Oligomerization of polytopic α-helical membrane proteins: causes and consequences

Publication type:
Journal article
Metadata:
Abstract
<jats:title>Abstract</jats:title> <jats:p>Several polytopic α-helical membrane-integrated proteins appear to be organized in higher-ordered oligomeric complexes. While many aspects are still enigmatic, in recent years, the physiological impact of membrane protein oligomerization has been analyzed to some extent. In the present article, oligomerization of structurally well-defined membrane proteins is discussed. The available experimental information indicates the causes and physiological consequences of membrane protein oligomerization, including stabilization, cooperative functions, and control of specific activities. Based on the currently available observations, we aim to derive some general principles and discuss open questions.</jats:p>
Autoren
  • Florian Cymer
  • Dirk Schneider
DOI
10.1515/hsz-2012-0231
eISSN
1437-4315
ISSN
1431-6730
Ausgabe der Veröffentlichung
11
Zeitschrift
bchm
Sprache
en
Online publication date
2012
Paginierung
1215 - 1230
Datum der Veröffentlichung
2012
Status
Published
Herausgeber
Walter de Gruyter GmbH
Herausgeber URL
http://dx.doi.org/10.1515/hsz-2012-0231
Datum der Datenerfassung
2022
Titel
Oligomerization of polytopic α-helical membrane proteins: causes and consequences
Ausgabe der Zeitschrift
393

Data source: Crossref

Other metadata sources:
Abstract
Several polytopic α-helical membrane-integrated proteins appear to be organized in higher-ordered oligomeric complexes. While many aspects are still enigmatic, in recent years, the physiological impact of membrane protein oligomerization has been analyzed to some extent. In the present article, oligomerization of structurally well-defined membrane proteins is discussed. The available experimental information indicates the causes and physiological consequences of membrane protein oligomerization, including stabilization, cooperative functions, and control of specific activities. Based on the currently available observations, we aim to derive some general principles and discuss open questions.
Addresses
  • Institut für Pharmazie und Biochemie, Johannes Gutenberg-Universität Mainz, Johann-Joachim-Becher-Weg 30, D-55128 Mainz, Deutschland. Florian.Cymer@dbb.su.se
Autoren
  • Florian Cymer
  • Dirk Schneider
DOI
10.1515/hsz-2012-0231
eISSN
1437-4315
Externe Identifier
  • PubMed Identifier: 23096346
Open access
false
ISSN
1431-6730
Ausgabe der Veröffentlichung
11
Zeitschrift
Biological chemistry
Schlüsselwörter
  • Humans
  • Membrane Proteins
  • Protein Structure, Secondary
  • Models, Molecular
  • Protein Stability
Sprache
eng
Medium
Print
Paginierung
1215 - 1230
Datum der Veröffentlichung
2012
Status
Published
Datum der Datenerfassung
2012
Titel
Oligomerization of polytopic α-helical membrane proteins: causes and consequences.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
393

Data source: Europe PubMed Central

Abstract
Several polytopic α-helical membrane-integrated proteins appear to be organized in higher-ordered oligomeric complexes. While many aspects are still enigmatic, in recent years, the physiological impact of membrane protein oligomerization has been analyzed to some extent. In the present article, oligomerization of structurally well-defined membrane proteins is discussed. The available experimental information indicates the causes and physiological consequences of membrane protein oligomerization, including stabilization, cooperative functions, and control of specific activities. Based on the currently available observations, we aim to derive some general principles and discuss open questions.
Date of acceptance
2012
Autoren
  • Florian Cymer
  • Dirk Schneider
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/23096346
DOI
10.1515/hsz-2012-0231
eISSN
1437-4315
Ausgabe der Veröffentlichung
11
Zeitschrift
Biol Chem
Schlüsselwörter
  • Humans
  • Membrane Proteins
  • Models, Molecular
  • Protein Stability
  • Protein Structure, Secondary
Sprache
eng
Country
Germany
Paginierung
1215 - 1230
PII
/j/bchm.just-accepted/hsz-2012-0231/hsz-2012-0231.xml
Datum der Veröffentlichung
2012
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2014
Titel
Oligomerization of polytopic α-helical membrane proteins: causes and consequences.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
393

Data source: PubMed

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