Testes-specific hemoglobins in drosophila evolved by a combination of sub- and neofunctionalization after gene duplication
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Eva Gleixner
- Holger Herlyn
- Stefan Zimmerling
- Thorsten Burmester
- Thomas Hankeln
- Sammlungen
- metadata
- ISSN
- 1471-2148
- Zeitschrift
- Bmc evolutionary biology
- Schlüsselwörter
- 570 Biowissenschaften
- 570 Life sciences
- Sprache
- eng
- Paginierung
- Art. 34
- Datum der Veröffentlichung
- 2012
- Herausgeber
- Biomed Central Ltd
- Herausgeber URL
- http://dx.doi.org/10.1186/1471-2148-12-34
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- Testes-specific hemoglobins in drosophila evolved by a combination of sub- and neofunctionalization after gene duplication
- Ausgabe der Zeitschrift
- 12
Data source: METADATA.UB
- Other metadata sources:
-
- Abstract
- <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>For a long time the presence of respiratory proteins in most insects has been considered unnecessary. However, in recent years it has become evident that globins belong to the standard repertoire of the insect genome. Like most other insect globins, the <jats:italic>glob1</jats:italic> gene of <jats:italic>Drosophila melanogaster</jats:italic> displays a conserved expression pattern in the tracheae, the fat body and the Malpighian tubules.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Here we show that the recently discovered <jats:italic>D. melanogaster</jats:italic> globin genes <jats:italic>glob2</jats:italic> and <jats:italic>glob3</jats:italic> both display an unusual male-specific expression in the reproductive tract during spermatogenesis. Both paralogs are transcribed at equivalent mRNA levels and largely overlap in their cellular expression patterns during spermatogenesis. Phylogenetic analyses showed that <jats:italic>glob2</jats:italic> and <jats:italic>glob3</jats:italic> reflect a gene duplication event that occurred in the ancestor of the <jats:italic>Sophophora</jats:italic> subgenus at least 40 million years ago. Therefore, flies of the <jats:italic>Drosophila</jats:italic> subgenus harbor only one <jats:italic>glob2/3</jats:italic>-like gene.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Phylogenetic and sequence analyses indicate an evolution of the <jats:italic>glob2</jats:italic> and <jats:italic>glob3</jats:italic> duplicates by a combination of sub- and neofunctionalization. Considering their restricted, testes-specific expression, an involvement of both globins in alleviating oxidative stress during spermatogenesis is conceivable.</jats:p> </jats:sec>
- Autoren
- Eva Gleixner
- Holger Herlyn
- Stefan Zimmerling
- Thorsten Burmester
- Thomas Hankeln
- DOI
- 10.1186/1471-2148-12-34
- eISSN
- 1471-2148
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- BMC Evolutionary Biology
- Sprache
- en
- Artikelnummer
- 34
- Online publication date
- 2012
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1186/1471-2148-12-34
- Datum der Datenerfassung
- 2021
- Titel
- Testes-specific hemoglobins in Drosophilaevolved by a combination of sub- and neofunctionalization after gene duplication
- Ausgabe der Zeitschrift
- 12
Data source: Crossref
- Author's licence
- CC-BY
- Autoren
- Eva Gleixner
- Holger Herlyn
- Stefan Zimmerling
- Thorsten Burmester
- Thomas Hankeln
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- DFG-OA-Publizieren (2012 - 2017)
- Resource version
- Published version
- DOI
- 10.1186/1471-2148-12-34
- Funding acknowledgements
- DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 1471-2148
- Zeitschrift
- Bmc evolutionary biology
- Schlüsselwörter
- 570 Biowissenschaften
- 570 Life sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- Art. 34
- Datum der Veröffentlichung
- 2012
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/7163
- Herausgeber
- Biomed Central Ltd
- Herausgeber URL
- http://dx.doi.org/10.1186/1471-2148-12-34
- Datum der Datenerfassung
- 2022
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Zugang
- Public
- Titel
- Testes-specific hemoglobins in drosophila evolved by a combination of sub- and neofunctionalization after gene duplication
- Ausgabe der Zeitschrift
- 12
Files
testesspecific_hemoglobins_in-20220612162942177.pdf
Data source: OPENSCIENCE.UB