Activation of PI3K is associated with reduced survival in renal cell carcinoma

Publication type:
Journal article
Metadata:
Autoren
  • Axel S Merseburger
  • Joerg Hennenlotter
  • Ursula Kuehs
  • Perikles Simon
  • Stephan Kruck
  • Eva Koch
  • Arnulf Stenzl
  • Markus A Kuczyk
Sammlungen
  • metadata
ISSN
0042-1138
Ausgabe der Veröffentlichung
4
Zeitschrift
Urologia internationalis
Schlüsselwörter
  • 796 Sport
  • 796 Athletic and outdoor sports and games
Sprache
eng
Paginierung
Seiten: 372 - 377
Datum der Veröffentlichung
2008
Herausgeber URL
http://dx.doi.org/10.1159/000132694
Datum der Datenerfassung
2020
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Zugang
Public
Titel
Activation of PI3K is associated with reduced survival in renal cell carcinoma
Ausgabe der Zeitschrift
80

Data source: METADATA.UB

Other metadata sources:
Autoren
  • Axel S Merseburger
  • Joerg Hennenlotter
  • Ursula Kuehs
  • Perikles Simon
  • Stephan Kruck
  • Eva Koch
  • Arnulf Stenzl
  • Markus A Kuczyk
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000257459400005&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1159/000132694
eISSN
1423-0399
Externe Identifier
  • Clarivate Analytics Document Solution ID: 323PM
  • PubMed Identifier: 18587247
ISSN
0042-1138
Ausgabe der Veröffentlichung
4
Zeitschrift
UROLOGIA INTERNATIONALIS
Schlüsselwörter
  • renal cell carcinoma
  • phosphor Akt
  • phosphatase and tensin homolog
  • phosphatidylinositol 3-kinase
Paginierung
372 - 377
Datum der Veröffentlichung
2008
Status
Published
Titel
Activation of PI3K is associated with reduced survival in renal cell carcinoma
Sub types
  • Article
Ausgabe der Zeitschrift
80

Data source: Web of Science (Lite)

Abstract
<jats:p>&lt;i&gt;Objectives:&lt;/i&gt; The epidermal growth factor receptor- (EGFR) activated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt) pathway is associated with tumorigenesis and progression. The aims of the present study were to determine the expression patterns of Akt pathway parameters PI3K, phosphatase and tensin homolog (PTEN), phosphor-Akt (p-Akt) and their combination, for their possible prognostic value in renal cell carcinoma (RCC). PTEN dephosphorylates the liquid product of PI3K. &lt;i&gt;Methods:&lt;/i&gt; Tumor samples from 176 RCC patients were investigated for PTEN, p-Akt and PI3K expression by immunohistochemistry. Expression levels were correlated to clinical variables and postoperative outcome by uni- and multivariate statistical analysis. &lt;i&gt;Results:&lt;/i&gt; The various expression levels within the tumor samples were independent of histological grade and tumor stage, due to different levels of activation of the PI3K/p-Akt pathway. The activation of PI3K protein was found to be significantly associated with reduced survival times (p = 0.0304, multivariate analysis). Analysis of combined biomarker expressions showed that decreased long-term survival was correlated with PTEN low/p-Akt high expression (p &lt; 0.05). &lt;i&gt;Conclusions:&lt;/i&gt; Activation of the PI3K pathway is significantly associated with adverse clinical outcome in RCC. Analysis of biomarker combinations might identify high-risk patients and a subsequent need to adapt treatment modalities. Molecular pathways regulating PI3K activation appear to be promising targets for drug development in the clinical management of RCC patients.</jats:p>
Autoren
  • Axel S Merseburger
  • Joerg Hennenlotter
  • Ursula Kuehs
  • Perikles Simon
  • Stephan Kruck
  • Eva Koch
  • Arnulf Stenzl
  • Markus A Kuczyk
DOI
10.1159/000132694
eISSN
1423-0399
ISSN
0042-1138
Ausgabe der Veröffentlichung
4
Zeitschrift
Urologia Internationalis
Sprache
en
Online publication date
2008
Paginierung
372 - 377
Datum der Veröffentlichung
2008
Status
Published
Herausgeber
S. Karger AG
Herausgeber URL
http://dx.doi.org/10.1159/000132694
Datum der Datenerfassung
2024
Titel
Activation of PI3K Is Associated with Reduced Survival in Renal Cell Carcinoma
Ausgabe der Zeitschrift
80

