Quality of life after pediatric cancer: comparison of long-term childhood cancer survivors’ quality of life with a representative general population sample and associations with physical health and risk indicators

Publication type:
Journal article
Metadata:
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>This study aimed to compare the quality of life (QoL) reported by childhood cancer survivors (CCS) drawn from a cohort of the German Childhood Cancer Registry with a representative general population sample and, within CCS, to test associations between QoL and health behavior, health risk factors, and physical illness.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>CCS (<jats:italic>N</jats:italic> = 633, age at diagnosis <jats:italic>M</jats:italic> = 6.34 (<jats:italic>SD</jats:italic> = 4.38), age at medical assessment <jats:italic>M</jats:italic> = 34.92 (<jats:italic>SD</jats:italic> = 5.70)) and a general population sample (age-aligned; <jats:italic>N</jats:italic> = 975) filled out the EORTC QLQ-C30. Comparisons were performed using General linear models (GLMs) (fixed effects: sex/gender, group (CCS vs. general population); covariates: age, education level). CCS underwent an extensive medical assessment (mean time from diagnosis to assessment was 28.07 (<jats:italic>SD</jats:italic> = 3.21) years) including an objective diagnosis of health risk factors and physical illnesses (e.g., diabetes and cardiovascular disease). Within CCS, we tested associations between QoL and sociodemographic characteristics, health behavior, health risk factors, and physical illness.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>CCS, especially female CCS, reported both worse functional QoL and higher symptom burden than the general population. Among CCS, better total QoL was related to younger age, higher level of education, being married, and engaging in active sports. Both health risk factors (dyslipidemia and physical inactivity) and manifest physical illnesses (cardiovascular disease) were associated with lower total QoL.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>In all domains, long-term CCS reported worse QoL than the comparison sample. The negative associations with risk factors and physical illnesses indicate an urgent need for long-term surveillance and health promotion.</jats:p> </jats:sec>
Autoren
  • Mareike Ernst
  • Andreas Hinz
  • Elmar Brähler
  • Hiltrud Merzenich
  • Jörg Faber
  • Philipp S Wild
  • Manfred E Beutel
DOI
10.1186/s12955-023-02153-7
eISSN
1477-7525
Ausgabe der Veröffentlichung
1
Zeitschrift
Health and Quality of Life Outcomes
Sprache
en
Artikelnummer
65
Online publication date
2023
Status
Published online
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1186/s12955-023-02153-7
Datum der Datenerfassung
2023
Titel
Quality of life after pediatric cancer: comparison of long-term childhood cancer survivors’ quality of life with a representative general population sample and associations with physical health and risk indicators
Ausgabe der Zeitschrift
21

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY
Autoren
  • Mareike Ernst
  • Andreas Hinz
  • Elmar Brähler
  • Hiltrud Merzenich
  • Jörg Faber
  • Philipp S Wild
  • Manfred E Beutel
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-G
Resource version
Published version
DOI
10.1186/s12955-023-02153-7
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft (DFG)|491381577|Open-Access-Publikationskosten 2022–2024 Universität Mainz - Universitätsmedizin
File(s) embargoed
false
Open access
true
ISSN
1477-7525
Zeitschrift
Health and quality of life outcomes
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
65
Datum der Veröffentlichung
2023
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/10036
Herausgeber
BioMed Central
Datum der Datenerfassung
2024
Datum, an dem der Datensatz öffentlich gemacht wurde
2024
Zugang
Public
Titel
Quality of life after pediatric cancer : comparison of long-term childhood cancer survivors’ quality of life with a representative general population sample and associations with physical health and risk indicators
Ausgabe der Zeitschrift
21

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quality_of_life_after_pediatr-20240201171141465.pdf

Data source: OPENSCIENCE.UB

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