Lignan contents of Schisandra chinensis (Turcz.) Baill. from different origins—A new model for evaluating the content of prominent components of Chinese herbs

Publication type:
Journal article
Metadata:
Autoren
  • Di He
  • Xinyi Pei
  • Bo Liu
  • Jiajing Li
  • Juane Dong
  • Thomas Efferth
  • Pengda Ma
DOI
10.1016/j.phymed.2024.155361
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
155361
Paginierung
155361 - 155361
Datum der Veröffentlichung
2024
Status
Accepted
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2024.155361
Datum der Datenerfassung
2024
Titel
Lignan contents of Schisandra chinensis (Turcz.) Baill. from different origins—A new model for evaluating the content of prominent components of Chinese herbs
Ausgabe der Zeitschrift
128

Data source: Crossref

Other metadata sources:
Abstract
<h4>Background</h4>As a traditional Chinese herbal medicine, Schisandra chinensis exhibits various effects such as liver protection, blood sugar regulation, blood lipid regulation, immune function regulation, antidepressant activity, etc. However, because of its intricate composition, diverse origins, and medicinal effects depending on complex compound groups, there are differences in the lignan composition of S. chinensis from different origins. Therefore, it is currently difficult to evaluate the quality of medicinal materials from plants of different origins using a single qualitative quality control index.<h4>Purpose</h4>This paper aims to investigate the potential relationship between the lignan components of S. chinensis from different origins and to establish stable assessment indices for determining the lignan content of S. chinensis from multiple perspectives.<h4>Methods</h4>In this study, we collected S. chinensis samples of seven major origins in China, and randomly sampled 6-9 batches of each origin for a total of 60 batches. The lignan content was determined by HPLC, and its distribution law of the ratio of each lignan component of S. chinensis to Schisandrol A content was analyzed. Combining network pharmacology and differential analysis between samples, the stable and effective substances used as quality markers were determined.<h4>Results</h4>There were some correlations among the lignan contents of S. chinensis, some correlations between schisandrin A and other lignans of S. chinensis could be determined. The ratio of each component to the indicator component schisandrol A was evenly distributed and reflected the lignan content of S. chinensis to some extent. Four substances (schisandrol A, schisandrol B, schisantherin A, and schisandrin C) were determined by network pharmacology combined with the analysis results of HCA, PCA and PLS-DA to further optimize the model. They displayed a strong connection with the core target, a large contribution rate to the principal components, and a stable content in each batch of samples, suggesting that these components may be the main active substances of S. chinensis lignans. Therefore, they could be used as main indicators evaluating the advantages and disadvantages of S. chinensis by examining the consistency of component proportions.<h4>Conclusion</h4>This method can intuitively evaluate the content of main lignans in S. chinensis. This quality assessment model is an exploration of the multi-component comprehensive evaluation system of S. chinensis, providing a new concept for the quality evaluation system of Chinese herbal medicines.
Addresses
  • College of Life Sciences, Northwest A&F University, Yangling 712100, China.
Autoren
  • Di He
  • Xinyi Pei
  • Bo Liu
  • Jiajing Li
  • Juane Dong
  • Thomas Efferth
  • Pengda Ma
DOI
10.1016/j.phymed.2024.155361
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 38552434
Funding acknowledgements
  • National Key Research and Development Program of China: 2021YFD1000203
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Schisandra
  • Cyclooctanes
  • Lignans
  • Dioxoles
  • Polycyclic Compounds
  • Drugs, Chinese Herbal
  • Chromatography, High Pressure Liquid
  • Principal Component Analysis
  • Quality Control
  • China
Sprache
eng
Medium
Print-Electronic
Online publication date
2024
Paginierung
155361
Datum der Veröffentlichung
2024
Status
Published online
Datum der Datenerfassung
2024
Titel
Lignan contents of Schisandra chinensis (Turcz.) Baill. from different origins-A new model for evaluating the content of prominent components of Chinese herbs.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
128

Data source: Europe PubMed Central

Abstract
BACKGROUND: As a traditional Chinese herbal medicine, Schisandra chinensis exhibits various effects such as liver protection, blood sugar regulation, blood lipid regulation, immune function regulation, antidepressant activity, etc. However, because of its intricate composition, diverse origins, and medicinal effects depending on complex compound groups, there are differences in the lignan composition of S. chinensis from different origins. Therefore, it is currently difficult to evaluate the quality of medicinal materials from plants of different origins using a single qualitative quality control index. PURPOSE: This paper aims to investigate the potential relationship between the lignan components of S. chinensis from different origins and to establish stable assessment indices for determining the lignan content of S. chinensis from multiple perspectives. METHODS: In this study, we collected S. chinensis samples of seven major origins in China, and randomly sampled 6-9 batches of each origin for a total of 60 batches. The lignan content was determined by HPLC, and its distribution law of the ratio of each lignan component of S. chinensis to Schisandrol A content was analyzed. Combining network pharmacology and differential analysis between samples, the stable and effective substances used as quality markers were determined. RESULTS: There were some correlations among the lignan contents of S. chinensis, some correlations between schisandrin A and other lignans of S. chinensis could be determined. The ratio of each component to the indicator component schisandrol A was evenly distributed and reflected the lignan content of S. chinensis to some extent. Four substances (schisandrol A, schisandrol B, schisantherin A, and schisandrin C) were determined by network pharmacology combined with the analysis results of HCA, PCA and PLS-DA to further optimize the model. They displayed a strong connection with the core target, a large contribution rate to the principal components, and a stable content in each batch of samples, suggesting that these components may be the main active substances of S. chinensis lignans. Therefore, they could be used as main indicators evaluating the advantages and disadvantages of S. chinensis by examining the consistency of component proportions. CONCLUSION: This method can intuitively evaluate the content of main lignans in S. chinensis. This quality assessment model is an exploration of the multi-component comprehensive evaluation system of S. chinensis, providing a new concept for the quality evaluation system of Chinese herbal medicines.
Date of acceptance
2024
Autoren
  • Di He
  • Xinyi Pei
  • Bo Liu
  • Jiajing Li
  • Juane Dong
  • Thomas Efferth
  • Pengda Ma
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/38552434
DOI
10.1016/j.phymed.2024.155361
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Component variability
  • Network pharmacology
  • Quality evaluation
  • Ratio consistency
  • Schisandra chinensis
  • Schisandra
  • Lignans
  • Drugs, Chinese Herbal
  • Chromatography, High Pressure Liquid
  • Cyclooctanes
  • China
  • Polycyclic Compounds
  • Dioxoles
  • Quality Control
  • Principal Component Analysis
Sprache
eng
Country
Germany
Paginierung
155361
PII
S0944-7113(24)00026-6
Datum der Veröffentlichung
2024
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2024
Titel
Lignan contents of Schisandra chinensis (Turcz.) Baill. from different origins-A new model for evaluating the content of prominent components of Chinese herbs.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
128

Data source: PubMed

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