Automated synthesis and purification of [18f]fluoro-[di-deutero]methyl tosylate

Publication type:
Journal article
Metadata:
Autoren
  • Friederike Beyerlein
  • Markus Piel
  • Sabine Hoehnemann
  • Frank Rösch
Sammlungen
  • metadata
ISSN
0362-4803
Ausgabe der Veröffentlichung
7
Zeitschrift
Journal of labelled compounds & radiopharmaceuticals
Schlüsselwörter
  • 000 Allgemeines
  • 000 Generalities
Sprache
eng
Paginierung
Seiten: 360 - 363
Datum der Veröffentlichung
2013
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/jlcr.3043
Datum der Datenerfassung
2020
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Zugang
Public
Titel
Automated synthesis and purification of [18f]fluoro-[di-deutero]methyl tosylate
Ausgabe der Zeitschrift
56

Data source: METADATA.UB

Other metadata sources:
Autoren
  • Friederike Beyerlein
  • Markus Piel
  • Sabine Hoehnemann
  • Frank Roesch
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000320775800007&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/jlcr.3043
Externe Identifier
  • Clarivate Analytics Document Solution ID: 169JH
  • PubMed Identifier: 24285440
ISSN
0362-4803
Ausgabe der Veröffentlichung
7
Zeitschrift
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Schlüsselwörter
  • automated synthesis
  • 18F-fluoromethylation
  • [18F]fluoromethyl tosylate
  • [18F]fluorine
  • PET
Paginierung
360 - 363
Datum der Veröffentlichung
2013
Status
Published
Titel
Automated synthesis and purification of [18F]fluoro-[di-deutero]methyl tosylate
Sub types
  • Article
Ausgabe der Zeitschrift
56

Data source: Web of Science (Lite)

Abstract
<jats:title>Abstract</jats:title><jats:p>Automated synthetic procedures of [<jats:sup>18</jats:sup>F]fluoro‐[<jats:italic>di‐deutero</jats:italic>]methyl tosylate on a GE TRACERlab FX F‐N module and a non‐commercial synthesis module have been developed. The syntheses included azeotropic drying of the [<jats:sup>18</jats:sup>F]fluoride, nucleophilic <jats:sup>18</jats:sup>F‐fluorination of bis(tosyloxy)‐[<jats:italic>di‐deutero</jats:italic>]methane, HPLC purification and subsequent formulation of the synthesized [<jats:sup>18</jats:sup>F]fluoro‐[<jats:italic>di‐deutero</jats:italic>]methyl tosylate (<jats:italic>d</jats:italic><jats:sub>2</jats:sub>‐[<jats:sup>18</jats:sup>F]FMT) in organic solvents. Automation shortened the total synthesis time to 50 min, resulting in an average radiochemical yield of about 50% and high radiochemical purity (&gt;98%). The possible application of this procedure to commercially available synthesis modules might be of significance for the production of deuterated <jats:sup>18</jats:sup>F‐fluoromethylated imaging probes in the future. Copyright © 2013 John Wiley &amp; Sons, Ltd.</jats:p>
Autoren
  • Friederike Beyerlein
  • Markus Piel
  • Sabine Höhnemann
  • Frank Rösch
DOI
10.1002/jlcr.3043
eISSN
1099-1344
ISSN
0362-4803
Ausgabe der Veröffentlichung
7
Zeitschrift
Journal of Labelled Compounds and Radiopharmaceuticals
Sprache
en
Online publication date
2013
Paginierung
360 - 363
Datum der Veröffentlichung
2013
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/jlcr.3043
Datum der Datenerfassung
2023
Titel
Automated synthesis and purification of [<sup>18</sup>F]fluoro‐[<i>di‐deutero</i>]methyl tosylate
Ausgabe der Zeitschrift
56

Data source: Crossref

Abstract
Automated synthetic procedures of [(18)F]fluoro-[di-deutero]methyl tosylate on a GE TRACERlab FX F-N module and a non-commercial synthesis module have been developed. The syntheses included azeotropic drying of the [(18)F]fluoride, nucleophilic (18)F-fluorination of bis(tosyloxy)-[di-deutero]methane, HPLC purification and subsequent formulation of the synthesized [(18)F]fluoro-[di-deutero]methyl tosylate (d2-[(18)F]FMT) in organic solvents. Automation shortened the total synthesis time to 50 min, resulting in an average radiochemical yield of about 50% and high radiochemical purity (>98%). The possible application of this procedure to commercially available synthesis modules might be of significance for the production of deuterated (18)F-fluoromethylated imaging probes in the future.
Addresses
  • Institute of Nuclear Chemistry, Johannes Gutenberg-University, Fritz-Strassmann-Weg 2, 55128, Mainz, Germany.
Autoren
  • Friederike Beyerlein
  • Markus Piel
  • Sabine Höhnemann
  • Frank Rösch
DOI
10.1002/jlcr.3043
eISSN
1099-1344
Externe Identifier
  • PubMed Identifier: 24285440
Open access
false
ISSN
0362-4803
Ausgabe der Veröffentlichung
7
Zeitschrift
Journal of labelled compounds & radiopharmaceuticals
Schlüsselwörter
  • Deuterium
  • Fluorine Radioisotopes
  • Benzenesulfonates
  • Isotope Labeling
  • Automation, Laboratory
  • Chemistry Techniques, Synthetic
Sprache
eng
Medium
Print-Electronic
Online publication date
2013
Paginierung
360 - 363
Datum der Veröffentlichung
2013
Status
Published
Datum der Datenerfassung
2013
Titel
Automated synthesis and purification of [18F]fluoro-[di-deutero]methyl tosylate.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
56

Data source: Europe PubMed Central

Abstract
Automated synthetic procedures of [(18)F]fluoro-[di-deutero]methyl tosylate on a GE TRACERlab FX F-N module and a non-commercial synthesis module have been developed. The syntheses included azeotropic drying of the [(18)F]fluoride, nucleophilic (18)F-fluorination of bis(tosyloxy)-[di-deutero]methane, HPLC purification and subsequent formulation of the synthesized [(18)F]fluoro-[di-deutero]methyl tosylate (d2-[(18)F]FMT) in organic solvents. Automation shortened the total synthesis time to 50 min, resulting in an average radiochemical yield of about 50% and high radiochemical purity (>98%). The possible application of this procedure to commercially available synthesis modules might be of significance for the production of deuterated (18)F-fluoromethylated imaging probes in the future.
Date of acceptance
2013
Autoren
  • Friederike Beyerlein
  • Markus Piel
  • Sabine Höhnemann
  • Frank Rösch
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/24285440
DOI
10.1002/jlcr.3043
eISSN
1099-1344
Ausgabe der Veröffentlichung
7
Zeitschrift
J Labelled Comp Radiopharm
Schlüsselwörter
  • 18F-fluoromethylation
  • PET
  • [18F]fluorine
  • [18F]fluoromethyl tosylate
  • automated synthesis
  • Automation, Laboratory
  • Benzenesulfonates
  • Chemistry Techniques, Synthetic
  • Deuterium
  • Fluorine Radioisotopes
  • Isotope Labeling
Sprache
eng
Country
England
Paginierung
360 - 363
Datum der Veröffentlichung
2013
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2014
Titel
Automated synthesis and purification of [18F]fluoro-[di-deutero]methyl tosylate.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
56

Data source: PubMed

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