Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of Acacia polyacantha (Fabaceae)
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Ghislain W Fotso
- Jean Na-Iya
- Armelle T Mbaveng
- Patrick Ango Yves
- Ibrahim Demirtas
- Victor Kuete
- Yeboah Samuel
- Bathelemy Ngameni
- Thomas Efferth
- Bonaventure T Ngadjui
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000491239200009&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1080/14786419.2018.1486312
- eISSN
- 1478-6427
- Externe Identifier
- Clarivate Analytics Document Solution ID: JF2TU
- PubMed Identifier: 29936870
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- NATURAL PRODUCT RESEARCH
- Schlüsselwörter
- Acacia polyacantha
- Fabaceae
- polyacanthoside A
- 3-O-methyl-D-Chiro-inositol
- drug resistant phenotypes
- cytotoxicity
- leukemia cells
- Paginierung
- 3521 - 3526
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Titel
- Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of <i>Acacia polyacantha</i> (Fabaceae)
- Sub types
- Article
- Ausgabe der Zeitschrift
- 33
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Ghislain Fotso W.
- Jean Na-Iya
- Armelle Mbaveng T.
- Patrick Ango Yves
- Ibrahim Demirtas
- Victor Kuete
- Yeboah Samuel
- Bathelemy Ngameni
- Thomas Efferth
- Bonaventure Ngadjui T.
- DOI
- 10.1080/14786419.2018.1486312
- eISSN
- 1478-6427
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- Natural Product Research
- Sprache
- en
- Online publication date
- 2018
- Paginierung
- 3521 - 3526
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Herausgeber
- Informa UK Limited
- Herausgeber URL
- http://dx.doi.org/10.1080/14786419.2018.1486312
- Datum der Datenerfassung
- 2020
- Titel
- Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of <i>Acacia polyacantha</i> (Fabaceae)
- Ausgabe der Zeitschrift
- 33
Datenquelle: Crossref
- Abstract
- The chemical investigation of the leaves and stem bark of <i>Acacia polyacantha</i> (Fabaceae) led to the isolation of a new oleanane-type triterpenoid saponin named polyacanthoside A <b>1</b> together with fifteen known compounds. Their structures were established from spectral , mainly HRESIMS, 1D NMR and 2D NMR and by comparison with literature data. The cytotoxicity of compound <b>1</b> and the analogues <b>8</b> as well as doxorubicin was determined in a panel of 9 cancer cell lines including sensitive and drug resistant phenotypes. Unlike the analogue <b>8,</b> compound <b>1</b> as well as doxorubicin displayed cytotoxic effects in all the 9 tested cancer cell lines with IC<sub>50</sub> values ranged from 8.90 μM (towards CCRF-CEM leukemia cells) to 35.21 μM (towards HepG2 hepatocarcinoma cells) for compound <b>1</b> and from 0.02 μM (towards CCRF-CEM leukemia cells) to 66.83 μM (against CEM/ADR5000 leukemia cells) for doxorubicin.
- Addresses
- Department of Organic Chemistry, Faculty of Science, University of Yaoundé I , Yaoundé , Cameroon.
- Autoren
- Ghislain Fotso W
- Jean Na-Iya
- Armelle Mbaveng T
- Patrick Ango Yves
- Ibrahim Demirtas
- Victor Kuete
- Yeboah Samuel
- Bathelemy Ngameni
- Thomas Efferth
- Bonaventure Ngadjui T
- DOI
- 10.1080/14786419.2018.1486312
- eISSN
- 1478-6427
- Externe Identifier
- PubMed Identifier: 29936870
- Open access
- false
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- Natural product research
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Acacia
- Plant Leaves
- Oleanolic Acid
- Saponins
- Antineoplastic Agents, Phytogenic
- Drug Screening Assays, Antitumor
- Drug Resistance, Multiple
- Hep G2 Cells
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2018
- Paginierung
- 3521 - 3526
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Datum der Datenerfassung
- 2018
- Titel
- Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of <i>Acacia polyacantha</i> (Fabaceae).
- Sub types
- Video-Audio Media
- Journal Article
- Ausgabe der Zeitschrift
- 33
Datenquelle: Europe PubMed Central
- Abstract
- The chemical investigation of the leaves and stem bark of Acacia polyacantha (Fabaceae) led to the isolation of a new oleanane-type triterpenoid saponin named polyacanthoside A 1 together with fifteen known compounds. Their structures were established from spectral , mainly HRESIMS, 1D NMR and 2D NMR and by comparison with literature data. The cytotoxicity of compound 1 and the analogues 8 as well as doxorubicin was determined in a panel of 9 cancer cell lines including sensitive and drug resistant phenotypes. Unlike the analogue 8, compound 1 as well as doxorubicin displayed cytotoxic effects in all the 9 tested cancer cell lines with IC50 values ranged from 8.90 μM (towards CCRF-CEM leukemia cells) to 35.21 μM (towards HepG2 hepatocarcinoma cells) for compound 1 and from 0.02 μM (towards CCRF-CEM leukemia cells) to 66.83 μM (against CEM/ADR5000 leukemia cells) for doxorubicin.
- Autoren
- Ghislain Fotso W
- Jean Na-Iya
- Armelle Mbaveng T
- Patrick Ango Yves
- Ibrahim Demirtas
- Victor Kuete
- Yeboah Samuel
- Bathelemy Ngameni
- Thomas Efferth
- Bonaventure Ngadjui T
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/29936870
- DOI
- 10.1080/14786419.2018.1486312
- eISSN
- 1478-6427
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- Nat Prod Res
- Schlüsselwörter
- 3--methyl-D-Chiro-inositol
- Fabaceae
- cytotoxicity
- drug resistant phenotypes
- leukemia cells
- polyacanthoside A
- Acacia
- Antineoplastic Agents, Phytogenic
- Cell Line, Tumor
- Drug Resistance, Multiple
- Drug Screening Assays, Antitumor
- Hep G2 Cells
- Humans
- Oleanolic Acid
- Plant Leaves
- Saponins
- Sprache
- eng
- Country
- England
- Paginierung
- 3521 - 3526
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2019
- Titel
- Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of Acacia polyacantha (Fabaceae).
- Sub types
- Journal Article
- Video-Audio Media
- Ausgabe der Zeitschrift
- 33
Datenquelle: PubMed
- Beziehungen:
- Eigentum von