Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Victor Kuete
- Hippolyte K Wabo
- Kenneth O Eyong
- Michel T Feussi
- Benjamin Wiench
- Benjamin Krusche
- Pierre Tane
- Gabriel N Folefoc
- Thomas Efferth
- Sammlungen
- metadata
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- PLoS one
- Schlüsselwörter
- 570 Biowissenschaften
- 570 Life sciences
- Sprache
- eng
- Paginierung
- e21762
- Datum der Veröffentlichung
- 2011
- Herausgeber
- PLoS
- Herausgeber URL
- http://dx.doi.org/10.1371/journal.pone.0021762
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants
- Ausgabe der Zeitschrift
- 6
Data source: METADATA.UB
- Other metadata sources:
-
- Autoren
- Victor Kuete
- Hippolyte K Wabo
- Kenneth O Eyong
- Michel T Feussi
- Benjamin Wiench
- Benjamin Krusche
- Pierre Tane
- Gabriel N Folefoc
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000294128100001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1371/journal.pone.0021762
- Externe Identifier
- Clarivate Analytics Document Solution ID: 810LZ
- PubMed Identifier: 21886765
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- PLOS ONE
- Artikelnummer
- ARTN e21762
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Titel
- Anticancer Activities of Six Selected Natural Compounds of Some Cameroonian Medicinal Plants
- Sub types
- Article
- Ausgabe der Zeitschrift
- 6
Data source: Web of Science (Lite)
- Autoren
- Victor Kuete
- Hippolyte K Wabo
- Kenneth O Eyong
- Michel T Feussi
- Benjamin Wiench
- Benjamin Krusche
- Pierre Tane
- Gabriel N Folefoc
- Thomas Efferth
- DOI
- 10.1371/journal.pone.0021762
- Editoren
- Maria A Deli
- eISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- PLoS ONE
- Sprache
- en
- Online publication date
- 2011
- Paginierung
- e21762 - e21762
- Status
- Published online
- Herausgeber
- Public Library of Science (PLoS)
- Herausgeber URL
- http://dx.doi.org/10.1371/journal.pone.0021762
- Datum der Datenerfassung
- 2018
- Titel
- Anticancer Activities of Six Selected Natural Compounds of Some Cameroonian Medicinal Plants
- Ausgabe der Zeitschrift
- 6
Data source: Crossref
- Abstract
- <h4>Background</h4>Natural products are well recognized as sources of drugs in several human ailments. In the present work, we carried out a preliminary screening of six natural compounds, xanthone V(1) (1); 2-acetylfuro-1,4-naphthoquinone (2); physcion (3); bisvismiaquinone (4); vismiaquinone (5); 1,8-dihydroxy-3-geranyloxy-6-methylanthraquinone (6) against MiaPaCa-2 pancreatic and CCRF-CEM leukemia cells and their multidrug-resistant subline, CEM/ADR5000. Compounds 1 and 2 were then tested in several other cancer cells and their possible mode of action were investigated.<h4>Methodology/findings</h4>The tested compounds were previously isolated from the Cameroonian medicinal plants Vismia laurentii (1, 3, 4, 5 and 6) and Newbouldia laevis (2). The preliminary cytotoxicity results allowed the selection of xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone, which were then tested on a panel of cancer cell lines. The study was also extended to the analysis of cell cycle distribution, apoptosis induction, caspase 3/7 activation and the anti-angiogenic properties of xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone. IC(50) values around or below 4 µg/ml were obtained on 64.29% and 78.57% of the tested cancer cell lines for xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone, respectively. The most sensitive cell lines (IC(50)<1 µg/ml) were breast MCF-7 (to xanthone V(1)), cervix HeLa and Caski (to xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone), leukemia PF-382 and melanoma colo-38 (to 2-acetylfuro-1,4-naphthoquinone). The two compounds showed respectively, 65.8% and 59.6% inhibition of the growth of blood capillaries on the chorioallantoic membrane of quail eggs in the anti-angiogenic assay. Upon treatment with two fold IC(50) and after 72 h, the two compounds induced cell cycle arrest in S-phase, and also significant apoptosis in CCRF-CEM leukemia cells. Caspase 3/7 was activated by xanthone V(1).<h4>Conclusions/significance</h4>The overall results of the present study provided evidence for the cytotoxicity of compounds xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone, and bring supportive data for future investigations that will lead to their use in cancer therapy.
