Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Serkan Sertel
- Tolga Eichhorn
- Judith Bauer
- Kai Hock
- Peter K Plinkert
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000306880100004&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.jnutbio.2011.04.012
- Externe Identifier
- Clarivate Analytics Document Solution ID: 980FX
- PubMed Identifier: 21865023
- ISSN
- 0955-2863
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Schlüsselwörter
- Cancer
- Curcumin
- ABC transporter
- Drug resistance
- Pharmacogenomics
- Paginierung
- 875 - 884
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives
- Sub types
- Article
- Ausgabe der Zeitschrift
- 23
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Serkan Sertel
- Tolga Eichhorn
- Judith Bauer
- Kai Hock
- Peter K Plinkert
- Thomas Efferth
- DOI
- 10.1016/j.jnutbio.2011.04.012
- ISSN
- 0955-2863
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- The Journal of Nutritional Biochemistry
- Sprache
- en
- Paginierung
- 875 - 884
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.jnutbio.2011.04.012
- Datum der Datenerfassung
- 2018
- Titel
- Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives
- Ausgabe der Zeitschrift
- 23
Datenquelle: Crossref
- Abstract
- Curcuma longa L. has long been used as a medicinal plant in traditional Chinese medicine against abdominal disorders. Its active constituent curcumin has anti-inflammatory, chemopreventive and cytotoxic properties. In the present investigation, we have analyzed the cytotoxic activity of curcumin and four derivatives. Among these compounds, ethoxycurcumintrithiadiazolaminomethylcarbonate was the most cytotoxic one. The curcumin-type compounds were not cross-resistant to standard anticancer drugs and were not involved in ATP-binding cassette transporter-mediated multidrug resistance. A combined approach of messenger RNA-based microarray profiling, COMPARE analyses and signaling pathway analyses identified genes as determinants of sensitivity and resistance to curcumin and specific signaling routes involved in cellular response to curcumin. These genes may be useful as biomarkers to develop individualized treatment options in the future. From a nutritional point of view, it is a thriving perspective to further investigate whether C. longa may be used as a spice to improve cancer therapy.
- Addresses
- Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany.
- Autoren
- Serkan Sertel
- Tolga Eichhorn
- Judith Bauer
- Kai Hock
- Peter K Plinkert
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1016/j.jnutbio.2011.04.012
- eISSN
- 1873-4847
- Externe Identifier
- PubMed Identifier: 21865023
- Open access
- false
- ISSN
- 0955-2863
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- The Journal of nutritional biochemistry
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Curcumin
- ATP-Binding Cassette Transporters
- Anti-Inflammatory Agents
- Pharmacogenetics
- Drug Resistance, Neoplasm
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2011
- Paginierung
- 875 - 884
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum der Datenerfassung
- 2011
- Titel
- Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 23
Datenquelle: Europe PubMed Central
- Abstract
- Curcuma longa L. has long been used as a medicinal plant in traditional Chinese medicine against abdominal disorders. Its active constituent curcumin has anti-inflammatory, chemopreventive and cytotoxic properties. In the present investigation, we have analyzed the cytotoxic activity of curcumin and four derivatives. Among these compounds, ethoxycurcumintrithiadiazolaminomethylcarbonate was the most cytotoxic one. The curcumin-type compounds were not cross-resistant to standard anticancer drugs and were not involved in ATP-binding cassette transporter-mediated multidrug resistance. A combined approach of messenger RNA-based microarray profiling, COMPARE analyses and signaling pathway analyses identified genes as determinants of sensitivity and resistance to curcumin and specific signaling routes involved in cellular response to curcumin. These genes may be useful as biomarkers to develop individualized treatment options in the future. From a nutritional point of view, it is a thriving perspective to further investigate whether C. longa may be used as a spice to improve cancer therapy.
- Date of acceptance
- 2011
- Autoren
- Serkan Sertel
- Tolga Eichhorn
- Judith Bauer
- Kai Hock
- Peter K Plinkert
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/21865023
- DOI
- 10.1016/j.jnutbio.2011.04.012
- eISSN
- 1873-4847
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- J Nutr Biochem
- Schlüsselwörter
- ATP-Binding Cassette Transporters
- Anti-Inflammatory Agents
- Cell Line, Tumor
- Curcumin
- Drug Resistance, Neoplasm
- Humans
- Pharmacogenetics
- Sprache
- eng
- Country
- United States
- Paginierung
- 875 - 884
- PII
- S0955-2863(11)00139-2
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 23
Datenquelle: PubMed
- Beziehungen:
- Eigentum von