Pentaerythritol tetranitrate in vivo treatment improves oxidative stress and vascular disfunction by supression of endothelin-1 signaling in monocrotaline-induced pulmonary hypertension
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Sebastian Steven
- Matthias Oelze
- Moritz Brandt
- Elisabeth Ullmann
- Swenja Kröller-Schön
- Tjebo Heeren
- Lan P Tran
- Steffen Daub
- Mobin Dib
- Dirk Stalleicken
- Philip Wenzel
- Thomas Münzel
- Andreas Daiber
- Sammlungen
- metadata
- ISSN
- 1942-0994
- Zeitschrift
- Oxidative medicine and cellular longevity
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Paginierung
- Art. 4353462
- Datum der Veröffentlichung
- 2017
- Herausgeber
- Landes Bioscience
- Herausgeber URL
- http://dx.doi.org/10.1155/2017/4353462
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- Pentaerythritol tetranitrate in vivo treatment improves oxidative stress and vascular disfunction by supression of endothelin-1 signaling in monocrotaline-induced pulmonary hypertension
- Ausgabe der Zeitschrift
- 2017
Data source: METADATA.UB
- Other metadata sources:
-
- Abstract
- <jats:p><jats:italic>Objective</jats:italic>. Oxidative stress and endothelial dysfunction contribute to pulmonary arterial hypertension (PAH). The role of the nitrovasodilator pentaerythritol tetranitrate (PETN) on endothelial function and oxidative stress in PAH has not yet been defined.<jats:italic>Methods and Results</jats:italic>. PAH was induced by monocrotaline (MCT, i.v.) in Wistar rats. Low (30 mg/kg; MCT30), middle (40 mg/kg; MCT40), or high (60 mg/kg; MCT60) dose of MCT for 14, 28, and 42 d was used. MCT induced endothelial dysfunction, pulmonary vascular wall thickening, and fibrosis, as well as protein tyrosine nitration. Pulmonary arterial pressure and heart/body and lung/body weight ratio were increased in MCT40 rats (28 d) and reduced by oral PETN (10 mg/kg, 24 d) therapy. Oxidative stress in the vascular wall, in the heart, and in whole blood as well as vascular endothelin-1 signaling was increased in MCT40-treated rats and normalized by PETN therapy, likely by upregulation of heme oxygenase-1 (HO-1). PETN therapy improved endothelium-dependent relaxation in pulmonary arteries and inhibited endothelin-1-induced oxidative burst in whole blood and the expression of adhesion molecule (ICAM-1) in endothelial cells.<jats:italic>Conclusion</jats:italic>. MCT-induced PAH impairs endothelial function (aorta and pulmonary arteries) and increases oxidative stress whereas PETN markedly attenuates these adverse effects. Thus, PETN therapy improves pulmonary hypertension beyond its known cardiac preload reducing ability.</jats:p>
- Autoren
- Sebastian Steven
- Matthias Oelze
- Moritz Brandt
- Elisabeth Ullmann
- Swenja Kröller-Schön
- Tjebo Heeren
- Lan P Tran
- Steffen Daub
- Mobin Dib
- Dirk Stalleicken
- Philip Wenzel
- Thomas Münzel
- Andreas Daiber
- DOI
- 10.1155/2017/4353462
- eISSN
- 1942-0994
- ISSN
- 1942-0900
- Zeitschrift
- Oxidative Medicine and Cellular Longevity
- Sprache
- en
- Paginierung
- 1 - 13
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Herausgeber
- Hindawi Limited
- Herausgeber URL
- http://dx.doi.org/10.1155/2017/4353462
- Datum der Datenerfassung
- 2017
- Titel
- Pentaerythritol Tetranitrate In Vivo Treatment Improves Oxidative Stress and Vascular Dysfunction by Suppression of Endothelin-1 Signaling in Monocrotaline-Induced Pulmonary Hypertension
- Ausgabe der Zeitschrift
- 2017
Data source: Crossref
- Author's licence
- CC-BY
- Autoren
- Sebastian Steven
- Matthias Oelze
- Moritz Brandt
- Elisabeth Ullmann
- Swenja Kröller-Schön
- Tjebo Heeren
- Lan P Tran
- Steffen Daub
- Mobin Dib
- Dirk Stalleicken
- Philip Wenzel
- Thomas Münzel
- Andreas Daiber
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- DFG-OA-Publizieren (2012 - 2017)
- Resource version
- Published version
- DOI
- 10.1155/2017/4353462
- Funding acknowledgements
- DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 1942-0994
- Zeitschrift
- Oxidative medicine and cellular longevity
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- Art. 4353462
- Datum der Veröffentlichung
- 2017
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/7921
- Herausgeber
- Landes Bioscience
- Herausgeber URL
- http://dx.doi.org/10.1155/2017/4353462
- Datum der Datenerfassung
- 2022
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Zugang
- Public
- Titel
- Pentaerythritol tetranitrate in vivo treatment improves oxidative stress and vascular disfunction by supression of endothelin-1 signaling in monocrotaline-induced pulmonary hypertension
- Ausgabe der Zeitschrift
- 2017
Files
pentaerythritol_tetranitrate_-20221007113503071.pdf
Data source: OPENSCIENCE.UB