Immunoglobulin kappa C predicts overall survival in node-negative breast cancer

Publication type:
Journal article
Metadata:
Autoren
  • Zonglin Chen
  • Aslihan Gerhold-Ay
  • Susanne Gebhard
  • Daniel Boehm
  • Christine Solbach
  • Antje Lebrecht
  • Marco Battista
  • Isabel Sicking
  • Christina Cotarelo
  • Cristina Cadenas
  • Rosemarie Marchan
  • Joanna D Stewart
  • Mathias Gehrmann
  • Heinz Koelbl
  • Jan G Hengstler
  • Marcus Schmidt
Sammlungen
  • metadata
ISSN
1932-6203
Ausgabe der Veröffentlichung
9
Zeitschrift
PLoS one
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Paginierung
e44741
Datum der Veröffentlichung
2012
Herausgeber
PLoS
Herausgeber URL
http://dx.doi.org/10.1371/journal.pone.0044741
Datum der Datenerfassung
2020
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Zugang
Public
Titel
Immunoglobulin kappa C predicts overall survival in node-negative breast cancer
Ausgabe der Zeitschrift
7

Data source: METADATA.UB

Other metadata sources:
Autoren
  • Zonglin Chen
  • Aslihan Gerhold-Ay
  • Susanne Gebhard
  • Daniel Boehm
  • Christine Solbach
  • Antje Lebrecht
  • Marco Battista
  • Isabel Sicking
  • Christina Cotarelo
  • Cristina Cadenas
  • Rosemarie Marchan
  • Joanna D Stewart
  • Mathias Gehrmann
  • Heinz Koelbl
  • Jan G Hengstler
  • Marcus Schmidt
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000309973900015&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1371/journal.pone.0044741
Externe Identifier
  • Clarivate Analytics Document Solution ID: 022PZ
  • PubMed Identifier: 23028600
ISSN
1932-6203
Ausgabe der Veröffentlichung
9
Zeitschrift
PLOS ONE
Artikelnummer
ARTN e44741
Datum der Veröffentlichung
2012
Status
Published
Titel
Immunoglobulin Kappa C Predicts Overall Survival in Node-Negative Breast Cancer
Sub types
  • Article
Ausgabe der Zeitschrift
7

Data source: Web of Science (Lite)

Autoren
  • Zonglin Chen
  • Aslihan Gerhold-Ay
  • Susanne Gebhard
  • Daniel Boehm
  • Christine Solbach
  • Antje Lebrecht
  • Marco Battista
  • Isabel Sicking
  • Christina Cotarelo
  • Cristina Cadenas
  • Rosemarie Marchan
  • Joanna D Stewart
  • Mathias Gehrmann
  • Heinz Koelbl
  • Jan G Hengstler
  • Marcus Schmidt
DOI
10.1371/journal.pone.0044741
Editoren
  • Robert Lafrenie
eISSN
1932-6203
Ausgabe der Veröffentlichung
9
Zeitschrift
PLoS ONE
Sprache
en
Online publication date
2012
Paginierung
e44741 - e44741
Status
Published online
Herausgeber
Public Library of Science (PLoS)
Herausgeber URL
http://dx.doi.org/10.1371/journal.pone.0044741
Datum der Datenerfassung
2018
Titel
Immunoglobulin Kappa C Predicts Overall Survival in Node-Negative Breast Cancer
Ausgabe der Zeitschrift
7

Data source: Crossref

Abstract
<h4>Background</h4>Biomarkers of the immune system are currently not used as prognostic factors in breast cancer. We analyzed the association of the B cell/plasma cell marker immunoglobulin kappa C (IGKC) and survival of untreated node-negative breast cancer patients.<h4>Material and methods</h4>IGKC expression was evaluated by immunostaining in a cohort of 335 node-negative breast cancer patients with a median follow-up of 152 months. The prognostic significance of IGKC for disease-free survival (DFS) and breast cancer-specific overall survival (OS) was evaluated with Kaplan-Meier survival analysis as well as univariate and multivariate Cox analysis adjusted for age at diagnosis, pT stage, histological grade, estrogen receptor (ER) status, progesterone receptor (PR) status, Ki-67 and human epidermal growth factor receptor 2 (HER-2) status.<h4>Results</h4>160 patients (47.7%) showed strong expression of IGKC. Univariate analysis showed that IGKC was significantly associated with DFS (P = 0.017, hazard ratio [HR] = 0.570, 95% confidence interval [CI] = 0.360-0.903) and OS (P = 0.011, HR = 0.438, 95% CI = 0.233-0.822) in the entire cohort. The significance of IGKC was especially strong in ER negative and in luminal B carcinomas. In multivariate analysis IGKC retained its significance independent of established clinical factors for DFS (P = 0.004, HR = 0.504, 95% CI = 0.315-0.804) as well as for OS (P = 0.002, HR = 0.371, 95% CI = 0.196-0.705).<h4>Conclusion</h4>Expression of IGKC has an independent protective impact on DFS and OS in node-negative breast cancer.
Addresses
  • Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany.
Autoren
  • Zonglin Chen
  • Aslihan Gerhold-Ay
  • Susanne Gebhard
  • Daniel Boehm
  • Christine Solbach
  • Antje Lebrecht
  • Marco Battista
  • Isabel Sicking
  • Christina Cotarelo
  • Cristina Cadenas
  • Rosemarie Marchan
  • Joanna D Stewart
  • Mathias Gehrmann
  • Heinz Koelbl
  • Jan G Hengstler
  • Marcus Schmidt
DOI
10.1371/journal.pone.0044741
eISSN
1932-6203
Externe Identifier
  • PubMed Identifier: 23028600
  • PubMed Central ID: PMC3461001
Open access
true
ISSN
1932-6203
Ausgabe der Veröffentlichung
9
Zeitschrift
PloS one
Schlüsselwörter
  • Humans
  • Breast Neoplasms
  • Disease-Free Survival
  • Immunohistochemistry
  • Middle Aged
  • Female
  • Immunoglobulin kappa-Chains
Sprache
eng
Medium
Print-Electronic
Online publication date
2012
Open access status
Open Access
Paginierung
e44741
Datum der Veröffentlichung
2012
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2012
Titel
Immunoglobulin kappa C predicts overall survival in node-negative breast cancer.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
7

