Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives

Publication type:
Journal article
Metadata:
Autoren
  • Serkan Sertel
  • Tolga Eichhorn
  • Judith Bauer
  • Kai Hock
  • Peter K Plinkert
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000306880100004&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.jnutbio.2011.04.012
Externe Identifier
  • Clarivate Analytics Document Solution ID: 980FX
  • PubMed Identifier: 21865023
ISSN
0955-2863
Ausgabe der Veröffentlichung
8
Zeitschrift
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Schlüsselwörter
  • Cancer
  • Curcumin
  • ABC transporter
  • Drug resistance
  • Pharmacogenomics
Paginierung
875 - 884
Datum der Veröffentlichung
2012
Status
Published
Titel
Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives
Sub types
  • Article
Ausgabe der Zeitschrift
23

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Serkan Sertel
  • Tolga Eichhorn
  • Judith Bauer
  • Kai Hock
  • Peter K Plinkert
  • Thomas Efferth
DOI
10.1016/j.jnutbio.2011.04.012
ISSN
0955-2863
Ausgabe der Veröffentlichung
8
Zeitschrift
The Journal of Nutritional Biochemistry
Sprache
en
Paginierung
875 - 884
Datum der Veröffentlichung
2012
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.jnutbio.2011.04.012
Datum der Datenerfassung
2018
Titel
Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives
Ausgabe der Zeitschrift
23

Data source: Crossref

Abstract
Curcuma longa L. has long been used as a medicinal plant in traditional Chinese medicine against abdominal disorders. Its active constituent curcumin has anti-inflammatory, chemopreventive and cytotoxic properties. In the present investigation, we have analyzed the cytotoxic activity of curcumin and four derivatives. Among these compounds, ethoxycurcumintrithiadiazolaminomethylcarbonate was the most cytotoxic one. The curcumin-type compounds were not cross-resistant to standard anticancer drugs and were not involved in ATP-binding cassette transporter-mediated multidrug resistance. A combined approach of messenger RNA-based microarray profiling, COMPARE analyses and signaling pathway analyses identified genes as determinants of sensitivity and resistance to curcumin and specific signaling routes involved in cellular response to curcumin. These genes may be useful as biomarkers to develop individualized treatment options in the future. From a nutritional point of view, it is a thriving perspective to further investigate whether C. longa may be used as a spice to improve cancer therapy.
Addresses
  • Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany.
Autoren
  • Serkan Sertel
  • Tolga Eichhorn
  • Judith Bauer
  • Kai Hock
  • Peter K Plinkert
  • Thomas Efferth
  • Thomas Efferth
DOI
10.1016/j.jnutbio.2011.04.012
eISSN
1873-4847
Externe Identifier
  • PubMed Identifier: 21865023
Open access
false
ISSN
0955-2863
Ausgabe der Veröffentlichung
8
Zeitschrift
The Journal of nutritional biochemistry
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Curcumin
  • ATP-Binding Cassette Transporters
  • Anti-Inflammatory Agents
  • Pharmacogenetics
  • Drug Resistance, Neoplasm
Sprache
eng
Medium
Print-Electronic
Online publication date
2011
Paginierung
875 - 884
Datum der Veröffentlichung
2012
Status
Published
Datum der Datenerfassung
2011
Titel
Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
23

Data source: Europe PubMed Central

Abstract
Curcuma longa L. has long been used as a medicinal plant in traditional Chinese medicine against abdominal disorders. Its active constituent curcumin has anti-inflammatory, chemopreventive and cytotoxic properties. In the present investigation, we have analyzed the cytotoxic activity of curcumin and four derivatives. Among these compounds, ethoxycurcumintrithiadiazolaminomethylcarbonate was the most cytotoxic one. The curcumin-type compounds were not cross-resistant to standard anticancer drugs and were not involved in ATP-binding cassette transporter-mediated multidrug resistance. A combined approach of messenger RNA-based microarray profiling, COMPARE analyses and signaling pathway analyses identified genes as determinants of sensitivity and resistance to curcumin and specific signaling routes involved in cellular response to curcumin. These genes may be useful as biomarkers to develop individualized treatment options in the future. From a nutritional point of view, it is a thriving perspective to further investigate whether C. longa may be used as a spice to improve cancer therapy.
Date of acceptance
2011
Autoren
  • Serkan Sertel
  • Tolga Eichhorn
  • Judith Bauer
  • Kai Hock
  • Peter K Plinkert
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21865023
DOI
10.1016/j.jnutbio.2011.04.012
eISSN
1873-4847
Ausgabe der Veröffentlichung
8
Zeitschrift
J Nutr Biochem
Schlüsselwörter
  • ATP-Binding Cassette Transporters
  • Anti-Inflammatory Agents
  • Cell Line, Tumor
  • Curcumin
  • Drug Resistance, Neoplasm
  • Humans
  • Pharmacogenetics
Sprache
eng
Country
United States
Paginierung
875 - 884
PII
S0955-2863(11)00139-2
Datum der Veröffentlichung
2012
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2012
Titel
Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
23

Data source: PubMed

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