Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- R Ragg
- AM Schilmann
- K Korschelt
- C Wieseotte
- M Kluenker
- M Viel
- L Voelker
- S Preiss
- J Herzberger
- H Frey
- K Heinze
- P Bluemler
- MN Tahir
- F Natalio
- W Tremel
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000389666000010&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1039/c6tb02078j
- eISSN
- 2050-7518
- Externe Identifier
- Clarivate Analytics Document Solution ID: EE5RS
- PubMed Identifier: 32263743
- ISSN
- 2050-750X
- Ausgabe der Veröffentlichung
- 46
- Zeitschrift
- JOURNAL OF MATERIALS CHEMISTRY B
- Paginierung
- 7423 - 7428
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast
- Sub types
- Article
- Ausgabe der Zeitschrift
- 4
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <p>MnO nanoparticles decompose superoxide and hydrogen peroxide in an enzyme-like manner leading to enhanced MRI contrast.</p>
- Autoren
- R Ragg
- AM Schilmann
- K Korschelt
- C Wieseotte
- M Kluenker
- M Viel
- L Völker
- S Preiß
- J Herzberger
- H Frey
- K Heinze
- P Blümler
- MN Tahir
- F Natalio
- W Tremel
- DOI
- 10.1039/c6tb02078j
- eISSN
- 2050-7518
- ISSN
- 2050-750X
- Ausgabe der Veröffentlichung
- 46
- Zeitschrift
- Journal of Materials Chemistry B
- Sprache
- en
- Online publication date
- 2016
- Paginierung
- 7423 - 7428
- Status
- Published online
- Herausgeber
- Royal Society of Chemistry (RSC)
- Herausgeber URL
- http://dx.doi.org/10.1039/c6tb02078j
- Datum der Datenerfassung
- 2024
- Titel
- Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast
- Ausgabe der Zeitschrift
- 4
Data source: Crossref
- Abstract
- Superoxide radicals are associated with the development of many severe diseases, such as cancer. Under nonpathogenic conditions, the natural enzyme superoxide dismutase (SOD) regulates the intracellular superoxide concentrations, but nearly all tumor tissues show reduced SOD levels. Selective imaging in early progression stages remains a key requirement for efficient cancer diagnosis and treatment. Magnetic resonance imaging (MRI) as a noninvasive tool with high spatial resolution may offer advantages here, but MRI contrast agents exhibiting a redox-triggered change in the image contrast towards superoxide radicals have not been reported so far. Here we show that manganese oxide (MnO) nanoparticles (NPs) exhibit an intrinsic SOD-like activity, which is higher than that of the native Mn-dependent SOD. In addition, MnO NPs significantly enhance the MRI contrast when exposed to superoxide radicals, making them responsive MRI contrast agents for the treatment and imaging of cancer cells with reduced SOD levels.
- Addresses
- Institute of Inorganic and Analytical Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany. tremel@uni-mainz.de tahir@uni-mainz.de.
- Autoren
- R Ragg
- AM Schilmann
- K Korschelt
- C Wieseotte
- M Kluenker
- M Viel
- L Völker
- S Preiß
- J Herzberger
- H Frey
- K Heinze
- P Blümler
- MN Tahir
- F Natalio
- W Tremel
- DOI
- 10.1039/c6tb02078j
- eISSN
- 2050-7518
- Externe Identifier
- PubMed Identifier: 32263743
- Open access
- false
- ISSN
- 2050-750X
- Ausgabe der Veröffentlichung
- 46
- Zeitschrift
- Journal of materials chemistry. B
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2016
- Paginierung
- 7423 - 7428
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum der Datenerfassung
- 2020
- Titel
- Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 4
Data source: Europe PubMed Central
- Abstract
- Superoxide radicals are associated with the development of many severe diseases, such as cancer. Under nonpathogenic conditions, the natural enzyme superoxide dismutase (SOD) regulates the intracellular superoxide concentrations, but nearly all tumor tissues show reduced SOD levels. Selective imaging in early progression stages remains a key requirement for efficient cancer diagnosis and treatment. Magnetic resonance imaging (MRI) as a noninvasive tool with high spatial resolution may offer advantages here, but MRI contrast agents exhibiting a redox-triggered change in the image contrast towards superoxide radicals have not been reported so far. Here we show that manganese oxide (MnO) nanoparticles (NPs) exhibit an intrinsic SOD-like activity, which is higher than that of the native Mn-dependent SOD. In addition, MnO NPs significantly enhance the MRI contrast when exposed to superoxide radicals, making them responsive MRI contrast agents for the treatment and imaging of cancer cells with reduced SOD levels.
- Autoren
- R Ragg
- AM Schilmann
- K Korschelt
- C Wieseotte
- M Kluenker
- M Viel
- L Völker
- S Preiß
- J Herzberger
- H Frey
- K Heinze
- P Blümler
- MN Tahir
- F Natalio
- W Tremel
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/32263743
- DOI
- 10.1039/c6tb02078j
- eISSN
- 2050-7518
- Ausgabe der Veröffentlichung
- 46
- Zeitschrift
- J Mater Chem B
- Sprache
- eng
- Country
- England
- Paginierung
- 7423 - 7428
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 4
Data source: PubMed
- Beziehungen:
- Property of