- Addresses
- Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
- Autoren
- Victor Kuete
- Hippolyte K Wabo
- Kenneth O Eyong
- Michel T Feussi
- Benjamin Wiench
- Benjamin Krusche
- Pierre Tane
- Gabriel N Folefoc
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1371/journal.pone.0021762
- eISSN
- 1932-6203
- Externe Identifier
- PubMed Identifier: 21886765
- PubMed Central ID: PMC3158745
- Open access
- true
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- PloS one
- Schlüsselwörter
- Capillaries
- Cell Line, Tumor
- Animals
- Quail
- Humans
- Plants, Medicinal
- Doxorubicin
- Antineoplastic Agents
- Biological Products
- Cell Cycle
- Cell Death
- Cell Proliferation
- Cameroon
- Caspase 3
- Caspase 7
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2011
- Open access status
- Open Access
- Paginierung
- e21762
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2011
- Titel
- Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 6
Files
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021762&type=printable https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21886765/pdf/?tool=EBI https://europepmc.org/articles/PMC3158745?pdf=render
Data source: Europe PubMed Central
- Abstract
- BACKGROUND: Natural products are well recognized as sources of drugs in several human ailments. In the present work, we carried out a preliminary screening of six natural compounds, xanthone V(1) (1); 2-acetylfuro-1,4-naphthoquinone (2); physcion (3); bisvismiaquinone (4); vismiaquinone (5); 1,8-dihydroxy-3-geranyloxy-6-methylanthraquinone (6) against MiaPaCa-2 pancreatic and CCRF-CEM leukemia cells and their multidrug-resistant subline, CEM/ADR5000. Compounds 1 and 2 were then tested in several other cancer cells and their possible mode of action were investigated. METHODOLOGY/FINDINGS: The tested compounds were previously isolated from the Cameroonian medicinal plants Vismia laurentii (1, 3, 4, 5 and 6) and Newbouldia laevis (2). The preliminary cytotoxicity results allowed the selection of xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone, which were then tested on a panel of cancer cell lines. The study was also extended to the analysis of cell cycle distribution, apoptosis induction, caspase 3/7 activation and the anti-angiogenic properties of xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone. IC(50) values around or below 4 µg/ml were obtained on 64.29% and 78.57% of the tested cancer cell lines for xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone, respectively. The most sensitive cell lines (IC(50)<1 µg/ml) were breast MCF-7 (to xanthone V(1)), cervix HeLa and Caski (to xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone), leukemia PF-382 and melanoma colo-38 (to 2-acetylfuro-1,4-naphthoquinone). The two compounds showed respectively, 65.8% and 59.6% inhibition of the growth of blood capillaries on the chorioallantoic membrane of quail eggs in the anti-angiogenic assay. Upon treatment with two fold IC(50) and after 72 h, the two compounds induced cell cycle arrest in S-phase, and also significant apoptosis in CCRF-CEM leukemia cells. Caspase 3/7 was activated by xanthone V(1). CONCLUSIONS/SIGNIFICANCE: The overall results of the present study provided evidence for the cytotoxicity of compounds xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone, and bring supportive data for future investigations that will lead to their use in cancer therapy.
- Date of acceptance
- 2011
- Autoren
- Victor Kuete
- Hippolyte K Wabo
- Kenneth O Eyong
- Michel T Feussi
- Benjamin Wiench
- Benjamin Krusche
- Pierre Tane
- Gabriel N Folefoc
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/21886765
- DOI
- 10.1371/journal.pone.0021762
- eISSN
- 1932-6203
- Externe Identifier
- PubMed Central ID: PMC3158745
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- PLoS One
- Schlüsselwörter
- Animals
- Antineoplastic Agents
- Biological Products
- Cameroon
- Capillaries
- Caspase 3
- Caspase 7
- Cell Cycle
- Cell Death
- Cell Line, Tumor
- Cell Proliferation
- Doxorubicin
- Humans
- Plants, Medicinal
- Quail
- Sprache
- eng
- Country
- United States
- Paginierung
- e21762
- PII
- PONE-D-11-05322
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 6
Data source: PubMed
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