Data source: Crossref

Abstract
<h4>Objectives</h4>The epidermal growth factor receptor- (EGFR) activated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt) pathway is associated with tumorigenesis and progression. The aims of the present study were to determine the expression patterns of Akt pathway parameters PI3K, phosphatase and tensin homolog (PTEN), phosphor-Akt (p-Akt) and their combination, for their possible prognostic value in renal cell carcinoma (RCC). PTEN dephosphorylates the liquid product of PI3K.<h4>Methods</h4>Tumor samples from 176 RCC patients were investigated for PTEN, p-Akt and PI3K expression by immunohistochemistry. Expression levels were correlated to clinical variables and postoperative outcome by uni- and multivariate statistical analysis.<h4>Results</h4>The various expression levels within the tumor samples were independent of histological grade and tumor stage, due to different levels of activation of the PI3K/p-Akt pathway. The activation of PI3K protein was found to be significantly associated with reduced survival times (p = 0.0304, multivariate analysis). Analysis of combined biomarker expressions showed that decreased long-term survival was correlated with PTEN low/p-Akt high expression (p < 0.05).<h4>Conclusions</h4>Activation of the PI3K pathway is significantly associated with adverse clinical outcome in RCC. Analysis of biomarker combinations might identify high-risk patients and a subsequent need to adapt treatment modalities. Molecular pathways regulating PI3K activation appear to be promising targets for drug development in the clinical management of RCC patients.
Addresses
  • Department of Urology, Eberhard Karls University Tübingen, Tübingen, Germany.
Autoren
  • Axel S Merseburger
  • Joerg Hennenlotter
  • Ursula Kuehs
  • Perikles Simon
  • Stephan Kruck
  • Eva Koch
  • Arnulf Stenzl
  • Markus A Kuczyk
DOI
10.1159/000132694
eISSN
1423-0399
Externe Identifier
  • PubMed Identifier: 18587247
Open access
false
ISSN
0042-1138
Ausgabe der Veröffentlichung
4
Zeitschrift
Urologia internationalis
Schlüsselwörter
  • Humans
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Disease Progression
  • Biopsy, Needle
  • Neoplasm Staging
  • Prognosis
  • Nephrectomy
  • Immunohistochemistry
  • Multivariate Analysis
  • Proportional Hazards Models
  • Sensitivity and Specificity
  • Survival Analysis
  • Cohort Studies
  • Sampling Studies
  • Signal Transduction
  • Gene Expression Regulation, Neoplastic
  • Adult
  • Aged
  • Middle Aged
  • Female
  • Male
  • Proto-Oncogene Proteins c-akt
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases
  • Kaplan-Meier Estimate
  • Biomarkers, Tumor
Sprache
eng
Medium
Print-Electronic
Online publication date
2008
Paginierung
372 - 377
Datum der Veröffentlichung
2008
Status
Published
Datum der Datenerfassung
2008
Titel
Activation of PI3K is associated with reduced survival in renal cell carcinoma.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
80

Data source: Europe PubMed Central

Abstract
OBJECTIVES: The epidermal growth factor receptor- (EGFR) activated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt) pathway is associated with tumorigenesis and progression. The aims of the present study were to determine the expression patterns of Akt pathway parameters PI3K, phosphatase and tensin homolog (PTEN), phosphor-Akt (p-Akt) and their combination, for their possible prognostic value in renal cell carcinoma (RCC). PTEN dephosphorylates the liquid product of PI3K. METHODS: Tumor samples from 176 RCC patients were investigated for PTEN, p-Akt and PI3K expression by immunohistochemistry. Expression levels were correlated to clinical variables and postoperative outcome by uni- and multivariate statistical analysis. RESULTS: The various expression levels within the tumor samples were independent of histological grade and tumor stage, due to different levels of activation of the PI3K/p-Akt pathway. The activation of PI3K protein was found to be significantly associated with reduced survival times (p = 0.0304, multivariate analysis). Analysis of combined biomarker expressions showed that decreased long-term survival was correlated with PTEN low/p-Akt high expression (p < 0.05). CONCLUSIONS: Activation of the PI3K pathway is significantly associated with adverse clinical outcome in RCC. Analysis of biomarker combinations might identify high-risk patients and a subsequent need to adapt treatment modalities. Molecular pathways regulating PI3K activation appear to be promising targets for drug development in the clinical management of RCC patients.
Date of acceptance
2007
Autoren
  • Axel S Merseburger
  • Joerg Hennenlotter
  • Ursula Kuehs
  • Perikles Simon
  • Stephan Kruck
  • Eva Koch
  • Arnulf Stenzl
  • Markus A Kuczyk
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/18587247
DOI
10.1159/000132694
eISSN
1423-0399
Ausgabe der Veröffentlichung
4
Zeitschrift
Urol Int
Schlüsselwörter
  • Adult
  • Aged
  • Biomarkers, Tumor
  • Biopsy, Needle
  • Carcinoma, Renal Cell
  • Cohort Studies
  • Disease Progression
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunohistochemistry
  • Kaplan-Meier Estimate
  • Kidney Neoplasms
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Staging
  • Nephrectomy
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases
  • Prognosis
  • Proportional Hazards Models
  • Proto-Oncogene Proteins c-akt
  • Sampling Studies
  • Sensitivity and Specificity
  • Signal Transduction
  • Survival Analysis
Sprache
eng
Country
Switzerland
Paginierung
372 - 377
PII
000132694
Datum der Veröffentlichung
2008
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2008
Titel
Activation of PI3K is associated with reduced survival in renal cell carcinoma.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
80

Data source: PubMed

Beziehungen:
Property of

Tools