Zero-Field NMR Enhanced by Parahydrogen in Reversible Exchange

Publication type:
Journal article
Metadata:
Autoren
  • Thomas Theis
  • Micah P Ledbetter
  • Gwendal Kervern
  • John W Blanchard
  • Paul J Ganssle
  • Mark C Butler
  • Hyun D Shin
  • Dmitry Budker
  • Alexander Pines
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000301550800015&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1021/ja2112405
eISSN
1520-5126
Externe Identifier
  • Clarivate Analytics Document Solution ID: 909GL
  • PubMed Identifier: 22332806
ISSN
0002-7863
Ausgabe der Veröffentlichung
9
Zeitschrift
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Paginierung
3987 - 3990
Datum der Veröffentlichung
2012
Status
Published
Titel
Zero-Field NMR Enhanced by Parahydrogen in Reversible Exchange
Sub types
  • Article
Ausgabe der Zeitschrift
134

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Thomas Theis
  • Micah P Ledbetter
  • Gwendal Kervern
  • John W Blanchard
  • Paul J Ganssle
  • Mark C Butler
  • Hyun D Shin
  • Dmitry Budker
  • Alexander Pines
DOI
10.1021/ja2112405
eISSN
1520-5126
ISSN
0002-7863
Ausgabe der Veröffentlichung
9
Zeitschrift
Journal of the American Chemical Society
Sprache
en
Online publication date
2012
Paginierung
3987 - 3990
Datum der Veröffentlichung
2012
Status
Published
Herausgeber
American Chemical Society (ACS)
Herausgeber URL
http://dx.doi.org/10.1021/ja2112405
Datum der Datenerfassung
2023
Titel
Zero-Field NMR Enhanced by Parahydrogen in Reversible Exchange
Ausgabe der Zeitschrift
134

Data source: Crossref

Abstract
We have recently demonstrated that sensitive and chemically specific NMR spectra can be recorded in the absence of a magnetic field using hydrogenative parahydrogen induced polarization (PHIP) (1-3) and detection with an optical atomic magnetometer. Here, we show that non-hydrogenative parahydrogen-induced polarization (4-6) (NH-PHIP) can also dramatically enhance the sensitivity of zero-field NMR. We demonstrate the detection of pyridine, at concentrations as low as 6 mM in a sample volume of 250 μL, with sufficient sensitivity to resolve all identifying spectral features, as supported by numerical simulations. Because the NH-PHIP mechanism is nonreactive, operates in situ, and eliminates the need for a prepolarizing magnet, its combination with optical atomic magnetometry will greatly broaden the analytical capabilities of zero-field and low-field NMR.
Addresses
  • Materials Science Division, Lawrence Berkeley National Laboratory, Berkeley California 94720, USA.
Autoren
  • Thomas Theis
  • Micah P Ledbetter
  • Gwendal Kervern
  • John W Blanchard
  • Paul J Ganssle
  • Mark C Butler
  • Hyun D Shin
  • Dmitry Budker
  • Alexander Pines
DOI
10.1021/ja2112405
eISSN
1520-5126
Externe Identifier
  • PubMed Identifier: 22332806
Open access
false
ISSN
0002-7863
Ausgabe der Veröffentlichung
9
Zeitschrift
Journal of the American Chemical Society
Schlüsselwörter
  • Hydrogen
  • Pyridines
  • Magnetic Resonance Spectroscopy
Sprache
eng
Medium
Print-Electronic
Online publication date
2012
Paginierung
3987 - 3990
Datum der Veröffentlichung
2012
Status
Published
Datum der Datenerfassung
2012
Titel
Zero-field NMR enhanced by parahydrogen in reversible exchange.
Sub types
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Journal Article
Ausgabe der Zeitschrift
134

Data source: Europe PubMed Central

Abstract
We have recently demonstrated that sensitive and chemically specific NMR spectra can be recorded in the absence of a magnetic field using hydrogenative parahydrogen induced polarization (PHIP) (1-3) and detection with an optical atomic magnetometer. Here, we show that non-hydrogenative parahydrogen-induced polarization (4-6) (NH-PHIP) can also dramatically enhance the sensitivity of zero-field NMR. We demonstrate the detection of pyridine, at concentrations as low as 6 mM in a sample volume of 250 μL, with sufficient sensitivity to resolve all identifying spectral features, as supported by numerical simulations. Because the NH-PHIP mechanism is nonreactive, operates in situ, and eliminates the need for a prepolarizing magnet, its combination with optical atomic magnetometry will greatly broaden the analytical capabilities of zero-field and low-field NMR.
Autoren
  • Thomas Theis
  • Micah P Ledbetter
  • Gwendal Kervern
  • John W Blanchard
  • Paul J Ganssle
  • Mark C Butler
  • Hyun D Shin
  • Dmitry Budker
  • Alexander Pines
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/22332806
DOI
10.1021/ja2112405
eISSN
1520-5126
Ausgabe der Veröffentlichung
9
Zeitschrift
J Am Chem Soc
Schlüsselwörter
  • Hydrogen
  • Magnetic Resonance Spectroscopy
  • Pyridines
Sprache
eng
Country
United States
Paginierung
3987 - 3990
Datum der Veröffentlichung
2012
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2012
Titel
Zero-field NMR enhanced by parahydrogen in reversible exchange.
Sub types
  • Journal Article
  • Research Support, U.S. Gov't, Non-P.H.S.
Ausgabe der Zeitschrift
134

Data source: PubMed

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