Transport processes of radiopharmaceuticals and -modulators

Publication type:
Journal article
Metadata:
Autoren
  • Thomas Efferth
  • Peter Langguth
Sammlungen
  • metadata
ISSN
1748-717X
Zeitschrift
Radiation oncology
Schlüsselwörter
  • 570 Biowissenschaften
  • 570 Life sciences
Sprache
eng
Paginierung
Seite: 59
Datum der Veröffentlichung
2011
Herausgeber
Biomed Central
Herausgeber URL
http://dx.doi.org/10.1186/1748-717X-6-59
Datum der Datenerfassung
2020
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Zugang
Public
Titel
Transport processes of radiopharmaceuticals and -modulators
Ausgabe der Zeitschrift
6

Data source: METADATA.UB

Other metadata sources:
Autoren
  • Thomas Efferth
  • Peter Langguth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000293073700001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1186/1748-717X-6-59
Externe Identifier
  • Clarivate Analytics Document Solution ID: 796SY
  • PubMed Identifier: 21645349
ISSN
1748-717X
Zeitschrift
RADIATION ONCOLOGY
Schlüsselwörter
  • ABC transporter
  • Multidrug resistance
  • Radioresistance
  • Radioprotection
  • Radiochemotherapy
Artikelnummer
ARTN 59
Datum der Veröffentlichung
2011
Status
Published
Titel
Transport processes of radiopharmaceuticals and -modulators
Sub types
  • Review
Ausgabe der Zeitschrift
6

Data source: Web of Science (Lite)

Autoren
  • Thomas Efferth
  • Peter Langguth
DOI
10.1186/1748-717x-6-59
eISSN
1748-717X
Ausgabe der Veröffentlichung
1
Zeitschrift
Radiation Oncology
Sprache
en
Artikelnummer
59
Online publication date
2011
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1186/1748-717x-6-59
Datum der Datenerfassung
2019
Titel
Transport processes of radiopharmaceuticals and -modulators
Ausgabe der Zeitschrift
6

Data source: Crossref

Abstract
Radiotherapy and radiology have been indispensable components in cancer care for many years. The detection limit of small tumor foci as well as the development of radio-resistance and severe side effects towards normal tissues led to the development of strategies to improve radio-diagnostic and -therapeutic approaches by pharmaceuticals. The term "radiopharmaceutical" has been used for drugs labeled with radioactive tracers for therapy or diagnosis. In addition, drugs have been described to sensitize tumor cells to radiotherapy (radiosensitizers) or to protect normal tissues from detrimental effects of radiation (radioprotectors). The present review summarizes recent concepts on the transport of radiopharmaceuticals, radiosensitizers, and radioprotectors in cells and tissues, e.g. by ATP-binding cassette transporters such as P-glycoprotein. Strengths and weaknesses of current strategies to improve transport-based processes are discussed.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University, Mainz, Germany. efferth@uni-mainz.de
Autoren
DOI
10.1186/1748-717x-6-59
eISSN
1748-717X
Externe Identifier
  • PubMed Identifier: 21645349
  • PubMed Central ID: PMC3141524
Open access
true
ISSN
1748-717X
Zeitschrift
Radiation oncology (London, England)
Schlüsselwörter
  • Animals
  • Humans
  • Neoplasms
  • Reactive Oxygen Species
  • Technetium Tc 99m Sestamibi
  • Fluorodeoxyglucose F18
  • Radiation-Sensitizing Agents
  • Radiopharmaceuticals
  • Radionuclide Imaging
  • Radiotherapy
  • Nuclear Medicine
  • Gene Expression Regulation
  • Biological Transport
  • Chemoradiotherapy
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Electronic
Online publication date
2011
Open access status
Open Access
Paginierung
59
Datum der Veröffentlichung
2011
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2011
Titel
Transport processes of radiopharmaceuticals and -modulators.
Sub types
  • review-article
  • Review
  • Journal Article
Ausgabe der Zeitschrift
6

Files

https://ro-journal.biomedcentral.com/track/pdf/10.1186/1748-717X-6-59 https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21645349/pdf/?tool=EBI https://europepmc.org/articles/PMC3141524?pdf=render

Data source: Europe PubMed Central

Abstract
Radiotherapy and radiology have been indispensable components in cancer care for many years. The detection limit of small tumor foci as well as the development of radio-resistance and severe side effects towards normal tissues led to the development of strategies to improve radio-diagnostic and -therapeutic approaches by pharmaceuticals. The term "radiopharmaceutical" has been used for drugs labeled with radioactive tracers for therapy or diagnosis. In addition, drugs have been described to sensitize tumor cells to radiotherapy (radiosensitizers) or to protect normal tissues from detrimental effects of radiation (radioprotectors). The present review summarizes recent concepts on the transport of radiopharmaceuticals, radiosensitizers, and radioprotectors in cells and tissues, e.g. by ATP-binding cassette transporters such as P-glycoprotein. Strengths and weaknesses of current strategies to improve transport-based processes are discussed.
Date of acceptance
2011
Autoren
  • Thomas Efferth
  • Peter Langguth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21645349
DOI
10.1186/1748-717X-6-59
eISSN
1748-717X
Externe Identifier
  • PubMed Central ID: PMC3141524
Zeitschrift
Radiat Oncol
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Animals
  • Biological Transport
  • Chemoradiotherapy
  • Fluorodeoxyglucose F18
  • Gene Expression Regulation
  • Humans
  • Neoplasms
  • Nuclear Medicine
  • Radiation-Sensitizing Agents
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Radiotherapy
  • Reactive Oxygen Species
  • Technetium Tc 99m Sestamibi
Sprache
eng
Country
England
Paginierung
59
PII
1748-717X-6-59
Datum der Veröffentlichung
2011
Status
Published online
Datum, an dem der Datensatz öffentlich gemacht wurde
2012
Titel
Transport processes of radiopharmaceuticals and -modulators.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
6

Data source: PubMed

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