Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2

Publication type:
Journal article
Metadata:
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term.</jats:p> </jats:sec><jats:sec> <jats:title>Graphical Abstract</jats:title> </jats:sec>
Autoren
  • Anna C Mavromanoli
  • Stefano Barco
  • Walter Ageno
  • Hélène Bouvaist
  • Marianne Brodmann
  • Claudio Cuccia
  • Francis Couturaud
  • Claudia Dellas
  • Konstantinos Dimopoulos
  • Daniel Duerschmied
  • Klaus Empen
  • Pompilio Faggiano
  • Emile Ferrari
  • Nazzareno Galiè
  • Marcello Galvani
  • Alexandre Ghuysen
  • George Giannakoulas
  • Menno V Huisman
  • David Jiménez
  • Matija Kozak
  • Irene M Lang
  • Nicolas Meneveau
  • Thomas Münzel
  • Massimiliano Palazzini
  • Antoniu Octavian Petris
  • Giancarlo Piovaccari
  • Aldo Salvi
  • Sebastian Schellong
  • Kai-Helge Schmidt
  • Franck Verschuren
  • Irene Schmidtmann
  • Gerrit Toenges
  • Frederikus A Klok
  • Stavros V Konstantinides
  • Jaime Antonio Abelaira Freire
  • Ibrahim Akin
  • Toni Anusic
  • Dorothea Becker
  • Laurent Bertoletti
  • Giuseppe Bettoni
  • Harald Binder
  • Regina Carels
  • Giuseppe Di Pasquale
  • Daniel Dürschmied
  • Iolanda Enea
  • Joachim Ficker
  • Sabine Genth-Zotz
  • Philippe Girard
  • Stanislav Gorbulev
  • Matthias Held
  • Lukas Hobohm
  • Menno V Huisman
  • Stavros V Konstantinides
  • Kai Kronfeld
  • Irene Marthe Lang
  • Mareike Lankeit
  • Walter Lehmacher
  • Concepcion Patricia Lopez Miguel
  • Nadine Martin
  • Guy Meyer
  • Roman Pareznik
  • Kurt Quitzau
  • Irinel Raluca Parepa
  • Purificacion Ramirez Martin
  • Marc Righini
  • Silviu Bogdan Todea
  • Adam Torbicki
  • Luca Valerio
  • Thomas Vanassche
  • Luminita Animarie Vida-Simiti
  • Anamaria Wolf-Pütz
DOI
10.1007/s00392-022-02138-4
eISSN
1861-0692
ISSN
1861-0684
Ausgabe der Veröffentlichung
10
Zeitschrift
Clinical Research in Cardiology
Sprache
en
Online publication date
2022
Paginierung
1372 - 1381
Datum der Veröffentlichung
2023
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/s00392-022-02138-4
Datum der Datenerfassung
2023
Titel
Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2
Ausgabe der Zeitschrift
112

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY
Autoren
  • Anna C Mavromanoli
  • Stefano Barco
  • Walter Ageno
  • Hélène Bouvaist
  • Marianne Brodmann
  • Claudio Cuccia
  • Francis Couturaud
  • Claudia Dellas
  • Konstantinos Dimopoulos
  • Daniel Duerschmied
  • Klaus Empen
  • Pompilio Faggiano
  • Emile Ferrari
  • Nazzareno Galiè
  • Marcello Galvani
  • Alexandre Ghuysen
  • George Giannakoulas
  • Menno V Huisman
  • David Jiménez
  • Matija Kozak
  • Irene M Lang
  • Nicolas Meneveau
  • Thomas Münzel
  • Massimiliano Palazzini
  • Antoniu Octavian Petris
  • Giancarlo Piovaccari
  • Aldo Salvi
  • Sebastian Schellong
  • Kai‑Helge Schmid
  • Franck Verschuren
  • Irene Schmidtmann
  • Gerrit Toenges
  • Frederikus A Klok
  • Stavros V Konstantinides
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-H
Resource version
Published version
DOI
10.1007/s00392-022-02138-4
File(s) embargoed
false
Open access
true
ISSN
1861-0692
Zeitschrift
Clinical research in cardiology
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
1372 - 1381
Datum der Veröffentlichung
2023
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/10110
Herausgeber
Springer Nature
Datum der Datenerfassung
2024
Datum, an dem der Datensatz öffentlich gemacht wurde
2024
Zugang
Public
Titel
Recovery of right ventricular function after intermediate-risk pulmonary embolism : results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2
Ausgabe der Zeitschrift
112

Files

recovery_of_right_ventricular-20240215105624265.pdf

Data source: OPENSCIENCE.UB

Tools