Leishmaniasis: Drug resistance and natural products (Review)

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000259519400002&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3892/ijmm_00000020
eISSN
1791-244X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 352TD
  • PubMed Identifier: 18698485
ISSN
1107-3756
Ausgabe der Veröffentlichung
3
Zeitschrift
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Schlüsselwörter
  • anti-viral agents
  • chemotherapy
  • drug resistance
  • leishmaniasis
  • natural products
  • pharmacognosy
Paginierung
277 - 286
Datum der Veröffentlichung
2008
Status
Published
Titel
Leishmaniasis: Drug resistance and natural products (Review)
Sub types
  • Article
Ausgabe der Zeitschrift
22

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Polonio
DOI
10.3892/ijmm_00000020
ISSN
1107-3756
Zeitschrift
International Journal of Molecular Medicine
Datum der Veröffentlichung
1998
Status
Published
Herausgeber
Spandidos Publications
Herausgeber URL
http://dx.doi.org/10.3892/ijmm_00000020
Datum der Datenerfassung
2017
Titel
Leishmaniasis: Drug resistance and natural products (Review)

Data source: Crossref

Abstract
Epidemics of fatal visceral leishmaniasis caused by the intracellular protozoan Leishmania are a severe public health problem in tropical and subtropical regions of the world. One major drawback in the treatment of leishmaniasis is the emergence of resistance to current chemotherapeutics. Leishmanicidals have to be administered in low doses since commonly used drugs exhibit severe side effects, and hence drug resistance can appear rapidly. Since, to date, vaccination approaches have failed to enter clinical trials, chemotherapy based on small molecules is temporarily the exclusive treatment strategy. There is an urgent need for adding novel drugs with improved features to the pool of current chemotherapeutics. Many compounds derived from natural sources have pharmacological activities and may, thus, be of potential utility in drug development and biomedical research. Natural products, primarily plant-derived substances of diverse structural classes, have been described in the literature showing anti-leishmanial properties. In this review we provide a brief overview of the current treatment and the active principles of established drugs. Furthermore, we focus on the mechanisms of drug resistance and natural products that are promising leads for the development of novel chemotherapeutics.
Addresses
  • Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany.
Autoren
eISSN
1791-244X
Externe Identifier
  • PubMed Identifier: 18698485
Open access
false
ISSN
1107-3756
Ausgabe der Veröffentlichung
3
Zeitschrift
International journal of molecular medicine
Schlüsselwörter
  • Animals
  • Humans
  • Leishmaniasis
  • Biological Products
  • Drug Evaluation, Preclinical
  • Drug Resistance
Sprache
eng
Medium
Print
Paginierung
277 - 286
Datum der Veröffentlichung
2008
Status
Published
Datum der Datenerfassung
2008
Titel
Leishmaniasis: drug resistance and natural products (review).
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
22

Data source: Europe PubMed Central

Abstract
Epidemics of fatal visceral leishmaniasis caused by the intracellular protozoan Leishmania are a severe public health problem in tropical and subtropical regions of the world. One major drawback in the treatment of leishmaniasis is the emergence of resistance to current chemotherapeutics. Leishmanicidals have to be administered in low doses since commonly used drugs exhibit severe side effects, and hence drug resistance can appear rapidly. Since, to date, vaccination approaches have failed to enter clinical trials, chemotherapy based on small molecules is temporarily the exclusive treatment strategy. There is an urgent need for adding novel drugs with improved features to the pool of current chemotherapeutics. Many compounds derived from natural sources have pharmacological activities and may, thus, be of potential utility in drug development and biomedical research. Natural products, primarily plant-derived substances of diverse structural classes, have been described in the literature showing anti-leishmanial properties. In this review we provide a brief overview of the current treatment and the active principles of established drugs. Furthermore, we focus on the mechanisms of drug resistance and natural products that are promising leads for the development of novel chemotherapeutics.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/18698485
ISSN
1107-3756
Ausgabe der Veröffentlichung
3
Zeitschrift
Int J Mol Med
Schlüsselwörter
  • Animals
  • Biological Products
  • Drug Evaluation, Preclinical
  • Drug Resistance
  • Humans
  • Leishmaniasis
Sprache
eng
Country
Greece
Paginierung
277 - 286
Datum der Veröffentlichung
2008
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2008
Titel
Leishmaniasis: drug resistance and natural products (review).
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
22

Data source: PubMed

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