Leishmaniasis: Drug resistance and natural products (Review)
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Tilman Polonio
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000259519400002&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3892/ijmm_00000020
- eISSN
- 1791-244X
- Externe Identifier
- Clarivate Analytics Document Solution ID: 352TD
- PubMed Identifier: 18698485
- ISSN
- 1107-3756
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Schlüsselwörter
- anti-viral agents
- chemotherapy
- drug resistance
- leishmaniasis
- natural products
- pharmacognosy
- Paginierung
- 277 - 286
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Titel
- Leishmaniasis: Drug resistance and natural products (Review)
- Sub types
- Article
- Ausgabe der Zeitschrift
- 22
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Polonio
- DOI
- 10.3892/ijmm_00000020
- ISSN
- 1107-3756
- Zeitschrift
- International Journal of Molecular Medicine
- Datum der Veröffentlichung
- 1998
- Status
- Published
- Herausgeber
- Spandidos Publications
- Herausgeber URL
- http://dx.doi.org/10.3892/ijmm_00000020
- Datum der Datenerfassung
- 2017
- Titel
- Leishmaniasis: Drug resistance and natural products (Review)
Datenquelle: Crossref
- Abstract
- Epidemics of fatal visceral leishmaniasis caused by the intracellular protozoan Leishmania are a severe public health problem in tropical and subtropical regions of the world. One major drawback in the treatment of leishmaniasis is the emergence of resistance to current chemotherapeutics. Leishmanicidals have to be administered in low doses since commonly used drugs exhibit severe side effects, and hence drug resistance can appear rapidly. Since, to date, vaccination approaches have failed to enter clinical trials, chemotherapy based on small molecules is temporarily the exclusive treatment strategy. There is an urgent need for adding novel drugs with improved features to the pool of current chemotherapeutics. Many compounds derived from natural sources have pharmacological activities and may, thus, be of potential utility in drug development and biomedical research. Natural products, primarily plant-derived substances of diverse structural classes, have been described in the literature showing anti-leishmanial properties. In this review we provide a brief overview of the current treatment and the active principles of established drugs. Furthermore, we focus on the mechanisms of drug resistance and natural products that are promising leads for the development of novel chemotherapeutics.
- Addresses
- Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany.
- Autoren
- Tilman Polonio
- Thomas Efferth
- eISSN
- 1791-244X
- Externe Identifier
- PubMed Identifier: 18698485
- Open access
- false
- ISSN
- 1107-3756
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- International journal of molecular medicine
- Schlüsselwörter
- Animals
- Humans
- Leishmaniasis
- Biological Products
- Drug Evaluation, Preclinical
- Drug Resistance
- Sprache
- eng
- Medium
- Paginierung
- 277 - 286
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Datum der Datenerfassung
- 2008
- Titel
- Leishmaniasis: drug resistance and natural products (review).
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 22
Datenquelle: Europe PubMed Central
- Abstract
- Epidemics of fatal visceral leishmaniasis caused by the intracellular protozoan Leishmania are a severe public health problem in tropical and subtropical regions of the world. One major drawback in the treatment of leishmaniasis is the emergence of resistance to current chemotherapeutics. Leishmanicidals have to be administered in low doses since commonly used drugs exhibit severe side effects, and hence drug resistance can appear rapidly. Since, to date, vaccination approaches have failed to enter clinical trials, chemotherapy based on small molecules is temporarily the exclusive treatment strategy. There is an urgent need for adding novel drugs with improved features to the pool of current chemotherapeutics. Many compounds derived from natural sources have pharmacological activities and may, thus, be of potential utility in drug development and biomedical research. Natural products, primarily plant-derived substances of diverse structural classes, have been described in the literature showing anti-leishmanial properties. In this review we provide a brief overview of the current treatment and the active principles of established drugs. Furthermore, we focus on the mechanisms of drug resistance and natural products that are promising leads for the development of novel chemotherapeutics.
- Autoren
- Tilman Polonio
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/18698485
- ISSN
- 1107-3756
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Int J Mol Med
- Schlüsselwörter
- Animals
- Biological Products
- Drug Evaluation, Preclinical
- Drug Resistance
- Humans
- Leishmaniasis
- Sprache
- eng
- Country
- Greece
- Paginierung
- 277 - 286
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2008
- Titel
- Leishmaniasis: drug resistance and natural products (review).
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 22
Datenquelle: PubMed
- Beziehungen:
- Eigentum von