Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Mariana Magalhaes
- Bruno Manadas
- Thomas Efferth
- Celia Cabral
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000663005100025&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.phrs.2021.105638
- eISSN
- 1096-1186
- Externe Identifier
- Clarivate Analytics Document Solution ID: SU2XL
- PubMed Identifier: 33933637
- ISSN
- 1043-6618
- Zeitschrift
- PHARMACOLOGICAL RESEARCH
- Schlüsselwörter
- Glioblastoma
- Tumor microenvironment
- Phenolic compounds
- Essential oils
- Anticancer therapy
- Chemoprevention
- Artikelnummer
- ARTN 105638
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma
- Sub types
- Review
- Ausgabe der Zeitschrift
- 169
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Mariana Magalhães
- Bruno Manadas
- Thomas Efferth
- Célia Cabral
- DOI
- 10.1016/j.phrs.2021.105638
- ISSN
- 1043-6618
- Zeitschrift
- Pharmacological Research
- Sprache
- en
- Artikelnummer
- 105638
- Paginierung
- 105638 - 105638
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.phrs.2021.105638
- Datum der Datenerfassung
- 2023
- Titel
- Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma
- Ausgabe der Zeitschrift
- 169
Datenquelle: Crossref
- Abstract
- Glioblastoma (GBM) is the most common primary tumor of the central nervous system. Current treatments available for GBM entails surgical resection followed by temozolomide chemotherapy and/or radiotherapy, which are associated with multidrug resistance and severe side effects. While this treatment could yield good results, in almost all cases, patients suffer from relapse, which leads to reduced survival rates. Thus, therapeutic approaches with improved efficiency and reduced off-target risks are needed to overcome these problems. Regarding this, natural products appear as a safe and attractive strategy as chemotherapeutic agents or adjuvants in the treatment of GBM. Besides the increasing role of natural compounds for chemoprevention of GBM, it has been proposed to prevent carcinogenesis and metastasis of GBM. Numerous investigations showed that natural products are able to inhibit proliferation and angiogenesis, to induce apoptosis, and to target GBM stem cells, which are associated with tumor development and recurrence. This review gives a timely and comprehensive overview of the current literature regarding chemoprevention and therapy of GBM by natural products with a focus on essential oils and phenolic compounds and their molecular mechanisms.
- Addresses
- PhD Programme in Experimental Biology and Biomedicine, Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Casa Costa Alemão, 3030-789 Coimbra, Portugal; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Clinic Academic Center of Coimbra (CACC), Faculty of Medicine, 3000-548 Coimbra, Portugal; University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), 3000-548 Coimbra, Portugal.
- Autoren
- Mariana Magalhães
- Bruno Manadas
- Thomas Efferth
- Célia Cabral
- DOI
- 10.1016/j.phrs.2021.105638
- eISSN
- 1096-1186
- Externe Identifier
- PubMed Identifier: 33933637
- Funding acknowledgements
- FCT:
- European Regional Development Fund:
- Open access
- false
- ISSN
- 1043-6618
- Zeitschrift
- Pharmacological research
- Schlüsselwörter
- Animals
- Humans
- Glioblastoma
- Brain Neoplasms
- Neoplasm Recurrence, Local
- Phenols
- Oils, Volatile
- Antineoplastic Agents
- Biological Products
- Tumor Microenvironment
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2021
- Paginierung
- 105638
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum der Datenerfassung
- 2021
- Titel
- Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma.
- Sub types
- Research Support, Non-U.S. Gov't
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 169
Datenquelle: Europe PubMed Central
- Abstract
- Glioblastoma (GBM) is the most common primary tumor of the central nervous system. Current treatments available for GBM entails surgical resection followed by temozolomide chemotherapy and/or radiotherapy, which are associated with multidrug resistance and severe side effects. While this treatment could yield good results, in almost all cases, patients suffer from relapse, which leads to reduced survival rates. Thus, therapeutic approaches with improved efficiency and reduced off-target risks are needed to overcome these problems. Regarding this, natural products appear as a safe and attractive strategy as chemotherapeutic agents or adjuvants in the treatment of GBM. Besides the increasing role of natural compounds for chemoprevention of GBM, it has been proposed to prevent carcinogenesis and metastasis of GBM. Numerous investigations showed that natural products are able to inhibit proliferation and angiogenesis, to induce apoptosis, and to target GBM stem cells, which are associated with tumor development and recurrence. This review gives a timely and comprehensive overview of the current literature regarding chemoprevention and therapy of GBM by natural products with a focus on essential oils and phenolic compounds and their molecular mechanisms.
- Date of acceptance
- 2021
- Autoren
- Mariana Magalhães
- Bruno Manadas
- Thomas Efferth
- Célia Cabral
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/33933637
- DOI
- 10.1016/j.phrs.2021.105638
- eISSN
- 1096-1186
- Zeitschrift
- Pharmacol Res
- Schlüsselwörter
- Anticancer therapy
- Chemoprevention
- Essential oils
- Glioblastoma
- Phenolic compounds
- Tumor microenvironment
- Animals
- Antineoplastic Agents
- Biological Products
- Brain Neoplasms
- Glioblastoma
- Humans
- Neoplasm Recurrence, Local
- Oils, Volatile
- Phenols
- Tumor Microenvironment
- Sprache
- eng
- Country
- Netherlands
- Paginierung
- 105638
- PII
- S1043-6618(21)00222-X
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
- Ausgabe der Zeitschrift
- 169
Datenquelle: PubMed
- Beziehungen:
- Eigentum von