Decelerated neurodegeneration after intravitreal injection of α-synuclein antibodies in a glaucoma animal model
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Julia Teister
- F Anders
- Sabine Beck
- S Funke
- H von Pein
- Verena Prokosch-Willing
- Norbert Pfeiffer
- Franz-Hermann Grus
- Sammlungen
- metadata
- ISSN
- 2045-2322
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Scientific reports
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Notes
- Prokosch-Willing, Verena veröffentlicht unter: Prokosch, Verena
- Paginierung
- Art. 6260
- Datum der Veröffentlichung
- 2017
- Herausgeber
- Macmillan Publishers Limited, part of Springer Nature
- Herausgeber URL
- http://dx.doi.org/10.1038/s41598-017-06702-1
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- Decelerated neurodegeneration after intravitreal injection of α-synuclein antibodies in a glaucoma animal model
- Ausgabe der Zeitschrift
- 7
Data source: METADATA.UB
- Other metadata sources:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Although elevated intraocular pressure (IOP) remains the major risk factor in glaucoma, neurodegenerative processes continue despite effective IOP lowering. Altered α-synuclein antibody (Abs) levels have been reported to play a crucial role. This study aimed at identifying whether α-synuclein Abs are capable to decelerate neuronal decay while providing insights into proteomic changes. Four groups of Sprague Dawley rats received episcleral vein occlusion: (1) CTRL, no intravitreal injection, n = 6, (2) CTRL IgG, intravitreal injection of unspecific IgG, n = 5, (3) Buffer, intravitreal injection of buffer, n = 6, (4), α-synuclein Ab, intravitreal injection of α-synuclein Ab, n = 5. IOP and retinal nerve fiber layer thickness (RNFLT) were monitored and immunohistochemistry, microarray and proteomic analysis were performed. RNFLT was reduced in CTRL, CTRL IgG and Buffer group (all p < 0.01) and α-synuclein Ab group (p = 0.17). Axon and RGC density showed an increased neurodegeneration in CTRL, CTRL IgG and Buffer group (all p < 0.01) and increased neuronal survival in α-synuclein Ab group (p = 0.38 and 0.06, respectively) compared with fellow eyes. Proteomic analysis revealed alterations of cofilin 1 and superoxide dismutase 1 expression. This data indicate that α-synuclein Ab might indirectly modulate the actin cytoskeleton organization and negatively regulate apoptotic processes via cofilin 1 and superoxide dismutase 1.</jats:p>
- Autoren
- J Teister
- F Anders
- S Beck
- S Funke
- H von Pein
- V Prokosch
- N Pfeiffer
- F Grus
- DOI
- 10.1038/s41598-017-06702-1
- eISSN
- 2045-2322
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Scientific Reports
- Sprache
- en
- Artikelnummer
- 6260
- Online publication date
- 2017
- Status
- Published online
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/s41598-017-06702-1
- Datum der Datenerfassung
- 2022
- Titel
- Decelerated neurodegeneration after intravitreal injection of α-synuclein antibodies in a glaucoma animal model
- Ausgabe der Zeitschrift
- 7
Data source: Crossref
- Author's licence
- CC-BY
- Autoren
- Julia Teister
- F Anders
- Sabine Beck
- S Funke
- H von Pein
- Verena Prokosch-Willing
- Norbert Pfeiffer
- Franz-Hermann Grus
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- DFG-OA-Publizieren (2012 - 2017)
- Resource version
- Published version
- DOI
- 10.1038/s41598-017-06702-1
- Funding acknowledgements
- DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 2045-2322
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Scientific reports
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Notes
- Prokosch-Willing, Verena veröffentlicht unter: Prokosch, Verena
- Open access status
- Open Access
- Paginierung
- Art. 6260
- Datum der Veröffentlichung
- 2017
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/7592
- Herausgeber
- Macmillan Publishers Limited, part of Springer Nature
- Herausgeber URL
- http://dx.doi.org/10.1038/s41598-017-06702-1
- Datum der Datenerfassung
- 2022
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Zugang
- Public
- Titel
- Decelerated neurodegeneration after intravitreal injection of α-synuclein antibodies in a glaucoma animal model
- Ausgabe der Zeitschrift
- 7
Files
decelerated_neurodegeneration-20220817163444959.pdf
Data source: OPENSCIENCE.UB