Molecular networking-guided investigation of the secondary metabolome of four Morus species and their in vivo neuroprotective potential for the mitigation of Alzheimer's disease

Publication type:
Journal article
Metadata:
Autoren
  • Nesrine M Hegazi
  • Tarik A Mohamed
  • Abeer Salama
  • Ahmed R Hamed
  • Hamada H Saad
  • Ibrahim A Saleh
  • Eman H Reda
  • Ahmed AA Elsayed
  • Mahmoud AA Ibrahim
  • Paul W Pare
  • Thomas Efferth
  • Mohamed-Elamir F Hegazy
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:001191282900001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1039/d3fo05711a
eISSN
2042-650X
Externe Identifier
  • Clarivate Analytics Document Solution ID: OE8T4
  • PubMed Identifier: 38533683
ISSN
2042-6496
Ausgabe der Veröffentlichung
8
Zeitschrift
FOOD & FUNCTION
Paginierung
4354 - 4364
Datum der Veröffentlichung
2024
Status
Published
Titel
Molecular networking-guided investigation of the secondary metabolome of four <i>Morus</i> species and their <i>in vivo</i> neuroprotective potential for the mitigation of Alzheimer&apos;s disease
Sub types
  • Article
Ausgabe der Zeitschrift
15

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:p>Neuroprotective effects of Morus speices for the mitigation of Alzeheimer's Disease and investigation of their secondary metabolome diversity.</jats:p>
Autoren
  • Nesrine M Hegazi
  • Tarik A Mohamed
  • Abeer Salama
  • Ahmed R Hamed
  • Hamada H Saad
  • Ibrahim A Saleh
  • Eman H Reda
  • Ahmed AA Elsayed
  • Mahmoud AA Ibrahim
  • Paul W Paré
  • Thomas Efferth
  • Mohamed-Elamir F Hegazy
DOI
10.1039/d3fo05711a
eISSN
2042-650X
ISSN
2042-6496
Ausgabe der Veröffentlichung
8
Zeitschrift
Food &amp; Function
Sprache
en
Online publication date
2024
Paginierung
4354 - 4364
Status
Published online
Herausgeber
Royal Society of Chemistry (RSC)
Herausgeber URL
http://dx.doi.org/10.1039/d3fo05711a
Datum der Datenerfassung
2024
Titel
Molecular networking-guided investigation of the secondary metabolome of four <i>Morus</i> species and their <i>in vivo</i> neuroprotective potential for the mitigation of Alzheimer's disease
Ausgabe der Zeitschrift
15

Data source: Crossref

Abstract
Alzheimer's Disease (AD) is a fatal age-related neurodegenerative condition with a multifactorial etiology contributing to 70% of dementia globally. The search for a multi-target agent to hit different targets involved in the pathogenesis of AD is crucial. In the present study, the neuroprotective effects of four <i>Morus</i> extracts were assessed in LPS-induced AD in mice. Among the studied species, <i>M. macroura</i> exhibited a profound effect on alleviating the loss of cognitive function, improved the learning ability, restored the acetylcholine esterase (AChE) levels to normal, and significantly reduced the tumor necrosis factor alpha (TNF-α) brain content in LPS-treated mice. To investigate the secondary metabolome of the studied <i>Morus</i> species, ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-HRMS/MS), aided with feature-based molecular networking, was employed. Among the annotated features, aryl benzofurans and prenylated flavonoids were suggested as being responsible for the observed neuroprotective effect. Furthermore, some of the detected metabolites were proposed as new natural products such as moranoline di-<i>O</i>-hexoside (1), isomers of trimethoxy-dihydrochalcone-<i>O</i>-dihexoside (59 & 76), (hydroxy-dimethoxyphenyl)butenone-<i>O</i>-hexoside (82), and <i>O</i>-methylpreglabridin-<i>O</i>-sulphate (105). In conclusion, our findings advocate the potential usage of <i>M. macroura</i> leaves for the management of AD, yet after considering further clinical trials.
Addresses
  • Phytochemistry and Plant Systematics Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt. nm.hegazi@nrc.sci.eg.
Autoren
  • Nesrine M Hegazi
  • Tarik A Mohamed
  • Abeer Salama
  • Ahmed R Hamed
  • Hamada H Saad
  • Ibrahim A Saleh
  • Eman H Reda
  • Ahmed AA Elsayed
  • Mahmoud AA Ibrahim
  • Paul W Paré
  • Thomas Efferth
  • Mohamed-Elamir F Hegazy
DOI
10.1039/d3fo05711a
eISSN
2042-650X
Externe Identifier
  • PubMed Identifier: 38533683
Open access
false
ISSN
2042-6496
Ausgabe der Veröffentlichung
8
Zeitschrift
Food & function
Schlüsselwörter
  • Brain
  • Animals
  • Humans
  • Mice
  • Morus
  • Alzheimer Disease
  • Disease Models, Animal
  • Neuroprotective Agents
  • Plant Extracts
  • Chromatography, High Pressure Liquid
  • Male
  • Tandem Mass Spectrometry
  • Metabolome
Sprache
eng
Medium
Electronic
Online publication date
2024
Paginierung
4354 - 4364
Datum der Veröffentlichung
2024
Status
Published
Datum der Datenerfassung
2024
Titel
Molecular networking-guided investigation of the secondary metabolome of four <i>Morus</i> species and their <i>in vivo</i> neuroprotective potential for the mitigation of Alzheimer's disease.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
15

