State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives

Publication type:
Journal article
Metadata:
Abstract
<jats:p>Background: Despite some evidence supporting the synergy concept, the commonly known assumption that combinations of several herbs in one formulation can have better efficacy due to additive or synergistic effects has yet to be unambiguously and explicitly studied. Study aim: The study aimed to reveal the molecular interactions in situ of host cells in response to botanical hybrid preparations (BHP) intervention and justify the benefits of implementing BHP in clinical practice. Results: This prospective literature review provides the results of recent clinical and network pharmacology studies of BHP of Rhodiola rosea L. (Arctic root) with other plants, including Withania somnifera (L.) Dunal (ashwagandha), (Camellia sinensis (L.) Kuntze (green tea), Eleutherococcus senticosus (Rupr. and Maxim.) Maxim. (eleuthero), Schisandra chinensis (Turcz.) Baill. (schisandra), Leuzea carthamoides (Willd.) DC., caffeine, Cordyceps militaris L., Ginkgo biloba L.(ginkgo), Actaea racemosa L. (black cohosh), Crocus sativus L. (saffron), and L-carnosine. Conclusions: The most important finding from network pharmacology studies of BHP was the evidence supporting the synergistic interaction of BHP ingredients, revealing unexpected new pharmacological activities unique and specific to the new BHP. Some studies show the superior efficacy of BHP compared to mono-drugs. At the same time, some a priori-designed combinations can fail, presumably due to antagonistic interactions and crosstalk between molecular targets within the molecular networks involved in the cellular and overall response of organisms to the intervention. Network pharmacology studies help predict the results of studies aimed at discovering new indications and unpredicted adverse events.</jats:p>
Autoren
DOI
10.3390/ph17040483
eISSN
1424-8247
Ausgabe der Veröffentlichung
4
Zeitschrift
Pharmaceuticals
Sprache
en
Online publication date
2024
Paginierung
483 - 483
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/ph17040483
Datum der Datenerfassung
2024
Titel
State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives
Ausgabe der Zeitschrift
17

Data source: Crossref

Other metadata sources:
Abstract
<h4>Background</h4>Despite some evidence supporting the synergy concept, the commonly known assumption that combinations of several herbs in one formulation can have better efficacy due to additive or synergistic effects has yet to be unambiguously and explicitly studied.<h4>Study aim</h4>The study aimed to reveal the molecular interactions in situ of host cells in response to botanical hybrid preparations (BHP) intervention and justify the benefits of implementing BHP in clinical practice.<h4>Results</h4>This prospective literature review provides the results of recent clinical and network pharmacology studies of BHP of <i>Rhodiola rosea</i> L. (Arctic root) with other plants, including <i>Withania somnifera</i> (L.) Dunal (ashwagandha), (<i>Camellia sinensis</i> (L.) Kuntze (green tea), <i>Eleutherococcus senticosus</i> (Rupr. and Maxim.) Maxim. (eleuthero), <i>Schisandra chinensis</i> (Turcz.) Baill. (schisandra), <i>Leuzea carthamoides</i> (Willd.) DC., caffeine, <i>Cordyceps militaris</i> L., <i>Ginkgo biloba</i> L.(ginkgo), <i>Actaea racemosa</i> L. (black cohosh), <i>Crocus sativus</i> L. (saffron), and L-carnosine.<h4>Conclusions</h4>The most important finding from network pharmacology studies of BHP was the evidence supporting the synergistic interaction of BHP ingredients, revealing unexpected new pharmacological activities unique and specific to the new BHP. Some studies show the superior efficacy of BHP compared to mono-drugs. At the same time, some a priori-designed combinations can fail, presumably due to antagonistic interactions and crosstalk between molecular targets within the molecular networks involved in the cellular and overall response of organisms to the intervention. Network pharmacology studies help predict the results of studies aimed at discovering new indications and unpredicted adverse events.
Addresses
  • Phytomed AB, Sjöstadsvägen 6A, Lgh 1004, 59344 Västervik, Sweden.
Autoren
DOI
10.3390/ph17040483
eISSN
1424-8247
Externe Identifier
  • PubMed Identifier: 38675443
  • PubMed Central ID: PMC11053582
Open access
true
ISSN
1424-8247
Ausgabe der Veröffentlichung
4
Zeitschrift
Pharmaceuticals (Basel, Switzerland)
Sprache
eng
Medium
Electronic
Online publication date
2024
Open access status
Open Access
Paginierung
483
Datum der Veröffentlichung
2024
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2024
Titel
State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives.
Sub types
  • review-article
  • Review
  • Journal Article
Ausgabe der Zeitschrift
17

Files

https://europepmc.org/articles/PMC11053582?pdf=render

Data source: Europe PubMed Central

Abstract
BACKGROUND: Despite some evidence supporting the synergy concept, the commonly known assumption that combinations of several herbs in one formulation can have better efficacy due to additive or synergistic effects has yet to be unambiguously and explicitly studied. STUDY AIM: The study aimed to reveal the molecular interactions in situ of host cells in response to botanical hybrid preparations (BHP) intervention and justify the benefits of implementing BHP in clinical practice. RESULTS: This prospective literature review provides the results of recent clinical and network pharmacology studies of BHP of Rhodiola rosea L. (Arctic root) with other plants, including Withania somnifera (L.) Dunal (ashwagandha), (Camellia sinensis (L.) Kuntze (green tea), Eleutherococcus senticosus (Rupr. and Maxim.) Maxim. (eleuthero), Schisandra chinensis (Turcz.) Baill. (schisandra), Leuzea carthamoides (Willd.) DC., caffeine, Cordyceps militaris L., Ginkgo biloba L.(ginkgo), Actaea racemosa L. (black cohosh), Crocus sativus L. (saffron), and L-carnosine. CONCLUSIONS: The most important finding from network pharmacology studies of BHP was the evidence supporting the synergistic interaction of BHP ingredients, revealing unexpected new pharmacological activities unique and specific to the new BHP. Some studies show the superior efficacy of BHP compared to mono-drugs. At the same time, some a priori-designed combinations can fail, presumably due to antagonistic interactions and crosstalk between molecular targets within the molecular networks involved in the cellular and overall response of organisms to the intervention. Network pharmacology studies help predict the results of studies aimed at discovering new indications and unpredicted adverse events.
Date of acceptance
2024
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/38675443
DOI
10.3390/ph17040483
Externe Identifier
  • PubMed Central ID: PMC11053582
ISSN
1424-8247
Ausgabe der Veröffentlichung
4
Zeitschrift
Pharmaceuticals (Basel)
Schlüsselwörter
  • Rhodiola rosea clinical trials
  • botanical hybrid preparations
  • gene expression
  • network pharmacology
  • synergy
Sprache
eng
Country
Switzerland
PII
ph17040483
Datum der Veröffentlichung
2024
Status
Published online
Titel
State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
17

Data source: PubMed

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