Files

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044741&type=printable https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028600/pdf/?tool=EBI https://europepmc.org/articles/PMC3461001?pdf=render

Data source: Europe PubMed Central

Abstract
BACKGROUND: Biomarkers of the immune system are currently not used as prognostic factors in breast cancer. We analyzed the association of the B cell/plasma cell marker immunoglobulin kappa C (IGKC) and survival of untreated node-negative breast cancer patients. MATERIAL AND METHODS: IGKC expression was evaluated by immunostaining in a cohort of 335 node-negative breast cancer patients with a median follow-up of 152 months. The prognostic significance of IGKC for disease-free survival (DFS) and breast cancer-specific overall survival (OS) was evaluated with Kaplan-Meier survival analysis as well as univariate and multivariate Cox analysis adjusted for age at diagnosis, pT stage, histological grade, estrogen receptor (ER) status, progesterone receptor (PR) status, Ki-67 and human epidermal growth factor receptor 2 (HER-2) status. RESULTS: 160 patients (47.7%) showed strong expression of IGKC. Univariate analysis showed that IGKC was significantly associated with DFS (P = 0.017, hazard ratio [HR] = 0.570, 95% confidence interval [CI] = 0.360-0.903) and OS (P = 0.011, HR = 0.438, 95% CI = 0.233-0.822) in the entire cohort. The significance of IGKC was especially strong in ER negative and in luminal B carcinomas. In multivariate analysis IGKC retained its significance independent of established clinical factors for DFS (P = 0.004, HR = 0.504, 95% CI = 0.315-0.804) as well as for OS (P = 0.002, HR = 0.371, 95% CI = 0.196-0.705). CONCLUSION: Expression of IGKC has an independent protective impact on DFS and OS in node-negative breast cancer.
Date of acceptance
2012
Autoren
  • Zonglin Chen
  • Aslihan Gerhold-Ay
  • Susanne Gebhard
  • Daniel Boehm
  • Christine Solbach
  • Antje Lebrecht
  • Marco Battista
  • Isabel Sicking
  • Christina Cotarelo
  • Cristina Cadenas
  • Rosemarie Marchan
  • Joanna D Stewart
  • Mathias Gehrmann
  • Heinz Koelbl
  • Jan G Hengstler
  • Marcus Schmidt
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/23028600
DOI
10.1371/journal.pone.0044741
eISSN
1932-6203
Externe Identifier
  • PubMed Central ID: PMC3461001
Ausgabe der Veröffentlichung
9
Zeitschrift
PLoS One
Schlüsselwörter
  • Breast Neoplasms
  • Disease-Free Survival
  • Female
  • Humans
  • Immunoglobulin kappa-Chains
  • Immunohistochemistry
  • Middle Aged
Sprache
eng
Country
United States
Paginierung
e44741
PII
PONE-D-12-14058
Datum der Veröffentlichung
2012
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2013
Titel
Immunoglobulin kappa C predicts overall survival in node-negative breast cancer.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
7

Data source: PubMed

Author's licence
CC-BY
Autoren
  • Zonglin Chen
  • Aslihan Gerhold-Ay
  • Susanne Gebhard
  • Daniel Boehm
  • Christine Solbach
  • Antje Lebrecht
  • Marco Battista
  • Isabel Sicking
  • Christina Cotarelo
  • Cristina Cadenas
  • Rosemarie Marchan
  • Joanna D Stewart
  • Mathias Gehrmann
  • Heinz Koelbl
  • Jan G Hengstler
  • Marcus Schmidt
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-OA-Publizieren (2012 - 2017)
Resource version
Published version
DOI
10.1371/journal.pone.0044741
Funding acknowledgements
  • DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
File(s) embargoed
false
Open access
true
ISSN
1932-6203
Ausgabe der Veröffentlichung
9
Zeitschrift
PLoS one
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
e44741
Datum der Veröffentlichung
2012
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/7971
Herausgeber
PLoS
Herausgeber URL
http://dx.doi.org/10.1371/journal.pone.0044741
Datum der Datenerfassung
2022
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Zugang
Public
Titel
Immunoglobulin kappa C predicts overall survival in node-negative breast cancer
Ausgabe der Zeitschrift
7

Files

immunoglobulin_kappa_c_predic-20220925143615083.pdf

Data source: OPENSCIENCE.UB

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