Data source: Europe PubMed Central

Abstract
Alzheimer's Disease (AD) is a fatal age-related neurodegenerative condition with a multifactorial etiology contributing to 70% of dementia globally. The search for a multi-target agent to hit different targets involved in the pathogenesis of AD is crucial. In the present study, the neuroprotective effects of four Morus extracts were assessed in LPS-induced AD in mice. Among the studied species, M. macroura exhibited a profound effect on alleviating the loss of cognitive function, improved the learning ability, restored the acetylcholine esterase (AChE) levels to normal, and significantly reduced the tumor necrosis factor alpha (TNF-α) brain content in LPS-treated mice. To investigate the secondary metabolome of the studied Morus species, ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-HRMS/MS), aided with feature-based molecular networking, was employed. Among the annotated features, aryl benzofurans and prenylated flavonoids were suggested as being responsible for the observed neuroprotective effect. Furthermore, some of the detected metabolites were proposed as new natural products such as moranoline di-O-hexoside (1), isomers of trimethoxy-dihydrochalcone-O-dihexoside (59 & 76), (hydroxy-dimethoxyphenyl)butenone-O-hexoside (82), and O-methylpreglabridin-O-sulphate (105). In conclusion, our findings advocate the potential usage of M. macroura leaves for the management of AD, yet after considering further clinical trials.
Autoren
  • Nesrine M Hegazi
  • Tarik A Mohamed
  • Abeer Salama
  • Ahmed R Hamed
  • Hamada H Saad
  • Ibrahim A Saleh
  • Eman H Reda
  • Ahmed AA Elsayed
  • Mahmoud AA Ibrahim
  • Paul W Paré
  • Thomas Efferth
  • Mohamed-Elamir F Hegazy
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/38533683
DOI
10.1039/d3fo05711a
eISSN
2042-650X
Ausgabe der Veröffentlichung
8
Zeitschrift
Food Funct
Schlüsselwörter
  • Animals
  • Alzheimer Disease
  • Neuroprotective Agents
  • Mice
  • Plant Extracts
  • Male
  • Morus
  • Metabolome
  • Tandem Mass Spectrometry
  • Disease Models, Animal
  • Chromatography, High Pressure Liquid
  • Humans
  • Brain
Sprache
eng
Country
England
Paginierung
4354 - 4364
Datum der Veröffentlichung
2024
Status
Published online
Datum, an dem der Datensatz öffentlich gemacht wurde
2024
Titel
Molecular networking-guided investigation of the secondary metabolome of four Morus species and their in vivo neuroprotective potential for the mitigation of Alzheimer's disease.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
15

Data source: PubMed

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