Relaxivity of Gadolinium Complexes Detected by Atomic Magnetometry

Publication type:
Journal article
Metadata:
Autoren
  • David J Michalak
  • Shoujun Xu
  • Thomas J Lowery
  • CW Crawford
  • Micah Ledbetter
  • Louis-S Bouchard
  • David E Wemmer
  • Dmitry Budker
  • Alexander Pines
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000293256800033&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/mrm.22811
Externe Identifier
  • Clarivate Analytics Document Solution ID: 799AV
  • PubMed Identifier: 21433067
ISSN
0740-3194
Ausgabe der Veröffentlichung
2
Zeitschrift
MAGNETIC RESONANCE IN MEDICINE
Schlüsselwörter
  • atomic magnetometry
  • relaxivity
  • gadolinium
Paginierung
605 - 608
Datum der Veröffentlichung
2011
Status
Published
Titel
Relaxivity of Gadolinium Complexes Detected by Atomic Magnetometry
Sub types
  • Article
Ausgabe der Zeitschrift
66

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:title>Abstract</jats:title><jats:p>Laser atomic magnetometry is a portable and low‐cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote‐detection geometry to measure the relaxivity of aqueous gadolinium‐diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth's magnetic field (40 μT). The measured relaxivity of 9.7 ± 2.0 s<jats:sup>−1</jats:sup> mM<jats:sup>−1</jats:sup> is consistent with field‐cycling experiments measured at slightly higher magnetic fields, but no cryogens or strong and homogeneous magnetic field were required for this experiment. The field‐independent sensitivity of 80 fT Hz<jats:sup>–1/2</jats:sup> allowed an in vitro detection limit of ∼ 10 μM Gd(DTPA) to be measured in aqueous buffer solution. The low detection limit and enhanced relaxivity of Gd‐containing complexes at Earth's field motivate continued development of atomic magnetometry toward medical applications. Magn Reson Med 66:603–606, 2011. © 2011 Wiley‐Liss, Inc.</jats:p>
Autoren
  • David J Michalak
  • Shoujun Xu
  • Thomas J Lowery
  • CW Crawford
  • Micah Ledbetter
  • Louis‐S Bouchard
  • David E Wemmer
  • Dmitry Budker
  • Alexander Pines
DOI
10.1002/mrm.22811
eISSN
1522-2594
ISSN
0740-3194
Ausgabe der Veröffentlichung
2
Zeitschrift
Magnetic Resonance in Medicine
Sprache
en
Online publication date
2011
Paginierung
603 - 606
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/mrm.22811
Datum der Datenerfassung
2023
Titel
Relaxivity of gadolinium complexes detected by atomic magnetometry
Ausgabe der Zeitschrift
66

Data source: Crossref

Abstract
Laser atomic magnetometry is a portable and low-cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote-detection geometry to measure the relaxivity of aqueous gadolinium-diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth's magnetic field (40 μT). The measured relaxivity of 9.7±2.0 s(-1) mM(-1) is consistent with field-cycling experiments measured at slightly higher magnetic fields, but no cryogens or strong and homogeneous magnetic field were required for this experiment. The field-independent sensitivity of 80 fT Hz(-1/2) allowed an in vitro detection limit of ∼10 μM Gd(DTPA) to be measured in aqueous buffer solution. The low detection limit and enhanced relaxivity of Gd-containing complexes at Earth's field motivate continued development of atomic magnetometry toward medical applications.
Addresses
  • Materials Sciences Division, Lawrence Berkeley National Laboratory, Department of Chemistry, University of California, Berkeley, California, USA.
Autoren
  • David J Michalak
  • Shoujun Xu
  • Thomas J Lowery
  • CW Crawford
  • Micah Ledbetter
  • Louis-S Bouchard
  • David E Wemmer
  • Dmitry Budker
  • Alexander Pines
DOI
10.1002/mrm.22811
eISSN
1522-2594
Externe Identifier
  • PubMed Identifier: 21433067
Funding acknowledgements
  • Nuclear Sciences Division of the U.S. Department of Energy:
  • U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering: DE-AC02-05CH11231
  • ONR MURI grant:
Open access
false
ISSN
0740-3194
Ausgabe der Veröffentlichung
2
Zeitschrift
Magnetic resonance in medicine
Schlüsselwörter
  • Gadolinium
  • Contrast Media
  • Magnetic Resonance Spectroscopy
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Equipment Design
  • Equipment Failure Analysis
  • Drug Evaluation, Preclinical
  • Magnetometry
Sprache
eng
Medium
Print-Electronic
Online publication date
2011
Paginierung
605 - 608
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2011
Titel
Relaxivity of gadolinium complexes detected by atomic magnetometry.
Sub types
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Journal Article
Ausgabe der Zeitschrift
66

Data source: Europe PubMed Central

Abstract
Laser atomic magnetometry is a portable and low-cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote-detection geometry to measure the relaxivity of aqueous gadolinium-diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth's magnetic field (40 μT). The measured relaxivity of 9.7±2.0 s(-1) mM(-1) is consistent with field-cycling experiments measured at slightly higher magnetic fields, but no cryogens or strong and homogeneous magnetic field were required for this experiment. The field-independent sensitivity of 80 fT Hz(-1/2) allowed an in vitro detection limit of ∼10 μM Gd(DTPA) to be measured in aqueous buffer solution. The low detection limit and enhanced relaxivity of Gd-containing complexes at Earth's field motivate continued development of atomic magnetometry toward medical applications.
Date of acceptance
2010
Autoren
  • David J Michalak
  • Shoujun Xu
  • Thomas J Lowery
  • CW Crawford
  • Micah Ledbetter
  • Louis-S Bouchard
  • David E Wemmer
  • Dmitry Budker
  • Alexander Pines
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21433067
DOI
10.1002/mrm.22811
eISSN
1522-2594
Ausgabe der Veröffentlichung
2
Zeitschrift
Magn Reson Med
Schlüsselwörter
  • Contrast Media
  • Drug Evaluation, Preclinical
  • Equipment Design
  • Equipment Failure Analysis
  • Gadolinium
  • Magnetic Resonance Spectroscopy
  • Magnetometry
  • Reproducibility of Results
  • Sensitivity and Specificity
Sprache
eng
Country
United States
Paginierung
605 - 608
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2012
Titel
Relaxivity of gadolinium complexes detected by atomic magnetometry.
Sub types
  • Journal Article
  • Research Support, U.S. Gov't, Non-P.H.S.
Ausgabe der Zeitschrift
66

Data source: PubMed

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