Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000663005100025&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phrs.2021.105638
eISSN
1096-1186
Externe Identifier
  • Clarivate Analytics Document Solution ID: SU2XL
  • PubMed Identifier: 33933637
ISSN
1043-6618
Zeitschrift
PHARMACOLOGICAL RESEARCH
Schlüsselwörter
  • Glioblastoma
  • Tumor microenvironment
  • Phenolic compounds
  • Essential oils
  • Anticancer therapy
  • Chemoprevention
Artikelnummer
ARTN 105638
Datum der Veröffentlichung
2021
Status
Published
Titel
Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma
Sub types
  • Review
Ausgabe der Zeitschrift
169

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.phrs.2021.105638
ISSN
1043-6618
Zeitschrift
Pharmacological Research
Sprache
en
Artikelnummer
105638
Paginierung
105638 - 105638
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phrs.2021.105638
Datum der Datenerfassung
2023
Titel
Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma
Ausgabe der Zeitschrift
169

Data source: Crossref

Abstract
Glioblastoma (GBM) is the most common primary tumor of the central nervous system. Current treatments available for GBM entails surgical resection followed by temozolomide chemotherapy and/or radiotherapy, which are associated with multidrug resistance and severe side effects. While this treatment could yield good results, in almost all cases, patients suffer from relapse, which leads to reduced survival rates. Thus, therapeutic approaches with improved efficiency and reduced off-target risks are needed to overcome these problems. Regarding this, natural products appear as a safe and attractive strategy as chemotherapeutic agents or adjuvants in the treatment of GBM. Besides the increasing role of natural compounds for chemoprevention of GBM, it has been proposed to prevent carcinogenesis and metastasis of GBM. Numerous investigations showed that natural products are able to inhibit proliferation and angiogenesis, to induce apoptosis, and to target GBM stem cells, which are associated with tumor development and recurrence. This review gives a timely and comprehensive overview of the current literature regarding chemoprevention and therapy of GBM by natural products with a focus on essential oils and phenolic compounds and their molecular mechanisms.
Addresses
  • PhD Programme in Experimental Biology and Biomedicine, Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Casa Costa Alemão, 3030-789 Coimbra, Portugal; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Clinic Academic Center of Coimbra (CACC), Faculty of Medicine, 3000-548 Coimbra, Portugal; University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), 3000-548 Coimbra, Portugal.
Autoren
DOI
10.1016/j.phrs.2021.105638
eISSN
1096-1186
Externe Identifier
  • PubMed Identifier: 33933637
Funding acknowledgements
  • FCT:
  • European Regional Development Fund:
Open access
false
ISSN
1043-6618
Zeitschrift
Pharmacological research
Schlüsselwörter
  • Animals
  • Humans
  • Glioblastoma
  • Brain Neoplasms
  • Neoplasm Recurrence, Local
  • Phenols
  • Oils, Volatile
  • Antineoplastic Agents
  • Biological Products
  • Tumor Microenvironment
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
105638
Datum der Veröffentlichung
2021
Status
Published
Datum der Datenerfassung
2021
Titel
Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
169

Data source: Europe PubMed Central

Abstract
Glioblastoma (GBM) is the most common primary tumor of the central nervous system. Current treatments available for GBM entails surgical resection followed by temozolomide chemotherapy and/or radiotherapy, which are associated with multidrug resistance and severe side effects. While this treatment could yield good results, in almost all cases, patients suffer from relapse, which leads to reduced survival rates. Thus, therapeutic approaches with improved efficiency and reduced off-target risks are needed to overcome these problems. Regarding this, natural products appear as a safe and attractive strategy as chemotherapeutic agents or adjuvants in the treatment of GBM. Besides the increasing role of natural compounds for chemoprevention of GBM, it has been proposed to prevent carcinogenesis and metastasis of GBM. Numerous investigations showed that natural products are able to inhibit proliferation and angiogenesis, to induce apoptosis, and to target GBM stem cells, which are associated with tumor development and recurrence. This review gives a timely and comprehensive overview of the current literature regarding chemoprevention and therapy of GBM by natural products with a focus on essential oils and phenolic compounds and their molecular mechanisms.
Date of acceptance
2021
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/33933637
DOI
10.1016/j.phrs.2021.105638
eISSN
1096-1186
Zeitschrift
Pharmacol Res
Schlüsselwörter
  • Anticancer therapy
  • Chemoprevention
  • Essential oils
  • Glioblastoma
  • Phenolic compounds
  • Tumor microenvironment
  • Animals
  • Antineoplastic Agents
  • Biological Products
  • Brain Neoplasms
  • Glioblastoma
  • Humans
  • Neoplasm Recurrence, Local
  • Oils, Volatile
  • Phenols
  • Tumor Microenvironment
Sprache
eng
Country
Netherlands
Paginierung
105638
PII
S1043-6618(21)00222-X
Datum der Veröffentlichung
2021
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
169

Data source: PubMed

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