Functional competition within a membrane: Lipid recognition vs. transmembrane helix oligomerization

Publication type:
Journal article
Metadata:
Autoren
  • Michael Stangl
  • Dirk Schneider
DOI
10.1016/j.bbamem.2015.03.011
ISSN
0005-2736
Ausgabe der Veröffentlichung
9
Zeitschrift
Biochimica et Biophysica Acta (BBA) - Biomembranes
Sprache
en
Paginierung
1886 - 1896
Datum der Veröffentlichung
2015
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.bbamem.2015.03.011
Datum der Datenerfassung
2022
Titel
Functional competition within a membrane: Lipid recognition vs. transmembrane helix oligomerization
Ausgabe der Zeitschrift
1848

Data source: Crossref

Other metadata sources:
Abstract
Binding of specific lipids to large, polytopic membrane proteins is well described, and it is clear that such lipids are crucial for protein stability and activity. In contrast, binding of defined lipid species to individual transmembrane helices and regulation of transmembrane helix monomer-oligomer equilibria by binding of distinct lipids is a concept, which has emerged only lately. Lipids bind to single-span membrane proteins, both in the juxta-membrane region as well as in the hydrophobic membrane core. While some interactions counteract transmembrane helix oligomerization, in other cases lipid binding appears to enhance oligomerization. As reversible oligomerization is involved in activation of many membrane proteins, binding of defined lipids to single-span transmembrane proteins might be a mechanism to regulate and/or fine-tune the protein activity. But how could lipid binding trigger the activity of a protein? How can binding of a single lipid molecule to a transmembrane helix affect the structure of a transmembrane helix oligomer, and consequently its signaling state? These questions are discussed in the present article based on recent results obtained with simple, single-span transmembrane proteins. This article is part of a Special Issue entitled: Lipid-protein interactions.
Addresses
  • Department of Pharmacy and Biochemistry, Johannes-Gutenberg-University Mainz, Johann-Joachim-Becher-Weg 30, 55128 Mainz, Germany.
Autoren
  • Michael Stangl
  • Dirk Schneider
DOI
10.1016/j.bbamem.2015.03.011
eISSN
1878-2434
Externe Identifier
  • PubMed Identifier: 25791349
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft:
  • Stiftung Rheinland-Pfalz für Innovation:
Open access
false
ISSN
0006-3002
Ausgabe der Veröffentlichung
9
Zeitschrift
Biochimica et biophysica acta
Schlüsselwörter
  • Cell Membrane
  • Membrane Lipids
  • Lipid Bilayers
  • Membrane Proteins
  • Binding, Competitive
  • Molecular Structure
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Protein Binding
  • Models, Molecular
Sprache
eng
Medium
Print-Electronic
Online publication date
2015
Paginierung
1886 - 1896
Datum der Veröffentlichung
2015
Status
Published
Datum der Datenerfassung
2015
Titel
Functional competition within a membrane: Lipid recognition vs. transmembrane helix oligomerization.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
1848

Data source: Europe PubMed Central

Abstract
Binding of specific lipids to large, polytopic membrane proteins is well described, and it is clear that such lipids are crucial for protein stability and activity. In contrast, binding of defined lipid species to individual transmembrane helices and regulation of transmembrane helix monomer-oligomer equilibria by binding of distinct lipids is a concept, which has emerged only lately. Lipids bind to single-span membrane proteins, both in the juxta-membrane region as well as in the hydrophobic membrane core. While some interactions counteract transmembrane helix oligomerization, in other cases lipid binding appears to enhance oligomerization. As reversible oligomerization is involved in activation of many membrane proteins, binding of defined lipids to single-span transmembrane proteins might be a mechanism to regulate and/or fine-tune the protein activity. But how could lipid binding trigger the activity of a protein? How can binding of a single lipid molecule to a transmembrane helix affect the structure of a transmembrane helix oligomer, and consequently its signaling state? These questions are discussed in the present article based on recent results obtained with simple, single-span transmembrane proteins. This article is part of a Special Issue entitled: Lipid-protein interactions.
Date of acceptance
2015
Autoren
  • Michael Stangl
  • Dirk Schneider
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/25791349
DOI
10.1016/j.bbamem.2015.03.011
ISSN
0006-3002
Ausgabe der Veröffentlichung
9
Zeitschrift
Biochim Biophys Acta
Schlüsselwörter
  • C99
  • Lipid binding
  • Membrane protein
  • Oligomerization
  • Syntaxin 1A
  • p24
  • Binding, Competitive
  • Cell Membrane
  • Lipid Bilayers
  • Membrane Lipids
  • Membrane Proteins
  • Models, Molecular
  • Molecular Structure
  • Protein Binding
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
Sprache
eng
Country
Netherlands
Paginierung
1886 - 1896
PII
S0005-2736(15)00090-5
Datum der Veröffentlichung
2015
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2015
Titel
Functional competition within a membrane: Lipid recognition vs. transmembrane helix oligomerization.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
1848

Data source: PubMed

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