Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of Acacia polyacantha (Fabaceae)

Publication type:
Journal article
Metadata:
Autoren
  • Ghislain W Fotso
  • Jean Na-Iya
  • Armelle T Mbaveng
  • Patrick Ango Yves
  • Ibrahim Demirtas
  • Victor Kuete
  • Yeboah Samuel
  • Bathelemy Ngameni
  • Thomas Efferth
  • Bonaventure T Ngadjui
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000491239200009&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1080/14786419.2018.1486312
eISSN
1478-6427
Externe Identifier
  • Clarivate Analytics Document Solution ID: JF2TU
  • PubMed Identifier: 29936870
ISSN
1478-6419
Ausgabe der Veröffentlichung
24
Zeitschrift
NATURAL PRODUCT RESEARCH
Schlüsselwörter
  • Acacia polyacantha
  • Fabaceae
  • polyacanthoside A
  • 3-O-methyl-D-Chiro-inositol
  • drug resistant phenotypes
  • cytotoxicity
  • leukemia cells
Paginierung
3521 - 3526
Datum der Veröffentlichung
2019
Status
Published
Titel
Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of <i>Acacia polyacantha</i> (Fabaceae)
Sub types
  • Article
Ausgabe der Zeitschrift
33

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Ghislain Fotso W.
  • Jean Na-Iya
  • Armelle Mbaveng T.
  • Patrick Ango Yves
  • Ibrahim Demirtas
  • Victor Kuete
  • Yeboah Samuel
  • Bathelemy Ngameni
  • Thomas Efferth
  • Bonaventure Ngadjui T.
DOI
10.1080/14786419.2018.1486312
eISSN
1478-6427
ISSN
1478-6419
Ausgabe der Veröffentlichung
24
Zeitschrift
Natural Product Research
Sprache
en
Online publication date
2018
Paginierung
3521 - 3526
Datum der Veröffentlichung
2019
Status
Published
Herausgeber
Informa UK Limited
Herausgeber URL
http://dx.doi.org/10.1080/14786419.2018.1486312
Datum der Datenerfassung
2020
Titel
Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of <i>Acacia polyacantha</i> (Fabaceae)
Ausgabe der Zeitschrift
33

Data source: Crossref

Abstract
The chemical investigation of the leaves and stem bark of <i>Acacia polyacantha</i> (Fabaceae) led to the isolation of a new oleanane-type triterpenoid saponin named polyacanthoside A <b>1</b> together with fifteen known compounds. Their structures were established from spectral , mainly HRESIMS, 1D NMR and 2D NMR and by comparison with literature data. The cytotoxicity of compound <b>1</b> and the analogues <b>8</b> as well as doxorubicin was determined in a panel of 9 cancer cell lines including sensitive and drug resistant phenotypes. Unlike the analogue <b>8,</b> compound <b>1</b> as well as doxorubicin displayed cytotoxic effects in all the 9 tested cancer cell lines with IC<sub>50</sub> values ranged from 8.90 μM (towards CCRF-CEM leukemia cells) to 35.21 μM (towards HepG2 hepatocarcinoma cells) for compound <b>1</b> and from 0.02 μM (towards CCRF-CEM leukemia cells) to 66.83 μM (against CEM/ADR5000 leukemia cells) for doxorubicin.
Addresses
  • Department of Organic Chemistry, Faculty of Science, University of Yaoundé I , Yaoundé , Cameroon.
Autoren
  • Ghislain Fotso W
  • Jean Na-Iya
  • Armelle Mbaveng T
  • Patrick Ango Yves
  • Ibrahim Demirtas
  • Victor Kuete
  • Yeboah Samuel
  • Bathelemy Ngameni
  • Thomas Efferth
  • Bonaventure Ngadjui T
DOI
10.1080/14786419.2018.1486312
eISSN
1478-6427
Externe Identifier
  • PubMed Identifier: 29936870
Open access
false
ISSN
1478-6419
Ausgabe der Veröffentlichung
24
Zeitschrift
Natural product research
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Acacia
  • Plant Leaves
  • Oleanolic Acid
  • Saponins
  • Antineoplastic Agents, Phytogenic
  • Drug Screening Assays, Antitumor
  • Drug Resistance, Multiple
  • Hep G2 Cells
Sprache
eng
Medium
Print-Electronic
Online publication date
2018
Paginierung
3521 - 3526
Datum der Veröffentlichung
2019
Status
Published
Datum der Datenerfassung
2018
Titel
Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of <i>Acacia polyacantha</i> (Fabaceae).
Sub types
  • Video-Audio Media
  • Journal Article
Ausgabe der Zeitschrift
33

Data source: Europe PubMed Central

Abstract
The chemical investigation of the leaves and stem bark of Acacia polyacantha (Fabaceae) led to the isolation of a new oleanane-type triterpenoid saponin named polyacanthoside A 1 together with fifteen known compounds. Their structures were established from spectral , mainly HRESIMS, 1D NMR and 2D NMR and by comparison with literature data. The cytotoxicity of compound 1 and the analogues 8 as well as doxorubicin was determined in a panel of 9 cancer cell lines including sensitive and drug resistant phenotypes. Unlike the analogue 8, compound 1 as well as doxorubicin displayed cytotoxic effects in all the 9 tested cancer cell lines with IC50 values ranged from 8.90 μM (towards CCRF-CEM leukemia cells) to 35.21 μM (towards HepG2 hepatocarcinoma cells) for compound 1 and from 0.02 μM (towards CCRF-CEM leukemia cells) to 66.83 μM (against CEM/ADR5000 leukemia cells) for doxorubicin.
Autoren
  • Ghislain Fotso W
  • Jean Na-Iya
  • Armelle Mbaveng T
  • Patrick Ango Yves
  • Ibrahim Demirtas
  • Victor Kuete
  • Yeboah Samuel
  • Bathelemy Ngameni
  • Thomas Efferth
  • Bonaventure Ngadjui T
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/29936870
DOI
10.1080/14786419.2018.1486312
eISSN
1478-6427
Ausgabe der Veröffentlichung
24
Zeitschrift
Nat Prod Res
Schlüsselwörter
  • 3--methyl-D-Chiro-inositol
  • Fabaceae
  • cytotoxicity
  • drug resistant phenotypes
  • leukemia cells
  • polyacanthoside A
  • Acacia
  • Antineoplastic Agents, Phytogenic
  • Cell Line, Tumor
  • Drug Resistance, Multiple
  • Drug Screening Assays, Antitumor
  • Hep G2 Cells
  • Humans
  • Oleanolic Acid
  • Plant Leaves
  • Saponins
Sprache
eng
Country
England
Paginierung
3521 - 3526
Datum der Veröffentlichung
2019
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2019
Titel
Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of Acacia polyacantha (Fabaceae).
Sub types
  • Journal Article
  • Video-Audio Media
Ausgabe der Zeitschrift
33

Data source: PubMed

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