Translating Pathological Brain Activity Primers in Parkinson’s Disease Research
- Publication type:
- Journal article
- Metadata:
-
- Abstract
- <jats:p>Translational experimental approaches that help us better trace Parkinson’s disease (PD) pathophysiological mechanisms leading to new therapeutic targets are urgently needed. In this article, we review recent experimental and clinical studies addressing abnormal neuronal activity and pathological network oscillations, as well as their underlying mechanisms and modulation. Our aim is to enhance our knowledge about the progression of Parkinson's disease pathology and the timing of its symptom’s manifestation. Here, we present mechanistic insights relevant for the generation of aberrant oscillatory activity within the cortico-basal ganglia circuits. We summarize recent achievements extrapolated from available PD animal models, discuss their advantages and limitations, debate on their differential applicability, and suggest approaches for transferring knowledge on disease pathology into future research and clinical applications.</jats:p>
- Autoren
- Daniela Mirzac
- Svenja L Kreis
- Heiko J Luhmann
- Gabriel Gonzalez-Escamilla
- Sergiu Groppa
- DOI
- 10.34133/research.0183
- eISSN
- 2639-5274
- Zeitschrift
- Research
- Sprache
- en
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Herausgeber
- American Association for the Advancement of Science (AAAS)
- Herausgeber URL
- http://dx.doi.org/10.34133/research.0183
- Datum der Datenerfassung
- 2023
- Titel
- Translating Pathological Brain Activity Primers in Parkinson’s Disease Research
- Ausgabe der Zeitschrift
- 6
Data source: Crossref
- Other metadata sources:
-
- Author's licence
- CC-BY
- Autoren
- Daniela Mirzac
- Svenja L Kreis
- Heiko J Luhmann
- Gabriel Gonzalez-Escamilla
- Sergiu Groppa
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- DFG-491381577-G
- Resource version
- Published version
- DOI
- 10.34133/research.0183
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 2639-5274
- Zeitschrift
- Research
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 0183
- Datum der Veröffentlichung
- 2023
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/10041
- Herausgeber
- China Association for Science and Technology
- Datum der Datenerfassung
- 2024
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2024
- Zugang
- Public
- Titel
- Translating pathological brain activity primers in Parkinson’s disease research
- Ausgabe der Zeitschrift
- 6
Files
translating_pathological_brai-20240201175156139.pdf
Data source: OPENSCIENCE.UB