FUScinating insights into motor neuron degeneration
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Dorothee Dormann
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000376184500002&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.15252/embj.201694397
- eISSN
- 1460-2075
- Externe Identifier
- Clarivate Analytics Document Solution ID: DM2NW
- PubMed Identifier: 27053723
- ISSN
- 0261-4189
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- EMBO JOURNAL
- Paginierung
- 1015 - 1017
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- FUScinating insights into motor neuron degeneration
- Sub types
- Editorial Material
- Ausgabe der Zeitschrift
- 35
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <jats:p>Point mutations in <jats:styled-content style="fixed-case">FUS</jats:styled-content> cause amyotrophic lateral sclerosis (<jats:styled-content style="fixed-case">ALS</jats:styled-content>), a devastating neurodegenerative disease—but do they do that by a loss of the protein's normal function, or by endowing it with novel toxic functions, or both? In this issue of <jats:italic>The <jats:styled-content style="fixed-case">EMBO</jats:styled-content> Journal</jats:italic>, Scekic‐Zahirovic <jats:italic>et al</jats:italic> (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#embj201694397-bib-0009" />) report that mutant <jats:styled-content style="fixed-case">FUS</jats:styled-content>, but not the complete loss of <jats:styled-content style="fixed-case">FUS</jats:styled-content>, triggers motor neuron degeneration in mice, arguing for a toxic gain‐of‐function mechanism.</jats:p>
- Autoren
- Dorothee Dormann
- DOI
- 10.15252/embj.201694397
- eISSN
- 1460-2075
- ISSN
- 0261-4189
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- The EMBO Journal
- Sprache
- en
- Online publication date
- 2016
- Paginierung
- 1015 - 1017
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.15252/embj.201694397
- Datum der Datenerfassung
- 2023
- Titel
- <scp>FUS</scp>cinating insights into motor neuron degeneration
- Ausgabe der Zeitschrift
- 35
Data source: Crossref
- Addresses
- BioMedical Center (BMC), Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany Munich Cluster for Systems Neurology (SyNergy), Munich, Germany Graduate School of Systemic Neurosciences (GSN), Planegg-Martinsried, Germany.
- Autoren
- Dorothee Dormann
- DOI
- 10.15252/embj.201694397
- eISSN
- 1460-2075
- Externe Identifier
- PubMed Identifier: 27053723
- PubMed Central ID: PMC4868949
- Open access
- false
- ISSN
- 0261-4189
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- The EMBO journal
- Schlüsselwörter
- Motor Neurons
- Humans
- Amyotrophic Lateral Sclerosis
- Motor Neuron Disease
- Nerve Degeneration
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2016
- Paginierung
- 1015 - 1017
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum der Datenerfassung
- 2016
- Titel
- FUScinating insights into motor neuron degeneration.
- Sub types
- article-commentary
- Comment
- Journal Article
- Ausgabe der Zeitschrift
- 35
Files
https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.201694397 https://europepmc.org/articles/PMC4868949?pdf=render
Data source: Europe PubMed Central
- Abstract
- Point mutations in FUS cause amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease—but do they do that by a loss of the protein's normal function, or by endowing it with novel toxic functions, or both? In this issue of The EMBO Journal, Scekic‐Zahirovic et al (2016) report that mutant FUS, but not the complete loss of FUS, triggers motor neuron degeneration in mice, arguing for a toxic gain‐of‐function mechanism.
- Autoren
- Dorothee Dormann
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/27053723
- DOI
- 10.15252/embj.201694397
- eISSN
- 1460-2075
- Externe Identifier
- PubMed Central ID: PMC4868949
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- EMBO J
- Schlüsselwörter
- Amyotrophic Lateral Sclerosis
- Humans
- Motor Neuron Disease
- Motor Neurons
- Nerve Degeneration
- Sprache
- eng
- Country
- England
- Paginierung
- 1015 - 1017
- PII
- embj.201694397
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2018
- Titel
- FUScinating insights into motor neuron degeneration.
- Sub types
- Journal Article
- Comment
- Ausgabe der Zeitschrift
- 35
Data source: PubMed
- Beziehungen:
- Property of