Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, Guieranone A
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Victor Kuete
- Tolga Eichhorn
- Benjamin Wiench
- Benjamin Krusche
- Thomas Efferth
- Sammlungen
- metadata
- ISSN
- 1747-1028
- Zeitschrift
- Cell division
- Schlüsselwörter
- 570 Biowissenschaften
- 570 Life sciences
- Sprache
- eng
- Paginierung
- 16
- Datum der Veröffentlichung
- 2012
- Herausgeber
- BioMed Central
- Herausgeber URL
- http://dx.doi.org/10.1186/1747-1028-7-16
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, Guieranone A
- Ausgabe der Zeitschrift
- 7
Data source: METADATA.UB
- Other metadata sources:
-
- Autoren
- Victor Kuete
- Tolga Eichhorn
- Benjamin Wiench
- Benjamin Krusche
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000309207400001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1186/1747-1028-7-16
- eISSN
- 1747-1028
- Externe Identifier
- Clarivate Analytics Document Solution ID: 012AJ
- PubMed Identifier: 22892065
- Zeitschrift
- CELL DIVISION
- Schlüsselwörter
- Angiogensis
- Apoptosis
- Cytotoxicity
- Guieranone A
- Microarray
- Pharmacogenomics
- Artikelnummer
- ARTN 16
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A
- Sub types
- Article
- Ausgabe der Zeitschrift
- 7
Data source: Web of Science (Lite)
- Autoren
- Victor Kuete
- Tolga Eichhorn
- Benjamin Wiench
- Benjamin Krusche
- Thomas Efferth
- DOI
- 10.1186/1747-1028-7-16
- ISSN
- 1747-1028
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Cell Division
- Sprache
- en
- Paginierung
- 16 - 16
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1186/1747-1028-7-16
- Datum der Datenerfassung
- 2016
- Titel
- Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A
- Ausgabe der Zeitschrift
- 7
Data source: Crossref
- Abstract
- <h4>Background</h4>Malignant diseases are responsible of approximately 13% of all deaths each year in the world. Natural products represent a valuable source for the development of novel anticancer drugs. The present study was aimed at evaluating the cytotoxicity of a naphtyl butanone isolated from the leaves of Guiera senegalensis, guieranone A (GA).<h4>Results</h4>The results indicated that GA was active on 91.67% of the 12 tested cancer cell lines, the IC50 values below 4 μg/ml being recorded on 83.33% of them. In addition, the IC50 values obtained on human lymphoblastic leukemia CCRF-CEM (0.73 μg/ml) and its resistant subline CEM/ADR5000 (1.01 μg/ml) and on lung adenocarcinoma A549 (0.72 μg/ml) cell lines were closer or lower than that of doxorubicin. Interestingly, low cytotoxicity to normal hepatocyte, AML12 cell line was observed. GA showed anti-angiogenic activity with up to 51.9% inhibition of the growth of blood capillaries on the chorioallantoic membrane of quail embryo. Its also induced apotosis and cell cycle arrest. Ingenuity Pathway Analysis identified several pathways in CCRF-CEM cells and functional group of genes regulated upon GA treatment (P < 0.05), the Cell Cycle: G2/M DNA Damage Checkpoint Regulation and ATM Signaling pathways being amongst the four most involved functional groups.<h4>Conclusion</h4>The overall results of this work provide evidence of the cytotoxic potential of GA and supportive data for its possible use in cancer chemotherapy.
- Addresses
- Department of Biochemistry, Faculty of science, University of Dschang, Dschang, Cameroon. kuetevictor@yahoo.fr.
- Autoren
- Victor Kuete
- Tolga Eichhorn
- Benjamin Wiench
- Benjamin Krusche
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1186/1747-1028-7-16
- eISSN
- 1747-1028
- Externe Identifier
- PubMed Identifier: 22892065
- PubMed Central ID: PMC3782753
- Open access
- true
- ISSN
- 1747-1028
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Cell division
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2012
- Open access status
- Open Access
- Paginierung
- 16
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2012
- Titel
- Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 7
Files
https://celldiv.biomedcentral.com/counter/pdf/10.1186/1747-1028-7-16 https://europepmc.org/articles/PMC3782753?pdf=render
Data source: Europe PubMed Central
- Abstract
- BACKGROUND: Malignant diseases are responsible of approximately 13% of all deaths each year in the world. Natural products represent a valuable source for the development of novel anticancer drugs. The present study was aimed at evaluating the cytotoxicity of a naphtyl butanone isolated from the leaves of Guiera senegalensis, guieranone A (GA). RESULTS: The results indicated that GA was active on 91.67% of the 12 tested cancer cell lines, the IC50 values below 4 μg/ml being recorded on 83.33% of them. In addition, the IC50 values obtained on human lymphoblastic leukemia CCRF-CEM (0.73 μg/ml) and its resistant subline CEM/ADR5000 (1.01 μg/ml) and on lung adenocarcinoma A549 (0.72 μg/ml) cell lines were closer or lower than that of doxorubicin. Interestingly, low cytotoxicity to normal hepatocyte, AML12 cell line was observed. GA showed anti-angiogenic activity with up to 51.9% inhibition of the growth of blood capillaries on the chorioallantoic membrane of quail embryo. Its also induced apotosis and cell cycle arrest. Ingenuity Pathway Analysis identified several pathways in CCRF-CEM cells and functional group of genes regulated upon GA treatment (P < 0.05), the Cell Cycle: G2/M DNA Damage Checkpoint Regulation and ATM Signaling pathways being amongst the four most involved functional groups. CONCLUSION: The overall results of this work provide evidence of the cytotoxic potential of GA and supportive data for its possible use in cancer chemotherapy.
- Date of acceptance
- 2012
- Autoren
- Victor Kuete
- Tolga Eichhorn
- Benjamin Wiench
- Benjamin Krusche
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/22892065
- DOI
- 10.1186/1747-1028-7-16
- eISSN
- 1747-1028
- Externe Identifier
- PubMed Central ID: PMC3782753
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Cell Div
- Sprache
- eng
- Country
- England
- Paginierung
- 16
- PII
- 1747-1028-7-16
- Datum der Veröffentlichung
- 2012
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 7
Data source: PubMed
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