Molecular biology of cantharidin in cancer cells
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Rolf Rauh
- Stefan Kahl
- Herbert Boechzelt
- Rudolf Bauer
- Bernd Kaina
- Thomas Efferth
- Sammlungen
- metadata
- Zeitschrift
- Chinese medicine
- Schlüsselwörter
- 570 Biowissenschaften
- 570 Life sciences
- Sprache
- eng
- Paginierung
- 8
- Datum der Veröffentlichung
- 2007
- Herausgeber
- BioMed Central
- Herausgeber URL
- http://dx.doi.org/10.1186/1749-8546-2-8
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- Molecular biology of cantharidin in cancer cells
- Ausgabe der Zeitschrift
- 2
Data source: METADATA.UB
- Other metadata sources:
-
- Abstract
- <jats:title>Abstract</jats:title> <jats:p>Herbal medicine is one of the forms of traditional medical practice. Traditional Chinese medicine (TCM) and traditional Vietnamese medicine (TVM) are well-known for their long-standing tradition of herbal medicine.</jats:p> <jats:p>Secreted by many species of blister beetle, most notably by the 'Spanish fly' (<jats:italic>Lytta vesicatoria</jats:italic>), cantharidin inhibits protein phosphatases 1 and 2A (PP1, PP2A). Blister beetle has been used in Asian traditional medicine to treat <jats:italic>Molluscum contagiosum</jats:italic> virus (MCV) infections and associated warts, and is now also used for cancer treatment. A combination of both genomic and postgenomic techniques was used in our studies to identify candidate genes affecting sensitivity or resistance to cantharidin. Cantharidin was not found to be related to multidrug resistance phenotype, suggesting its potential usefulness for the treatment of refractory tumors. Oxidative stress response genes diminish the activity of cantharidin by inducing DNA strand breaks which may be subject to base excision repair and induce apoptosis in a p53- and Bcl2-dependent manner.</jats:p> <jats:p>Cantharidin is one of many natural products used in traditional Chinese medicine and traditional Vietnamese medicine for cancer treatment. Combined methods of pharmaceutical biology and molecular biology can help elucidate modes of action of these natural products.</jats:p>
- Autoren
- Rolf Rauh
- Stefan Kahl
- Herbert Boechzelt
- Rudolf Bauer
- Bernd Kaina
- Thomas Efferth
- DOI
- 10.1186/1749-8546-2-8
- eISSN
- 1749-8546
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Chinese Medicine
- Sprache
- en
- Artikelnummer
- 8
- Online publication date
- 2007
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1186/1749-8546-2-8
- Datum der Datenerfassung
- 2021
- Titel
- Molecular biology of cantharidin in cancer cells
- Ausgabe der Zeitschrift
- 2
Data source: Crossref
- Abstract
- Herbal medicine is one of the forms of traditional medical practice. Traditional Chinese medicine (TCM) and traditional Vietnamese medicine (TVM) are well-known for their long-standing tradition of herbal medicine. Secreted by many species of blister beetle, most notably by the 'Spanish fly' (Lytta vesicatoria), cantharidin inhibits protein phosphatases 1 and 2A (PP1, PP2A). Blister beetle has been used in Asian traditional medicine to treat Molluscum contagiosum virus (MCV) infections and associated warts, and is now also used for cancer treatment. A combination of both genomic and postgenomic techniques was used in our studies to identify candidate genes affecting sensitivity or resistance to cantharidin. Cantharidin was not found to be related to multidrug resistance phenotype, suggesting its potential usefulness for the treatment of refractory tumors. Oxidative stress response genes diminish the activity of cantharidin by inducing DNA strand breaks which may be subject to base excision repair and induce apoptosis in a p53- and Bcl2-dependent manner. Cantharidin is one of many natural products used in traditional Chinese medicine and traditional Vietnamese medicine for cancer treatment. Combined methods of pharmaceutical biology and molecular biology can help elucidate modes of action of these natural products.
- Addresses
- State of Maryland Department of Health and Mental Hygiene, Maryland, USA. rolfrauh@comcast.net
- Autoren
- Rolf Rauh
- Stefan Kahl
- Herbert Boechzelt
- Rudolf Bauer
- Bernd Kaina
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1186/1749-8546-2-8
- eISSN
- 1749-8546
- Externe Identifier
- PubMed Identifier: 17610718
- PubMed Central ID: PMC1934358
- Open access
- true
- ISSN
- 1749-8546
- Zeitschrift
- Chinese medicine
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2007
- Open access status
- Open Access
- Paginierung
- 8
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2007
- Titel
- Molecular biology of cantharidin in cancer cells.
- Sub types
- review-article
- Journal Article
- Ausgabe der Zeitschrift
- 2
Files
https://cmjournal.biomedcentral.com/track/pdf/10.1186/1749-8546-2-8 https://europepmc.org/articles/PMC1934358?pdf=render
Data source: Europe PubMed Central
- Abstract
- Herbal medicine is one of the forms of traditional medical practice. Traditional Chinese medicine (TCM) and traditional Vietnamese medicine (TVM) are well-known for their long-standing tradition of herbal medicine. Secreted by many species of blister beetle, most notably by the 'Spanish fly' (Lytta vesicatoria), cantharidin inhibits protein phosphatases 1 and 2A (PP1, PP2A). Blister beetle has been used in Asian traditional medicine to treat Molluscum contagiosum virus (MCV) infections and associated warts, and is now also used for cancer treatment. A combination of both genomic and postgenomic techniques was used in our studies to identify candidate genes affecting sensitivity or resistance to cantharidin. Cantharidin was not found to be related to multidrug resistance phenotype, suggesting its potential usefulness for the treatment of refractory tumors. Oxidative stress response genes diminish the activity of cantharidin by inducing DNA strand breaks which may be subject to base excision repair and induce apoptosis in a p53- and Bcl2-dependent manner. Cantharidin is one of many natural products used in traditional Chinese medicine and traditional Vietnamese medicine for cancer treatment. Combined methods of pharmaceutical biology and molecular biology can help elucidate modes of action of these natural products.
- Date of acceptance
- 2007
- Autoren
- Rolf Rauh
- Stefan Kahl
- Herbert Boechzelt
- Rudolf Bauer
- Bernd Kaina
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/17610718
- DOI
- 10.1186/1749-8546-2-8
- eISSN
- 1749-8546
- Externe Identifier
- PubMed Central ID: PMC1934358
- Zeitschrift
- Chin Med
- Sprache
- eng
- Country
- England
- Paginierung
- 8
- PII
- 1749-8546-2-8
- Datum der Veröffentlichung
- 2007
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2007
- Titel
- Molecular biology of cantharidin in cancer cells.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 2
Data source: PubMed
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