphenyl Derivatives Against K-562 Human Chronic Myelogenous Leukemia
- Sub types
- Article
- Ausgabe der Zeitschrift
- 33
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- Five piperazine derivatives (S)-4-benzyl-1-(4-bromo-3-methylphenyl)-2 methylpiperazine (A), (S)-1-benzyl-3-isobutylpiperazine-2,5-dione (B), (S)-1-benzyl-3 methylpiperazine-2,5-dione (C), (S)-1,3-dibenzylpiperazine-2,5-dione (D), (E)-1-(3-methyl 4-((E)-3-(2-methylpropylidene) piperazin-1-yl) phenyl)-2-(2 methylpropylidene) piperazine (E) and triphenyl derivative ammonium 2-((2,3',3''-trimethyl-[1,1':4',1''-terphenyl]-4 yl)oxy)acetate (F) were tested for inhibition of K-562 cell proliferation and for induction of erythroid differentiation. Among them, two piperazine and one triphenyl derivatives, compounds A, E, and F inhibited the proliferation of the K562 cell lines exhibiting inhibition concentration 50 (IC50) (IC50) of values 30.10±1.6, 4.60±0.4 and 25.70±1.10 μg ml(-1), respectively. If compound A and F were added to suboptimal concentrations of the established anticancer drugs cytosine arabinoside or mithramycin, pronounced synergic effects were observed.
- Addresses
- Chemistry Department, Faculty of Sciences II, Lebanese University, Fanar, Beirut, Lebanon. antsaab@gmail.com
- Autoren
- Antoine Michael Saab
- Michael Dobmeier
- Burkhard Koenig
- Enrica Fabri
- Alessia Finotti
- Monica Borgatti
- Ilaria Lampronti
- Francesco Bernardi
- Thomas Efferth
- Roberto Gambari
- eISSN
- 1791-7530
- Externe Identifier
- PubMed Identifier: 23898056
- Open access
- false
- ISSN
- 0250-7005
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Anticancer research
- Schlüsselwörter
- K562 Cells
- Erythroid Cells
- Humans
- Terphenyl Compounds
- Piperazines
- Plicamycin
- Cell Death
- Cell Differentiation
- Cell Proliferation
- Dose-Response Relationship, Drug
- Drug Synergism
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Piperazine
- Sprache
- eng
- Medium
- Paginierung
- 3027 - 3032
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Datum der Datenerfassung
- 2013
- Titel
- Antiproliferative and erythroid differentiation of piperazine and triphenyl derivatives against k-562 human chronic myelogenous leukemia.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 33
Datenquelle: Europe PubMed Central
- Abstract
- Five piperazine derivatives (S)-4-benzyl-1-(4-bromo-3-methylphenyl)-2 methylpiperazine (A), (S)-1-benzyl-3-isobutylpiperazine-2,5-dione (B), (S)-1-benzyl-3 methylpiperazine-2,5-dione (C), (S)-1,3-dibenzylpiperazine-2,5-dione (D), (E)-1-(3-methyl 4-((E)-3-(2-methylpropylidene) piperazin-1-yl) phenyl)-2-(2 methylpropylidene) piperazine (E) and triphenyl derivative ammonium 2-((2,3',3''-trimethyl-[1,1':4',1''-terphenyl]-4 yl)oxy)acetate (F) were tested for inhibition of K-562 cell proliferation and for induction of erythroid differentiation. Among them, two piperazine and one triphenyl derivatives, compounds A, E, and F inhibited the proliferation of the K562 cell lines exhibiting inhibition concentration 50 (IC50) (IC50) of values 30.10±1.6, 4.60±0.4 and 25.70±1.10 μg ml(-1), respectively. If compound A and F were added to suboptimal concentrations of the established anticancer drugs cytosine arabinoside or mithramycin, pronounced synergic effects were observed.
- Autoren
- Antoine Michael Saab
- Michael Dobmeier
- Burkhard Koenig
- Enrica Fabri
- Alessia Finotti
- Monica Borgatti
- Ilaria Lampronti
- Francesco Bernardi
- Thomas Efferth
- Roberto Gambari
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/23898056
- eISSN
- 1791-7530
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Anticancer Res
- Schlüsselwörter
- Antiproliferative activity
- anticancer agents
- erythroid differentiation
- piperazine derivatives
- triphenyl derivatives
- Cell Death
- Cell Differentiation
- Cell Proliferation
- Dose-Response Relationship, Drug
- Drug Synergism
- Erythroid Cells
- Humans
- K562 Cells
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Piperazine
- Piperazines
- Plicamycin
- Terphenyl Compounds
- Sprache
- eng
- Country
- Greece
- Paginierung
- 3027 - 3032
- PII
- 33/8/3027
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2013
- Titel
- Antiproliferative and erythroid differentiation of piperazine and triphenyl derivatives against k-562 human chronic myelogenous leukemia.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 33
Datenquelle: PubMed
- Beziehungen:
- Eigentum von