Can intermittent, time-restricted circadian fasting modulate cutaneous severity of dermatological disorders? Insights from a multicenter, observational, prospective study

Autoren

Nicola Luigi Bragazzi
Khaled Trabelsi
Sergio Garbarino
Achraf Ammar
Hamdi Chtourou
Alessia Pacifico
Piergiorgio Malagoli
Hristina Kocic
Rosalynn RZ Conic
Khalaf Kridin
Paolo Daniele Maria Pigatto
Giovanni Damiani

DOI

10.1111/dth.14912

eISSN

1529-8019

ISSN

1396-0296

Ausgabe der Veröffentlichung

3

Zeitschrift

Dermatologic Therapy

Sprache

en

Online publication date

2021

Datum der Veröffentlichung

2021

Status

Published

Herausgeber

Hindawi Limited

Herausgeber URL

http://dx.doi.org/10.1111/dth.14912

Datum der Datenerfassung

2023

Titel

Can intermittent,<scp>time‐restricted</scp>circadian fasting modulate cutaneous severity of dermatological disorders? Insights from a multicenter, observational, prospective study

Ausgabe der Zeitschrift

34

Data source: Crossref

Abstract

The impact of intermittent circadian fasting (ICF) on skin disorders is far to be plenty deciphered. However, the circadian rhythm seems to exert a modulation on dermatoses severity, drug-response, and drug-related side effects. We aimed to evaluate ICF effect in the daily management of dermatological diseases. In this multicenter, prospective observational study we enrolled patients willing to undergo the 2018 ICF (from May 16 to June 14). Dermatoses severity were evaluated at the beginning of ICF (T0) and at the end of ICF (T1) by two independent board-certified dermatologists. Seventy-two patients suffering from different dermatoses volunteered to take part into the study. They displayed a mean age of 40.38 ± 12.46 years (median 41.0 years), 25 subjects were males (34.7% of the entire sample). The median weight change was 0 kg. The overall ICF effect size was -0.58 ([95% CI -0.83 to -0.33], P < .0001, medium effect size). Since in the present investigation no weight loss occurred, we could speculate that the impact of fasting in terms of improvements in the clinical symptoms could be rather due to the perturbation of the human biological clock. Despite our data remain preliminary, a chronobiological approach should be incorporated in the dermatological armamentarium.

Addresses

Department of Health Sciences (DISSAL), Postgraduate School of Public Health, University of Genoa, Genoa, Italy.

Autoren

Nicola Luigi Bragazzi
Khaled Trabelsi
Sergio Garbarino
Achraf Ammar
Hamdi Chtourou
Alessia Pacifico
Piergiorgio Malagoli
Hristina Kocic
Rosalynn RZ Conic
Young Dermatologists Italian Network
Khalaf Kridin
Paolo Daniele Maria Pigatto
Giovanni Damiani

DOI

10.1111/dth.14912

eISSN

1529-8019

Externe Identifier

PubMed Identifier: 33629451

Open access

false

ISSN

1396-0296

Ausgabe der Veröffentlichung

3

Zeitschrift

Dermatologic therapy

Schlüsselwörter

Young Dermatologists Italian Network
Skin
Humans
Fasting
Prospective Studies
Circadian Rhythm
Adult
Middle Aged
Male

Sprache

eng

Medium

Print-Electronic

Online publication date

2021

Paginierung

e14912

Datum der Veröffentlichung

2021

Status

Published

Datum der Datenerfassung

2021

Titel

Can intermittent, time-restricted circadian fasting modulate cutaneous severity of dermatological disorders? Insights from a multicenter, observational, prospective study.

Sub types

Multicenter Study
Journal Article
Observational Study

Ausgabe der Zeitschrift

34

Data source: Europe PubMed Central

Abstract

The impact of intermittent circadian fasting (ICF) on skin disorders is far to be plenty deciphered. However, the circadian rhythm seems to exert a modulation on dermatoses severity, drug-response, and drug-related side effects. We aimed to evaluate ICF effect in the daily management of dermatological diseases. In this multicenter, prospective observational study we enrolled patients willing to undergo the 2018 ICF (from May 16 to June 14). Dermatoses severity were evaluated at the beginning of ICF (T0) and at the end of ICF (T1) by two independent board-certified dermatologists. Seventy-two patients suffering from different dermatoses volunteered to take part into the study. They displayed a mean age of 40.38 ± 12.46 years (median 41.0 years), 25 subjects were males (34.7% of the entire sample). The median weight change was 0 kg. The overall ICF effect size was -0.58 ([95% CI -0.83 to -0.33], P < .0001, medium effect size). Since in the present investigation no weight loss occurred, we could speculate that the impact of fasting in terms of improvements in the clinical symptoms could be rather due to the perturbation of the human biological clock. Despite our data remain preliminary, a chronobiological approach should be incorporated in the dermatological armamentarium.

Date of acceptance

2021

Autoren

Nicola Luigi Bragazzi
Khaled Trabelsi
Sergio Garbarino
Achraf Ammar
Hamdi Chtourou
Alessia Pacifico
Piergiorgio Malagoli
Hristina Kocic
Rosalynn RZ Conic
Young Dermatologists Italian Network
Khalaf Kridin
Paolo Daniele Maria Pigatto
Giovanni Damiani

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/33629451

DOI

10.1111/dth.14912

eISSN

1529-8019

Ausgabe der Veröffentlichung

3

Zeitschrift

Dermatol Ther

Schlüsselwörter

circadian rhythms and human biological clock
inflammatory dermatoses
intermittent fasting
time-restricted fasting
Adult
Circadian Rhythm
Fasting
Humans
Male
Middle Aged
Prospective Studies
Skin

Sprache

eng

Country

United States

Paginierung

e14912

Datum der Veröffentlichung

2021

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2021

Titel

Can intermittent, time-restricted circadian fasting modulate cutaneous severity of dermatological disorders? Insights from a multicenter, observational, prospective study.

Sub types

Journal Article
Multicenter Study
Observational Study

Ausgabe der Zeitschrift

34

Data source: PubMed

Can intermittent, time-restricted circadian fasting modulate cutaneous severity of dermatological disorders? Insights from a multicenter, observational, prospective study

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